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Reference Guide
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Genova Diagnostics
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Metabolomix+

Metabolomix+

By 
Genova Diagnostics
Metabolomix+
Genova Diagnostics
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About the Test

The Metabolomix+ combines a variety of tests to analyze key nutritional biomarkers, including organic acids, amino acids, and oxidative stress markers. This test cannot be ordered for patients under two years of age.

What is the Metabolomix+?

Metabolomix+ is a comprehensive nutritional assessment tool. It integrates multiple nutritional tests to provide an extensive evaluation of an individual's nutritional status.

This test is geared towards identifying specific nutritional deficiencies or imbalances. It is used to help clinicians customize nutritional therapies to meet the precise needs of their patients.

The primary method for sample collection is a first morning void (FMV) urine collection. Optional add-ons include a bloodspot finger stick and a buccal swab, enhancing the test's comprehensiveness.

Notably, the entire test can be conducted at home, which adds to its patient-friendly aspect.

What Does the Metabolomix+ Test For?

Nutritional Biomarkers: The test focuses on evaluating the functional need for vital nutrients, including antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids.

Broad Health Assessment: By testing for these nutrients, the Metabolomix+ offers insights into various aspects of health and wellness, allowing for a broad and in-depth analysis.

Personalized Nutritional Therapy: The results from this test are instrumental in tailoring dietary recommendations and supplements to address each individual's unique nutritional requirements effectively.

Unique Features

Comprehensive Analysis: Metabolomix+ stands out due to its amalgamation of various methodologies and biomarkers, providing a unique and thorough nutritional assessment.

Ease of Interpretation: The test results are presented in a format that is easy to interpret, enabling clinicians to make informed decisions regarding nutritional interventions.

Comparison with NutrEval: Similar to the NutrEval test, but with the added convenience of at-home collection.

Clinical Significance

Tailored Therapies: Insights from Metabolomix+ enable healthcare providers to create personalized and effective nutritional therapy plans.

Broad Utility: This test is a valuable tool in the arsenal of healthcare providers for accurately assessing and addressing the nutritional needs of their patients.

In summary, Metabolomix+ is a comprehensive, patient-friendly nutritional assessment tool that provides crucial insights for personalized nutritional therapies, emphasizing its importance in modern healthcare.

Ideal Candidates for Metabolomix+ Lab Testing

The Metabolomix+ lab test, a comprehensive functional nutritional assessment, plays a crucial role in identifying nutritional imbalances that might be underlying or exacerbating various health conditions. Its broad application makes it an invaluable tool in personalized healthcare. 

While it is's beneficial for a diverse range of patients, there are specific groups who stand to gain the most from this testing. 

Patients with Mood Disorders: Individuals suffering from conditions like depression and anxiety may find this test particularly insightful. Nutritional factors can significantly influence mood disorders, and identifying specific imbalances can guide effective treatment strategies.

Individuals with Mitochondrial Dysfunction: Mitochondrial health is crucial for energy production and overall metabolic function. Patients with mitochondrial dysfunction can benefit from understanding their unique nutritional needs to support mitochondrial health which is significant in aging and many chronic diseases including certain neurodegenerative, cardiovascular, and autoimmune conditions.

People Experiencing Chronic Fatigue: Persistent fatigue, often a complex symptom with multiple causes, can be linked to nutritional deficiencies. This test can help pinpoint nutritional changes that might alleviate fatigue symptoms.

Those Under Chronic Stress: Chronic stress affects the body's nutritional balance in various ways. The Metabolomix+ test can reveal how stress is impacting an individual's nutritional status, paving the way for targeted interventions.

Patients with Inflammation-Related Conditions: Inflammation can be both a cause and a symptom of nutritional imbalances. Understanding these relationships can be crucial in managing inflammatory conditions.

Individuals with Specific Diseases: Diseases such as cardiovascular issues, neurocognitive decline, diabetes, cancer, and depression and anorexia can be  associated with abnormal levels of certain biomarkers. This test provides insights into the nutritional aspects that may be contributing to these conditions.

It is important to note that this test is not suitable for patients under 2 years old due to the unique metabolic and nutritional needs of very young children.

Overview of the Metabolomix+ Profile Report

The Metabolomix+ Profile is a comprehensive report that categorizes results into several key metabolic areas. This profile helps in understanding various aspects of an individual’s health by analyzing a range of metabolic markers. The report is structured into several sections, each providing specific insights:

Personalized Results Overview and Nutrient Need Overview

  • Personalized Results Overview: This section provides a summary of the individual's metabolic profile.
  • Nutrient Need Overview: Recommendations are provided for essential nutrients like antioxidants, B-vitamins, minerals, essential fatty acids, gastrointestinal support, and amino acids. Results are color coded to facilitate identification of nutrient requirements.

Functional Imbalance Scores

  • Assessment Areas: This includes evaluations of methylation, toxic exposure, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress, using a numerical score to identify support needsInterpretation-At-A-Glance Pages
  • Nutritional Education: These pages offer educational support, highlighting the function and sources of each nutrient, causes and complications of deficiencies.

Organic Acids (Urine)

  • Malabsorption and Dysbiosis Markers: Metabolites indicating gastrointestinal microbiome health.
  • Cellular Energy & Mitochondrial Metabolites: Biomarkers related to carbohydrate and fatty acid metabolism, and the Kreb’s cycle.
  • Neurotransmitter Metabolites: Byproducts of epinephrine, norepinephrine, serotonin, and dopamine.
  • Vitamin Markers: Analytes used to assess functional levels of vitamin cofactors.
  • Toxin & Detoxification Markers: Indicators of toxic metabolites and the body’s detoxification capacity.
  • Oxalate Markers: Related to kidney stone formation, oxidative stress, and metabolic dysfunction.

Amino Acids (Urine)

  • Essential Amino Acids: Must be obtained from diet.
  • Nonessential Amino Acids: Synthesized by the body.
  • Intermediary Metabolites: Byproducts of amino acid metabolism.
  • B Vitamin Markers: Involved in reactions requiring B vitamins.
  • Urea Cycle Markers: Associated with nitrogen detoxification.
  • Glycine/Serine Metabolites: Involved in methylation pathways.
  • Dietary Peptide Markers: Indicative of protein breakdown and meat intake.

Oxidative Stress Markers (Urine)

  • Markers Included: Lipid peroxides and 8-OHdG, indicating oxidative damage.

Additional Components of the Metabolomix+ Profile

Add-on Essential and Metabolic Fatty Acids Markers (Bloodspot)

  • Omega 3 Fatty Acids: Crucial for brain function, cardiovascular health, and anti-inflammatory function.
  • Omega 6 Fatty Acids: Balancing inflammation.
  • Omega 9 Fatty Acids: Important for brain growth, nerve cell myelin, and reducing inflammation.
  • Saturated Fatty Acids: Involved in lipoprotein metabolism and adipose tissue inflammation.
  • Monounsaturated Fats: Include omega 7 fats and trans fats.
  • Delta-6 Desaturase Activity: Assesses enzyme efficiency in metabolizing omega 6 and omega 3 faty acids
  • Cardiovascular Risk: Specific ratios and the Omega 3 Index.

Add-on Comprehensive Urine Element Profile

  • Assessment: Analyzes 20 toxic and 15 mineral elements, and includes creatinine concentration for kidney function

Add-on SNPs (Buccal Swab)

  • Included SNPs: MTHFR, COMT, TNF-a, and APOE. which can provide information on methylation, inflammation, and cholesterol regulation.

About the Test

The Metabolomix+ combines a variety of tests to analyze key nutritional biomarkers, including organic acids, amino acids, and oxidative stress markers. This test cannot be ordered for patients under two years of age.

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Biomarkers

Dihydroxyphenylpropionic Acid
Dihydroxyphenylpropionic Acid
a-Amino-N-Butyric Acid
a-Amino-N-Butyric Acid
2-Hydroxyisobutyric Acid
2-Hydroxyisobutyric Acid
Citramalic Acid
Citramalic Acid
4-Hydroxyphenylacetic Acid
4-Hydroxyphenylacetic Acid
5-Hydroxyindoleacetic Acid
5-Hydroxyindoleacetic Acid
3-Hydroxybutyric Acid
3-Hydroxybutyric Acid
2-Hydroxybutyric Acid
2-Hydroxybutyric Acid
b-Alanine
b-Alanine
Pyroglutamic Acid
Pyroglutamic Acid
Gamma-aminobutyric acid
Gamma-aminobutyric acid
3-OH-3-Methylglutaric Acid
3-OH-3-Methylglutaric Acid
Methylmalonic Acid
Methylmalonic Acid
Vanillylmandelic Acid
Vanillylmandelic Acid
Anserine
Anserine
Beta-Aminoisobutyric Acid
Beta-Aminoisobutyric Acid
Homovanillic Acid
Homovanillic Acid
Kynurenic Acid
Kynurenic Acid
2-Hydroxyphenylacetic Acid
2-Hydroxyphenylacetic Acid
Xanthurenic Acid
Xanthurenic Acid
a-Aminoadipic Acid
a-Aminoadipic Acid
Glutaric Acid
Glutaric Acid
Tartaric Acid
Tartaric Acid
Hippuric Acid
Hippuric Acid
Carnosine
Carnosine
3-Indoleacetic Acid
3-Indoleacetic Acid
Valine
Valine
Threonine
Threonine
Taurine
Taurine
Quinolinic Acid
Quinolinic Acid
3-Hydroxyisovaleric Acid
3-Hydroxyisovaleric Acid
alpha-Ketophenylacetic Acid
alpha-Ketophenylacetic Acid
Isovalerylglycine
Isovalerylglycine
Kynurenic/Quinolinic Ratio
Kynurenic/Quinolinic Ratio
1-Methylhistidine
1-Methylhistidine
Phosphoserine
Phosphoserine
Phosphoethanolamine
Phosphoethanolamine
Phenylalanine
Phenylalanine
Phenylacetic Acid
Phenylacetic Acid
Cystine
Cystine
Oxalic Acid
Oxalic Acid
Tyrosine
Tyrosine
Orotic Acid
Orotic Acid
Ornithine
Ornithine
3-Hydroxyproprionic Acid
3-Hydroxyproprionic Acid
Proline
Proline
Methionine
Methionine
Malic Acid
Malic Acid
Lysine
Lysine
Lipid Peroxides
Lipid Peroxides
Lactic Acid
Lactic Acid
Isocitric Acid
Isocitric Acid
Pyruvic Acid
Pyruvic Acid
Histidine
Histidine
Glycolic Acid
Glycolic Acid
Glycine
Glycine
Glyceric Acid
Glyceric Acid
Succinic Acid
Succinic Acid
Suberic Acid
Suberic Acid
Glutamic Acid
Glutamic Acid
Sarcosine
Sarcosine
Formiminoglutamic Acid
Formiminoglutamic Acid
Ethanolamine
Ethanolamine
Tryptophan
Tryptophan
D-Arabinitol
D-Arabinitol
Cystathionine
Cystathionine
Creatinine
Creatinine
Citrulline
Citrulline
Citric Acid
Citric Acid
Urea
Urea
Cis-Aconitic Acid
Cis-Aconitic Acid
Benzoic/Hippuric Acids Ratio
Benzoic/Hippuric Acids Ratio
Benzoic Acid
Benzoic Acid
a-Keto-b-Methylvaleric Acid
a-Keto-b-Methylvaleric Acid
a-Ketoadipic Acid
a-Ketoadipic Acid
a-Ketoisovaleric Acid
a-Ketoisovaleric Acid
a-Ketoglutaric Acid
a-Ketoglutaric Acid
Fasting Glucose
Fasting Glucose
a-Ketoisocaproic Acid
a-Ketoisocaproic Acid
Isoleucine
Isoleucine
8-Hydroxy-2-deoxyguanosine
8-Hydroxy-2-deoxyguanosine
Cysteine
Cysteine
Asparagine
Asparagine
Glutamine
Glutamine
Serine
Serine
Aspartic Acid
Aspartic Acid
Alanine
Alanine
Adipic Acid
Adipic Acid
Arginine
Arginine
Leucine
Leucine
4-Hydroxyphenylpyruvic Acid
4-Hydroxyphenylpyruvic Acid
3-Methylhistidine
3-Methylhistidine
3-Methyl-4-OH-phenylglycol
3-Methyl-4-OH-phenylglycol
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Lab Test Information
Price
$
319
.00
 $
319.00
Sign up to View
Sample Type
Urine
Category
Shipping Time
5 - 10 days
FedEx
Turnaround Time
21 days
Test Preparation Starts
Up to 4 days before collection
Number of Collection Days
1 day
Methods Used For Processing
HPLC, LC-MS/MS, Colorimetric Assay, Hexokinase/G6PDH Method, TBARS Assay, GC-MS, Alkaline Picrate
Lab Certifications
CLIA Certified
CAP Accredited
ISO 15189
COLA Accredited
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