Dr. Colleen Cutcliffe, Cofounder and CEO of Pendulum Therapeutics, is leading a dedicated team in their pursuit of groundbreaking and transformative solutions for gut health-related ailments, showcasing a remarkable passion for improving people's lives through revolutionary, safe, and effective microbiome interventions.
In today's episode with Dr. Colleen Cutcliffe, you’ll hear us take a deep dive on:
1. The evolution of antibiotics and how their broad spectrum also harms the gut microbiome, potentially causing long-term issues like food sensitivities, chronic illnesses, and conditions beyond the digestive system, such as obesity and neurological disorders.
2. The recent discovery of the keystone probiotic strain Akkermansia, which resides in the gut lining, and its crucial role in preventing gut lining deterioration.
3. Akkermansia’s benefits, including producing proteins that stimulate GLP-1, a hormone involved in regulating insulin and glucose response to prevent high glucose spikes and promote weight loss.
4. How neurons in the gut communicate with the brain, influencing cravings and other functions, and recent studies indicate that neurological conditions like Parkinson's and Alzheimer's may manifest in gut neurons before brain cells.
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