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Are Your Patients on Antihypertensive Drugs?: How Root Cause Medicine Can Complement Their Treatment

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Are Your Patients on Antihypertensive Drugs?: How Root Cause Medicine Can Complement Their Treatment

High blood pressure, also referred to as hypertension, is a prevalent health condition that impacts nearly half of American adults. Defined as systolic blood pressure greater than 130 mm Hg and diastolic blood pressure greater than 80 mm Hg, over 60 million adults in the US self-report taking antihypertensive medications that may be effective but do not address the underlying cause of the condition.

As a leading risk factor for cardiovascular diseases (CVD) like heart attack, stroke, and heart failure, patients with hypertension need more than medications. The growing number of people’s lives influenced by this chronic disease highlights the need for comprehensive hypertension management. Recently, there has been an increasing adoption of using personalized treatment protocols, such as those in root cause medicine, to complement traditional antihypertensive therapy to improve long-term patient outcomes. 

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Overview of Antihypertensive Therapy

Antihypertensive therapy is considered the mainstay of traditional elevated blood pressure management. This category of prescription drugs consists of several classes, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers, and diuretics. These medications reduce blood pressure through mechanisms such as relaxing blood vessels, decreasing overall blood volume (hypervolemia), and lowering cardiac workload.

Consistent administration, also known as adherence, is vital to decrease the chance of adverse cardiovascular events and maximize systolic and diastolic blood pressure improvements. Despite their effectiveness, pharmacotherapy targeting blood pressure can also have unwanted side effects, including fatigue, dizziness, and electrolyte imbalances. This imbalance of effectiveness, paired with side effects, calls for a more patient-centric approach to hypertension care. 

Root Cause Medicine Principles in Hypertension Care

Root cause medicine is an individualized approach to patient care that addresses the root causes of disease rather than treating symptoms. From a patient-centric perspective, root cause medicine considers a person’s overall health and well-being, including genetic factors and environmental exposures. Specifically for hypertension management, practitioners can look beyond prescriptions alone to use tailored methods and lifestyle modifications–such as lab testing, nutrition, stress management, movement, and dietary supplements–to help patients lower their blood pressure.

Integrating Root Cause Medicine with Antihypertensive Therapy

Implementing the use of root cause medicine into a comprehensive care regimen for patients with hypertension may improve patient outcomes. Root cause medicine can help mitigate the side effects of antihypertensive drugs, enhancing patient adherence and quality of life. Research has shown the benefits of combining root cause (functional) medicine with antihypertensive therapy for improving blood pressure control.

A recent review found that a comprehensive lifestyle intervention, including dietary changes, physical activity, and stress reduction techniques, led to significant blood pressure reductions among hypertension participants. Another study showed that a combination of dietary changes and stress management techniques as first-line therapy to prevent and control hypertension in adulthood was as effective as medication in lowering blood pressure. Practitioners can address the root causes of hypertension and provide comprehensive care for the hypertensive patient population. While root cause medicine can complement traditional treatments for hypertension, it is important for patients to work with an interdisciplinary care team.

Dietary Considerations and Supplements

For patients with hypertension, nutrition plays a pivotal role in its progression. In both traditional and root cause medicine treatment protocols, there are cardioprotective diets–all emphasizing common principles of increasing dietary fiber, lowering sodium intake, optimizing saturated fat intake, and increasing nutrient-dense foods. Dietary planning is highly individualized, so practitioners should consider a patient’s needs, goals, and potential interactions with their medication regimen.

The Dietary Approaches to Stop Hypertension, also known as the DASH Diet, was initially developed to manage hypertension. This dietary model prioritizes fruits, vegetables, whole grains, and lean proteins while limiting sodium, unhealthy saturated fats, and refined sugars. Studies have shown that the DASH Diet can reduce blood pressure as well as the overall risk of death from CVD. A variation of the DASH Diet is called the MIND Diet, combining principles of the Mediterranean and DASH Diets. This nutritional recommendation emphasizes vegetables, nuts, healthy oils, fish, and lean meat. 

Incorporating specific nutrients into the diet through nutrition or dietary supplements, such as omega-3 fatty acids and certain vitamins and minerals, can also support blood pressure reduction. Omega-3 fatty acids, found in fish oil supplements or fatty fish like salmon and mackerel, have been shown to reduce blood pressure levels. Magnesium-rich foods like spinach, almonds, and avocado can help relax blood vessels and lower blood pressure. Dietary sources of potassium, such as bananas, oranges, and potatoes, can counteract the effects of sodium and help regulate blood pressure.

Stress Management and Its Impact on Hypertension

Stress management plays a crucial role in hypertension management, as stress can contribute to elevated blood pressure levels. Chronic stress activates the body's "fight or flight" response, leading to increased heart rate and blood pressure. Over time, this can put a strain on the cardiovascular system and contribute to the development of hypertension.

Root cause medicine emphasizes the importance of stress management in optimizing blood pressure. Stress reduction techniques such as mindfulness meditation, yoga, and biofeedback can help lower blood pressure by reducing stress levels. Research has shown that these techniques can improve cardiovascular health and reduce the risk of heart disease and stroke. 

Mindfulness meditation is an effective stress management technique that involves focusing on the present moment and cultivating a non-judgmental cognizance of thoughts and feelings. Studies have shown that mindfulness meditation can decrease blood pressure and improve cardiovascular health, among other benefits including reduced anxiety, depression, and perceived stress.

Physical Activity as a Pillar of Hypertension Management 

Regular physical activity is essential for managing hypertension, as it can lower blood pressure and improve cardiovascular health. Practitioners often recommend a combination of aerobic exercise, strength training, and flexibility exercises customized to the individual patient's needs and abilities. Combining physical activity with medication can have synergistic effects, further enhancing blood pressure control. Another study found that combining aerobic exercise with medication was more effective in lowering blood pressure than medication alone.

Exercise helps lower blood pressure by improving blood vessel function, reducing inflammation, and promoting weight loss. It also helps reduce stress levels and improve mood, contributing to overall well-being. In addition, studies have shown that increasing exercise as a part of a multidimensional integrative medicine protocol promoted weight loss and reduced 10-year cardiovascular risk.

Monitoring and Adjusting Treatment 

Practitioners use specialized lab testing to determine individualized treatment regimens for patients with cardiovascular disease. Tests such as those that evaluate lipids, inflammatory markers, oxidative stress markers, genetics, and more can provide valuable insights into a person’s risk factors for hypertension and help formulate treatment plans accordingly.

Regular monitoring and follow-up are essential for assessing the effectiveness of combined treatment approaches. Using regular lab testing to monitor specific cardiovascular biomarkers can facilitate the adjustment of treatment plans based on patient progress, potentially leading to antihypertensive dosing changes and/or the addition of integrative therapies. By closely monitoring patients, healthcare providers can ensure that patient-centered treatment goals are met and adjust interventions as required.

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Key Takeaways 

Hypertension is a chronic disease state that currently impacts millions of patients in the United States. As incidence continues to increase, the paradigm of hypertension management needs to be refreshed to a patient-centric approach.

While antihypertensive medications are a part of the treatment protocol, integrating complementary modalities such as diet, physical activity, supplements, stress management, and specialized lab testing, root cause medicine can help patients to achieve optimal blood pressure levels and reduce their risk of long-term cardiovascular complications.

Working in a collaborative interdisciplinary team, including a root cause or functional medicine practitioner, patients can use these multi-faceted, personalized medicine strategies to improve their quality of life.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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  1. Mayo Clinic. (2024). High Blood Pressure (Hypertension) . Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20373410 
  2. Centers for Disease Control and Prevention. (2021). Facts about Hypertension. CDC. https://www.cdc.gov/bloodpressure/facts.htm
  3. Samanic, C. M., Barbour, K. E., Liu, Y., Fang, J., Lu, H., Schieb, L., & Greenlund, K. J. (2020). Prevalence of Self-Reported Hypertension and Antihypertensive Medication Use Among Adults — United States, 2017. MMWR. Morbidity and Mortality Weekly Report, 69(14), 393–398. https://doi.org/10.15585/mmwr.mm6914a1 
  4. Mayo Clinic. (2022). Heart attack - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/heart-attack/symptoms-causes/syc-20373106 
  5. American Stroke Association. (2023). About Stroke. American Stroke Association. https://www.stroke.org/en/about-stroke 
  6. Dumitru, I. (2023). Heart Failure: Practice Essentials, Background, Pathophysiology. EMedicine. https://emedicine.medscape.com/article/163062-overview 
  7. Yoshimura, H. (2023). Using Functional Medicine As Personalized Medicine. Rupa Health. https://www.rupahealth.com/post/using-functional-medicine-as-personalized-medicine 
  8. ‌Davey, J. A. (2023). Functional Medicine Vs. Conventional Medicine: Key Differences. Rupa Health. https://www.rupahealth.com/post/functional-medicine-vs-conventional-medicine-key-differences 
  9. Cleveland Clinic. (2021). Angiotensin-Converting Enzyme (ACE) Inhibitors. Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/21934-ace-inhibitors 
  10. Cleveland Clinic. (2022). Angiotensin II Receptor Blockers (ARBs): Uses and Side Effects. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/23327-angiotensin-ii-receptor-blockers
  11. Mayo Clinic. (2023). What you should know about beta blockers. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/beta-blockers/art-20044522
  12. Mayo Clinic. (2023). How do calcium channel blockers work? Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/calcium-channel-blockers/art-20047605
  13. Mayo Clinic. (2021). What to know about diuretics (water pills). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/diuretics/art-20048129 
  14. Cleveland Clinic. (2022). Hypervolemia Symptoms, Causes & Treatment. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/22962-hypervolemia 
  15. Hamrahian, S. M., Maarouf, O. H., & Fülöp, T. (2022). A Critical Review of Medication Adherence in Hypertension: Barriers and Facilitators Clinicians Should Consider. Patient Preference and Adherence, Volume 16(16), 2749–2757. https://doi.org/10.2147/ppa.s368784 
  16. Canoy, D., Copland, E., Nazarzadeh, M., Ramakrishnan, R., Pinho-Gomes, A.-C., Salam, A., Dwyer, J. P., Farzadfar, F., Sundström, J., Woodward, M., Davis, B. R., & Rahimi, K. (2022). Antihypertensive drug effects on long-term blood pressure: an individual-level data meta-analysis of randomised clinical trials. Heart, 108(16), heartjnl-2021-320171. https://doi.org/10.1136/heartjnl-2021-320171 
  17. Medline Plus. (2016). High blood pressure medicines: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/007484.htm 
  18. Greenan, S. (2021). What is Functional Medicine? How Do I Find A Functional Medicine Practitioner? Rupa Health. https://www.rupahealth.com/post/what-is-functional-medicine 
  19. Neibling, K. (2023). Complementary and Integrative Medicine Treatments for Hypertension and Cardiovascular Disease. Rupa Health. https://www.rupahealth.com/post/complementary-and-integrative-medicine-treatments-for-hypertension-and-cardiovascular-disease 
  20. Cloyd, J. (2023). A Functional Medicine Hypertension Protocol. Rupa Health. https://www.rupahealth.com/post/functional-medicine-hypertension-protocol 
  21. Ojangba, T., Boamah, S., Miao, Y., Guo, X., Fen, Y., Agboyibor, C., Yuan, J., & Dong, W. (2023). Comprehensive effects of lifestyle reform, adherence, and related factors on hypertension control: A review. Journal of clinical hypertension, 25(6), 509–520. https://doi.org/10.1111/jch.14653 
  22. Charchar, F. J., Prestes, P. R., Mills, C., Ching, S. M., Neupane, D., Marques, F. Z., Sharman, J. E., Vogt, L., Burrell, L. M., Korostovtseva, L., Zec, M., Patil, M., Schultz, M. G., Wallen, M. P., Renna, N. F., Islam, S. M. S., Hiremath, S., Gyeltshen, T., Chia, Y. C., Gupta, A., Tomaszewski, M. (2024). Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension. Journal of hypertension, 42(1), 23–49. https://doi.org/10.1097/HJH.0000000000003563
  23. Christie, J. (2022). 95% of American’s Aren’t Getting Enough Fiber: How Many Grams Should We Be Consuming Per Day? Rupa Health. https://www.rupahealth.com/post/95-of-americans-arent-getting-enough-fiber-how-many-grams-of-fiber-should-we-be-consuming-per-day 
  24. Grillo, A., Salvi, L., Coruzzi, P., Salvi, P., & Parati, G. (2019). Sodium Intake and Hypertension. Nutrients, 11(9), 1970. https://doi.org/10.3390/nu11091970 
  25. Cloyd, J. (2022). 9 Health Benefits of the DASH Diet. Www.rupahealth.com. https://www.rupahealth.com/post/9-health-benefits-of-the-dash-diet
  26. Szczepańska, E., Białek-Dratwa, A., Janota, B., & Kowalski, O. (2022). Dietary Therapy in Prevention of Cardiovascular Disease (CVD)—Tradition or Modernity? A Review of the Latest Approaches to Nutrition in CVD. Nutrients, 14(13), 2649. https://doi.org/10.3390/nu14132649 
  27. Manchanda S. C. (2014). Yoga--a promising technique to control cardiovascular disease. Indian heart journal, 66(5), 487–489. https://doi.org/10.1016/j.ihj.2014.08.013 
  28. Moravec, C. S., & McKee, M. G. (2011). Biofeedback in the treatment of heart disease. Cleveland Clinic journal of medicine, 78 Suppl 1, S20–S23. https://doi.org/10.3949/ccjm.78.s1.03 
  29. Teeter, L. A. (2023). Mental Health Benefits of Yoga and Meditation. Rupa Health. https://www.rupahealth.com/post/mental-health-benefits-of-yoga-and-meditation 
  30. Parswani, M. J., Sharma, M. P., & Iyengar, S. (2013). Mindfulness-based stress reduction program in coronary heart disease: A randomized control trial. International journal of yoga, 6(2), 111–117. https://doi.org/10.4103/0973-6131.113405 
  31. Warburton, D. E. R., Nicol, C. W., & Bredin, S. S. D. (2006). Health Benefits of Physical activity: the Evidence. Canadian Medical Association Journal, 174(6), 801–809. https://doi.org/10.1503/cmaj.051351 
  32. Diet Review: MIND Diet. (2022). Harvard T.H. Chan School of Public Health - The Nutrition Source. 
  33. https://www.hsph.harvard.edu/nutritionsource/healthy-weight/diet-reviews/mind-diet/ 
  34. Khakham, C. (2023). Integrative Cardiology: Lifestyle and Natural Approaches to Heart Health. Rupa Health. https://www.rupahealth.com/post/integrative-cardiology-lifestyle-and-natural-approaches-to-heart-health 
  35. DePorto, T. (2023). Omega 3’s: The Superfood Nutrient You Need To Know About. Rupa Health. https://www.rupahealth.com/post/omega-3s-the-superfood-nutrient-you-need-to-know-about 
  36. Mori T. A. (2010). Omega-3 fatty acids and blood pressure. Cellular and molecular biology (Noisy-le-Grand, France), 56(1), 83–92.
  37. Han, M., Zhang, Y., Fang, J., Sun, M., Liu, Q., Ma, Z., Hu, D., Gong, X., Liu, Y., Jin, L., Liu, Z., & Ma, Y. (2024). Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia. Hypertension research : official journal of the Japanese Society of Hypertension, 47(2), 331–341. https://doi.org/10.1038/s41440-023-01439-z 
  38. McLean, R. M., & Wang, N. X. (2021). Potassium. Advances in food and nutrition research, 96, 89–121. https://doi.org/10.1016/bs.afnr.2021.02.013
  39. Cloyd, J. (2023). A Functional Medicine Approach to Stress Management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management 
  40. Pescatello, L. S., Wu, Y., Gao, S., Livingston, J., Sheppard, B. B., & Chen, M.-H. (2021). Do the combined blood pressure effects of exercise and antihypertensive medications add up to the sum of their parts? A systematic meta-review. BMJ Open Sport & Exercise Medicine, 7(1), e000895. https://doi.org/10.1136/bmjsem-2020-000895 
  41. Saco‐Ledo, G., Valenzuela, P. L., Ruiz‐Hurtado, G., Ruilope, L. M., & Lucia, A. (2020). Exercise Reduces Ambulatory Blood Pressure in Patients With Hypertension: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association, 9(24). https://doi.org/10.1161/jaha.120.018487 
  42. Pinckard, K., Baskin, K. K., & Stanford, K. I. (2019). Effects of Exercise to Improve Cardiovascular Health. Frontiers in cardiovascular medicine, 6, 69. https://doi.org/10.3389/fcvm.2019.00069
  43. Harvard Health Publishing. (2019). More evidence that exercise can boost mood - Harvard Health. Harvard Health; Harvard Health. https://www.health.harvard.edu/mind-and-mood/more-evidence-that-exercise-can-boost-mood 
  44. Edelman, D., Oddone, E. Z., Liebowitz, R. S., Yancy, W. S., Olsen, M. K., Jeffreys, A. S., Moon, S. D., Harris, A. C., Smith, L. L., Quillian-Wolever, R. E., & Gaudet, T. W. (2006). A multidimensional integrative medicine intervention to improve cardiovascular risk. Journal of General Internal Medicine, 21(7), 728–734. https://doi.org/10.1111/j.1525-1497.2006.00495.x 
  45. Khakham, C. (2023). Understanding Your Risk of Cardiovascular Disease With Functional Medicine Labs. Rupa Health. https://www.rupahealth.com/post/understanding-your-risk-of-cardiovascular-disease-with-functional-medicine-labs 
  46. Khakham, C. (2023). Top Labs To Run Bi-Annually On Your High Blood Pressure Patients. Rupa Health. https://www.rupahealth.com/post/top-labs-to-run-bi-annually-on-your-high-blood-pressure-patients 
  47. Canzanello, V. J., Jensen, P. L., & Hunder, I. (2001). Rapid adjustment of antihypertensive drugs produces a durable improvement in blood pressure. American journal of hypertension, 14(4 Pt 1), 345–350. https://doi.org/10.1016/s0895-7061(00)01273-5 
  48. Jaeger, B. C., Chen, L., Foti, K., Hardy, S. T., Bress, A. P., Kane, S. P., Huang, L., Herrick, J. S., Derington, C. G., Bharat Poudel, Christenson, A., Colantonio, L. D., & Muntner, P. (2023). Hypertension Statistics for US Adults: An Open-Source Web Application for Analysis and Visualization of National Health and Nutrition Examination Survey Data. Hypertension, 80(6), 1311–1320. https://doi.org/10.1161/hypertensionaha.123.20900
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