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Top 5 Foods that Boost Nitric Oxide Naturally

Medically reviewed by 
 
Top 5 Foods that Boost Nitric Oxide Naturally

Cardiovascular disease (CVD) is the leading cause of death globally. Over 11% of the United States population has diabetes. Alzheimer's disease is a neurodegenerative condition that was the third leading cause of death for Americans in 2019. Despite appearing unrelated, these conditions may all be linked to nitric oxide insufficiency.

Nitric oxide plays multifaceted roles in cardiovascular health, metabolic regulation, and neuronal function. Its deficiency has been implicated in endothelial dysfunction, impaired insulin sensitivity, and diminished cerebral blood flow. Optimizing nitric oxide through dietary interventions represents a promising avenue toward mitigating the development and progression of chronic diseases, offering hope for improved public health outcomes.

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Understanding Nitric Oxide and Its Health Benefits

Nitric oxide (NO) is a gaseous molecule produced naturally within the body. It is most notorious for its role as a vasodilator, meaning it relaxes the muscles of blood vessels to allow them to widen. But it also transmits messages within the cardiovascular, immune, endocrine, and nervous systems. Its actions have widespread effects on human health, and nitric oxide supplementation has been studied to treat high blood pressure, erectile dysfunction, physical endurance, insulin resistance, neurodegeneration, poor wound healing, and inflammation. (12

Two main pathways are responsible for NO production in the body.

The nitric oxide synthase (NOS)-dependent pathway involves the conversion of the amino acid L-arginine to NO by the enzyme NOS. There are three NOS isoforms:

  1. Endothelial Nitric Oxide Synthase (eNOS): Found predominantly in endothelial cells lining blood vessels, eNOS produces NO to regulate vascular tone, blood pressure, and blood flow. It also plays a role in maintaining the integrity of the endothelium, preventing platelet aggregation, and inhibiting smooth muscle cell proliferation. (36
  2. Neuronal Nitric Oxide Synthase (nNOS): Primarily located in nerve cells, nNOS generates NO for neurotransmission, synaptic plasticity, and neuroprotection. nNOS regulates functions like learning and memory. (16
  3. Inducible Nitric Oxide Synthase (iNOS): iNOS produces NO as part of the immune response. While iNOS-derived NO can help combat pathogens and regulate inflammation, excessive or prolonged production may contribute to tissue damage in conditions like sepsis, cancer, and pain. (9

The NOS-independent pathway involves bacteria in our mouth and stomach. Oral bacteria take dietary nitrate and turn it into nitrite. The food bolus enters the stomach after swallowing, where some of the nitrite is converted into NO in the acidic environment.

Top 5 Foods to Boost Nitric Oxide Naturally

Symptoms of low nitric oxide levels include high blood pressure, high blood sugar, erectile dysfunction, muscle soreness, and slow wound healing. Consider incorporating the following foods into your diet to boost nitric oxide levels. 

#1 Beets: 

Beets have gained attention for their potential to boost NO synthesis due to their high nitrate content. Dietary nitrates act as the precursory molecule for NO synthesis via the NOS-independent pathway. Once NO has been synthesized in the stomach, it can enter the bloodstream and exert its various physiological effects.

Research suggests that dietary nitrate supplementation, such as with beetroot or beetroot juice, can elevate circulating levels of NO metabolites and positively impact cardiovascular and exercise-related outcomes.

#2 Garlic: 

Garlic, particularly aged garlic extract, can potentially reduce cardiovascular risk by lowering blood pressure, total cholesterol, and markers of systemic inflammation. 

These benefits are attributed to garlic's primary active constituent, allicin, which is broken down into various sulfur-containing compounds. One mechanism by which allicin is believed to confer cardioprotective effects is its ability to activate eNOS activity, which induces vasodilation and blood pressure reductions. 

#3 Leafy Greens: 

Approximately 80% of dietary nitrates are derived from vegetable consumption. Nitrate-rich green leafy vegetables include spinach, lettuce, kale, arugula, chard, and cabbage.

In an observational study, researchers examined data collected over 23 years from more than 50,000 people in Denmark who had participated in the Danish Diet, Cancer, and Health Study. They found that people who ate one cup of raw (or one-half cup of cooked) nitrate-rich vegetables daily had about 2.5 mmHg lower systolic blood pressure and a 12-26% lower risk of cardiovascular disease. (33

#4 Citrus Fruits: 

Reactive oxygen species (ROS) are major culprits of NO breakdown. Vitamin C, or ascorbic acid, is an antioxidant. Antioxidants scavenge and neutralize free radicals so that they can not degrade NO. (14

Additionally, tetrahydrobiopterin (BH4) is a cofactor required for the proper functioning of eNOS. Vitamin C helps regenerate BH4 to prevent deficiency, which is involved in NOS dysfunction. (17, 38

Several studies have demonstrated the potential of vitamin C supplementation or increased intake of vitamin C-rich foods, such as citrus fruits, in reducing blood pressure and vascular oxidative stress.

#5 Nuts and Seeds: 

Nuts and seeds are high in arginine, the amino acid that acts as the building block for NO in the NOS-dependent synthesis pathway. 

In a cross-sectional study involving over 2,700 men and women, researchers found that a higher intake of dietary arginine was associated with higher NO levels in the blood. Research has also shown that regularly eating nuts, particularly pistachios and sesame seeds, is correlated to lower systolic and diastolic blood pressure readings. 

Incorporating Nitric Oxide-Boosting Foods into Your Diet

Incorporating nitric oxide-boosting foods into your daily eating habits can be delicious and beneficial for your health. By following a plant-based, anti-inflammatory diet, you will inherently be adding NO-boosting foods to your diet. Here are some meal ideas to help you integrate these foods into your diet:

Smoothies

Blend banana, spinach, Greek yogurt, beet juice, and a splash of orange or grapefruit juice together for a nutrient-packed smoothie rich in vitamin C and nitrates. Add a tablespoon of flaxseeds or nut butter for an extra boost of fiber and arginine. 

Salads

Salads are a great side dish to add to any meal to meet your dietary requirements for leafy greens. One example is tossing fresh spinach and arugula together and topping with walnuts and sliced strawberries. Dress the salad with a simple vinaigrette dressing. 

Hummus

Hummus is a dip made from mashed chickpeas blended with tahini (sesame seed paste), lemon juice, garlic, and olive oil. Hummus is easy to make at home by combining all the ingredients in a food processor. You can even add cooked beets to the recipe to enhance its NO-boosting properties. Serve with your favorite crackers or veggie sticks. 

Other Lifestyle Factors Affecting Nitric Oxide Levels

In addition to mindful dietary choices, other lifestyle habits can help boost NO levels naturally.  

Exercise: 

During exercise, increased blood flow and oxygen delivery to tissues stimulate the release of eNOS. This elevated eNOS activity leads to higher levels of NO, promoting vasodilation, improving blood flow, and enhancing oxygen delivery to working muscles. (28

Exercise also increases antioxidant activity, inhibiting the breakdown of NO caused by free radicals. 

Engaging in a home-based exercise program of 30 minutes of aerobic exercise three days per week for four weeks can increase NO levels. 

Sunlight Exposure: 

When the skin is exposed to ultraviolet (UV) rays from sunlight, it triggers the conversion of stored nitrate and nitrite compounds in the skin into NO. UVA rays can upregulate iNOS in the skin to release enough NO to create a vasodilatory effect and reduce blood pressure. (19

Avoidance of Nitric Oxide Inhibitors: 

Just as certain compounds can upregulate NO production, some factors can diminish NO levels. Avoiding NO inhibitors will increase NO's bioavailability.

Smoking

Smoking tobacco inhibits NO production by inhibiting NOS enzyme expression. Tobacco smoke also contains ROS, which can further deplete NO levels. (7, 8)

For many reasons (including reducing the risk of heart disease, lung disease, and cancer), it is highly encouraged to quit smoking and avoid secondhand smoke. The CDC provides many resources for those who need support in quitting. 

Mouthwash

While antiseptic mouthwashes can kill oral bacteria responsible for causing dental and gum disease, they also kill the beneficial bacteria responsible for converting nitrates to nitrites for up to 12 hours after use. To maintain adequate NO production via the NOS-independent pathway, it is encouraged to limit your use of mouthwash.

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Key Takeaways

  • Nitric oxide is a signaling molecule produced naturally in the body that plays important roles in blood flow, endothelial function, neurotransmission, and immune responses.
  • Health conditions related to insufficient NO levels may include high blood pressure, cardiovascular disease, and neurodegenerative diseases.
  • Mindful dietary and lifestyle choices can support NO levels to prevent diseases related to NO deficiency and maintain optimal wellness.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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  1. Aljuraiban, G. S., Gibson, R., Chan, D. S., et al. (2023). The role of diet in the prevention of hypertension and management of blood pressure: An umbrella review of meta-analyses of interventional and observational studies. Advances in Nutrition, 15(1). https://doi.org/10.1016/j.advnut.2023.09.011
  2. Baik, J. S., Min, J. H., Ju, S. M., et al. (2022). Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomized Controlled Trial. Nutrients, 14(24), 5238. https://doi.org/10.3390/nu14245238
  3. Basaqr, R., Skleres, M., Jayswal, R., et al. (2020). The effect of dietary nitrate and vitamin C on endothelial function, oxidative stress and blood lipids in untreated hypercholesterolemic subjects: A randomized double-blind crossover study. Clinical Nutrition, 40(4). https://doi.org/10.1016/j.clnu.2020.10.012
  4. Blake, K. (2023, May 22). Anti Inflammatory Diet 101: What to Eat and Avoid Plus Specialty Labs To Monitor Results. Rupa Health. https://www.rupahealth.com/post/anti-inflammatory-diet
  5. Blake, K. (2023, November 14). Integrative Strategies for Neurodegenerative Disease Management. Rupa Health. https://www.rupahealth.com/post/integrative-strategies-for-neurodegenerative-disease-management
  6. Bosnir, D. B. J., Bevardi, M., Boskovic, A. G., et al. (2017). NITRATE IN LEAFY GREEN VEGETABLES AND ESTIMATED INTAKE. African Journal of Traditional, Complementary and Alternative Medicines, 14(3), 31–41. https://doi.org/10.21010/ajtcam.v14i3.4
  7. Caliri, A. W., Tommasi, S., & Besaratinia, A. (2021). Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation Research/Reviews in Mutation Research, 787, 108365. https://doi.org/10.1016/j.mrrev.2021.108365
  8. Chambers, D. C., Tunnicliffe, W. S., & Ayres, J. G. (1998). Acute inhalation of cigarette smoke increases lower respiratory tract nitric oxide concentrations. Thorax, 53(8), 677–679. https://doi.org/10.1136/thx.53.8.677
  9. Cinelli, M. A., Do, H. T., Miley, G. P., et al. (2019). Inducible nitric oxide synthase: Regulation, structure, and inhibition. Medicinal Research Reviews, 40(1), 158–189. https://doi.org/10.1002/med.21599
  10. Cloyd, J. (2023, April 27). Unlocking the Health Benefits of Nitric Oxide: How This Molecule Supports Cardiovascular Health, Exercise Performance, and More. Rupa Health. https://www.rupahealth.com/post/nitric-oxide
  11. Cloyd, J. (2023, November 2). The Top 5 Therapeutic Uses of Garlic: From the Kitchen to the Medicine Cabinet. Rupa Health. https://www.rupahealth.com/post/the-top-5-therapeutic-uses-of-garlic-from-the-kitchen-to-the-medicine-cabinet
  12. DeCesaris, L. (2023, September 14). Unraveling the Power of Nitric Oxide: Functions, Benefits, and Top Nitric Oxide Supplements for Optimal Health. Rupa Health. https://www.rupahealth.com/post/unraveling-the-power-of-nitric-oxide-functions-benefits-and-top-nitric-oxide-supplements-for-optimal-health
  13. Domínguez, R., Cuenca, E., Maté-Muñoz, J., et al. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, 9(1), 43.
  14. Figueroa-Méndez, R., & Rivas-Arancibia, S. (2015). Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain. Frontiers in Physiology, 6. https://doi.org/10.3389/fphys.2015.00397
  15. Fletcher, J. (2018, October 4). Which foods are high in arginine? Medical News Today. https://www.medicalnewstoday.com/articles/323259#high-arginine-foods
  16. Förstermann, U., & Sessa, W. C. (2012). Nitric oxide synthases: regulation and function. European Heart Journal, 33(7), 829–837, 837a837d. https://doi.org/10.1093/eurheartj/ehr304
  17. Gonçalves, D. A., Jasiulionis, M. G., & Henriques, F. (2021). The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin. International Journal of Molecular Sciences, 22(17), 9546–9546. https://doi.org/10.3390/ijms22179546
  18. He, S., Wei, Y., Fan, X., et al. (2011). A clinical study to assess the 12-hour antimicrobial effects of cetylpyridinium chloride mouthwashes on supragingival plaque bacteria. The Journal of Clinical Dentistry, 22(6), 195–199. https://pubmed.ncbi.nlm.nih.gov/22403975/
  19. Holliman, G., Lowe, D., Cohen, H., et al. (2017). Ultraviolet Radiation-Induced Production of Nitric Oxide: A multi-cell and multi-donor analysis. Scientific Reports, 7, 11105. https://doi.org/10.1038/s41598-017-11567-5
  20. Hord, N. G., Tang, Y., & Bryan, N. S. (2009). Food sources of nitrates and nitrites: the physiologic context for potential health benefits. The American Journal of Clinical Nutrition, 90(1), 1–10. https://doi.org/10.3945/ajcn.2008.27131
  21. How to quit smoking . (2019, August 2). Centers for Disease Control and Prevention. https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/index.html
  22. Ji, L. L. (2002). Exercise-induced Modulation of Antioxidant Defense. Annals of the New York Academy of Sciences, 959(1), 82–92. https://doi.org/10.1111/j.1749-6632.2002.tb02085.x
  23. Kelm, M. (1999). Nitric oxide metabolism and breakdown. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1411(2-3), 273–289. https://doi.org/10.1016/s0005-2728(99)00020-1
  24. Khakham, C. (2023, August 17). A Root Cause Medicine Approach: A Comprehensive Guide On How To Test For Low Nitric Oxide Levels. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-approach-a-comprehensive-guide-on-how-to-test-for-low-nitric-oxide-levels
  25. Khosravi-Boroujeni, H., Nikbakht, E., Natanelov, E., et al. (2017). Can sesame consumption improve blood pressure? A systematic review and meta-analysis of controlled trials. Journal of the Science of Food and Agriculture, 97(10), 3087–3094. https://doi.org/10.1002/jsfa.8361
  26. Lewis, T. V., Dart, A. M., Chin-Dusting, J. P. F., et al. (1999). Exercise Training Increases Basal Nitric Oxide Production From the Forearm in Hypercholesterolemic Patients. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(11), 2782–2787. https://doi.org/10.1161/01.atv.19.11.2782
  27. Lopez, E. O., & Jan, A. (2023, August 22). Cardiovascular Disease. National Library of Medicine; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK535419/
  28. Magerman, R. (2024, March 19). Natural Ways to Increase Nitric Oxide Levels. Rupa Health. https://www.rupahealth.com/post/natural-ways-to-increase-nitric-oxide-levels
  29. Mirmiran, P., Bahadoran, Z., Ghasemi, A., et al. (2016). The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study. Nutrients, 8(5). https://doi.org/10.3390/nu8050311
  30. Mohammadifard, N., Salehi-Abargouei, A., Salas-Salvadó, J., et al. (2015). The effect of tree nut, peanut, and soy nut consumption on blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials. The American Journal of Clinical Nutrition, 101(5), 966–982. https://doi.org/10.3945/ajcn.114.091595
  31. National diabetes statistics report. (2023, November 29). Centers for Disease Control and Prevention. https://www.cdc.gov/diabetes/data/statistics-report/index.html
  32. Onakpoya, I., O'Sullivan, J., Heneghan, C., et al. (2015). The effect of grapefruits (Citrus paradisi) on body weight and cardiovascular risk factors: A systematic review and meta-analysis of randomized clinical trials. Critical Reviews in Food Science and Nutrition, 57(3), 602–612. https://doi.org/10.1080/10408398.2014.901292
  33. One cup of leafy green vegetables a day lowers risk of heart disease. Nutrition & Health Innovation Research Institute. Retrieved April 9, 2024, from https://nhiri.ecu.edu.au/research/one-cup-of-leafy-green-vegetables-a-day-lowers-risk-of-heart-disease/
  34. Varshney, R., & Budoff, M. J. (2016, February 1). Garlic and Heart Disease. The Journal of Nutrition. https://pubmed.ncbi.nlm.nih.gov/26764327/
  35. Sweetnich, J. (2023, May 9). Vitamin C 101: Understanding Testing, RDAs, and The Benefits of Supplementation. Rupa Health. https://www.rupahealth.com/post/vitamin-c-101
  36. Tran, N., Garcia, T., Aniqa, M., et al. (2022). Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States. American Journal of Biomedical Science & Research, 15(2), 153–177. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774925/
  37. Weinberg, J. L. (2024, January 2). Impact of Plant-Based Diets on Chronic Inflammation Reduction. Rupa Health. https://www.rupahealth.com/post/impact-of-plant-based-diets-on-chronic-inflammation-reduction
  38. Yan, J., Tie, G., & Messina, L. M. (2012). Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidant Stress and Increase Nitric Oxide That Increases Blood Flow Recovery after Hindlimb Ischemia in the Rat. Molecular Medicine, 18(8), 1221–1230. https://doi.org/10.2119/molmed.2011.00103.revised
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