The Advanced IBA profile is the only test designed to directly measure leaky gut.
Clinicians often use food sensitivity testing or even stool testing to indirectly assess the health of the gut lining, but these are direct markers of a leaky gut. The IBA measures the three areas most connected to gut permeability, Zonulin, DAO, and LPS.
Plasma Zonulin is a well-documented marker of permeability, as it is the trigger that causes tight junctions to open, creating a leaky gut. However, there are other ways we become leaky. You can also wear the gut lining down, creating atrophy, as in the overuse of NSAIDs.
Low diamine oxidase shows the thickness of the gut lining and also lets the clinician know if the patient’s ability to degrade histamine is compromised. A ratio of Histamine to DAO is also provided to elucidate whether or not the patient has the correct balance between histamine and the enzyme degrading it, DAO.
Lipopolysaccharides (LPS) are endotoxins produced by gram-negative bacteria. LPS antibodies go up when the patient is fighting LPS at levels that break down tight junctions and result in permeability. This test measures all the significant ways in which the gut becomes leaky.
Precision Point Diagnostics' Advanced Intestinal Barrier Assessment (AIBA) provides a comprehensive view of patients' intestinal barrier function to help identify intestinal permeability ("leaky gut") and inflammation.
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