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Utilizing Functional Medicine Labs In Practice To Help Individualize Nutrition Options for Type 2 Diabetics

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Utilizing Functional Medicine Labs In Practice To Help Individualize Nutrition Options for Type 2 Diabetics

In today's fast-paced world, where processed and convenience foods dominate grocery shelves and our plates, the prevalence of type 2 diabetes has reached alarming levels. Type 2 diabetes affects 33-35 million Americans and is the seventh leading cause of death in the United States. This chronic condition, characterized by high blood sugar levels, poses significant health risks and requires careful management to prevent serious health complications.

While medication can play a crucial role in disease management, nutrition is a cornerstone in effective prevention against and management of type 2 diabetes. A well-balanced and personalized diet can effectively control blood sugar, improve insulin sensitivity, and enhance the quality of life and overall well-being. This article will shed light on the importance of nutrition in type 2 diabetes management, providing evidence-based guidance on making informed dietary choices in relation to blood sugar management.  


Understanding Type 2 Diabetes

Type 2 diabetes results when cells in muscle, fat, and the liver become resistant to insulin and, eventually, the pancreas cannot make enough insulin to keep blood sugar levels within a healthy range. Genetic, lifestyle, and environmental factors are key contributors to the disease's development and progression. Ethnicity, family history, genetics, advancing age, obesity, physical inactivity, and unhealthy diet can impair healthy glucose metabolism and contribute to insulin resistance and an increased risk of type 2 diabetes. (1-3)

While some risk factors, like genetics and age, are beyond our control, adopting a heart-healthy lifestyle and diet can significantly reduce the risk of developing type 2 diabetes and manage the condition effectively. The foods we eat directly affect blood sugar levels, insulin sensitivity, and satiety signals. In addition, food choices affect body weight, blood pressure, and cholesterol levels, which, in conjunction with diabetes, influence the risk of cardiovascular disease and health outcomes. (4)

Realizing these concepts, nutritional therapy must be a first-line intervention in treating diabetes. The primary goal of nutrition therapy is to achieve and maintain stable and normal blood sugar levels with proper dietary choices, including balanced carbohydrate intake, macro- and micronutrient distribution, portion control, and timing of meals. A healthy diet also helps patients to meet other health-related goals and provides the essential nutrients to support cardiovascular and overall health, manage blood pressure and cholesterol levels, maintain a healthy weight, and reduce the risk of complications associated with type 2 diabetes. (5)  

Macronutrient Considerations for Type 2 Diabetes

Considering the macronutrient composition of the diet is crucial for blood sugar control, weight management, and overall health. Here are some key macronutrient considerations specific to treating type 2 diabetes:


Carbohydrates directly affect blood sugar levels as they break down into glucose during digestion. Glucose is absorbed into the bloodstream, and the pancreas secretes insulin to signal cells to uptake sugar in the blood for energy metabolism or storage. (6)

Choosing the right types and amounts of carbohydrates is essential to regulate blood sugar and insulin. Simple carbohydrates have simple chemical structures composed of only one or two sugars. They are easily and quickly used for energy and can lead to rapid spikes in blood sugar and insulin secretion. In contrast, complex carbohydrates have more complex chemical structures of three or more sugars. In addition, they also contain fiber, vitamins, and minerals and are digested by the body more slowly. This leads to a steadier rise in blood sugar levels. (6)

To better explain how carbohydrates affect blood sugar, the concepts of glycemic index (GI) and glycemic load (GL) were developed. The GI is a system that ranks carbohydrates on a scale from 0 to 100 based on how quickly and to what extent they raise blood sugar levels after eating. Foods with a low GI (55 or below) result in a gradual and steady rise in blood sugar, while foods with a high GI (70 and above) lead to more significant and rapid increases in blood sugar levels. Low-glycemic foods have been shown to control type 2 diabetes, improve weight loss, and may offer anti-inflammatory benefits. (6)

GL is a measure that considers the GI of a food and the amount of carbohydrates it contains per serving. GL can provide a more accurate assessment of the overall impact of food on blood sugar because it considers both a food’s GI and the amount of carbohydrates it contains per serving. A GL of 20 or more is high, 11 to 19 is medium, and 10 or under is low. A large meta-analysis concluded that people who consumed lower GL diets were at a lower risk of developing type 2 diabetes than those eating higher GL diets. (6)


Adequate protein intake is important in managing type 2 diabetes for various reasons. First, protein is known to have a higher satiety value than carbohydrates and fats, so including protein-rich foods in meals and snacks increases feelings of fullness and reduces overall calorie intake. This can be beneficial for controlling appetite, reducing cravings, preventing overeating, and managing weight. Protein is also essential for building muscle tissue. Studies have shown that increased muscle mass increases skeletal muscle glucose uptake and improves insulin sensitivity.

Patients with type 2 diabetes should opt for lean protein sources, which provide essential amino acids without contributing to excessive saturated fat intake. Examples include skinless poultry, fish, lean cuts of red meat, eggs, tofu, and legumes. Generally, dietary protein intake should be aimed at a target level of 0.8 g/kg body weight daily. To simplify matters, the American Diabetes Association (ADA) developed the Diabetes Plate Method to plan portions without any need for calculations. Per this method, the ADA recommends that one-quarter of a 9-inch plate be filled with protein foods per meal. (7)


Research suggests that reducing carbohydrate intake while increasing unsaturated fats in a healthy diet improves insulin sensitivity. Unsaturated fats, further subclassified as monounsaturated or polyunsaturated, contain double bonds in their chemical structure. Unsaturated fats are considered our "healthy" fats because they improve lipid profiles and hold anti-inflammatory properties. Sources of unsaturated fats include fish, olives, nuts, seeds, and avocados. (8)

In contrast, evidence supports that excess intake of saturated and trans fats worsens lipid profiles, systemic inflammation, and cardiovascular health outcomes. This is why the American Heart Association (AHA) recommends reducing the intake of saturated fats to less than 6% of total daily calories and eliminating trans fats from the diet (8).

Micronutrient Considerations for Type 2 Diabetes

Summarized below are some key micronutrient considerations for individuals with type 2 diabetes.


Fiber offers several benefits for blood sugar control and weight management. Soluble fiber forms a gel-like substance in the digestive tract, which slows the digestion and absorption of carbohydrates. This results in a slower and more gradual release of glucose in the bloodstream, preventing blood sugar spikes. Insoluble fiber allows cells to utilize glucose from the bloodstream more effectively by enhancing insulin sensitivity. Foods high in fiber, including whole grains, legumes, whole fruits, and vegetables, provide a sustained release of energy to help maintain stable blood sugar levels throughout the day and prevent energy crashes and food cravings. (9)

Adding high-fiber foods to the diet helps achieve and maintain a healthy weight. Fiber adds bulk to meals. Because of this, many fiber-rich foods are relatively low in calories, help create a feeling of fullness with fewer calories consumed, and keep you satisfied for more extended periods. (10)

The AHA recommends a daily intake of 25-30 grams of fiber. To meet this goal, focus on incorporating more whole foods into the diet, such as fruits, vegetables, whole grains, beans, nuts, and seeds. (10)

Vitamins and Minerals

Vitamins and minerals play essential roles in converting glucose into energy, regulating blood sugar levels, and improving insulin sensitivity. B vitamins are essential cofactors in various enzymatic reactions that use glucose to convert it into usable energy. Magnesium is involved in over 300 enzymatic reactions in the body, including those related to glucose metabolism, and it plays a role in insulin secretion, insulin action, and glucose transport (11). Chromium enhances the action of insulin, facilitating the uptake of glucose into cells and the regulation of blood sugar levels. Adequate vitamin D status is linked to reduced occurrence of insulin resistance because it is an important vitamin in reducing inflammation.

Functional Medicine Labs That Can Help Individualize Nutrition Options for Type 2 Diabetics

Functional medicine labs help practitioners personalize treatment options for their patients. Below are some of the most common labs ordered for patients who have type 2 diabetes.

Diabetes Panel

This diabetes panel measures six biomarkers associated with diagnosing and managing dysglycemia, insulin resistance, and diabetes.

Continuous Glucose Monitoring

A continuous glucose monitor (CGM) offers a more tailored approach to blood sugar management by providing a continuous stream of blood glucose data. This helps patients and their practitioners to identify how particular foods impact blood sugar and better personalize nutritional therapy for blood sugar control.

Nutritional Assessment

Evaluating vitamins, minerals, amino acids, and fatty acids in the body with a micronutrient panel determines if insufficiencies, deficiencies, or other imbalances are present. These results will allow practitioners to make targeted diet and supplement recommendations to enhance the efficacy of their treatment plans.


Evidence-Based Diets for Type 2 Diabetes

Several ​​evidence-based diets have shown benefits in the management of type 2 diabetes.

Mediterranean Diet

The Mediterranean diet is a well-backed nutritional plan inspired by the diets of people living in the Mediterranean region. It emphasizes whole, minimally processed foods, including fruits, vegetables, whole grains, beans, nuts, seeds, fish, and olive oil. These foods are rich in fiber, healthy fats, and antioxidants. The Mediterranean diet has been associated with improved glycemic control, reduced cardiovascular risk, and weight management.

DASH (Dietary Approaches to Stop Hypertension) Diet

The DASH diet is focused on reducing sodium intake and increasing consumption of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products. This diet was initially designed to treat high blood pressure, which is important for individuals with diabetes at a higher risk of developing hypertension. Other benefits noted in those following the DASH diet include improved cholesterol, insulin sensitivity, weight loss, and overall risk reduction of heart disease (12, 13).

Evaluating Popular Diet Trends for Type 2 Diabetes

Let's discuss what the research says about other dietary trends' effects on blood sugar management and type 2 diabetes.

Low-Carbohydrate Diets (e.g., Keto, Atkins)

Low-carbohydrate diets, such as the ketogenic and Atkins diets, restrict carbohydrate intake while promoting higher fat and protein consumption. A 2021 meta-analysis evaluated the effects of low- and very low-carbohydrate diets for people with type 2 diabetes and concluded that adherence after six months may safely result in the remission of diabetes. A 2020 meta-analysis reviewing the ketogenic diet specifically noted significant improvements in weight reduction, glycemic control, and HDL cholesterol.

Plant-Based Diets (e.g., Vegetarian, Vegan)

The research also supports using plant-based, such as vegetarian or vegan, diets to manage type 2 diabetes. These diets emphasize plant foods like fruits, vegetables, whole grains, legumes, nuts, and seeds while minimizing or eliminating the consumption of animal products. A 2019 meta-analysis showed that greater adherence to a plant-based diet was associated with a 23% reduced risk of type 2 diabetes compared with low adherence. Another systematic review and meta-analysis concluded that a vegetarian diet lowered the prevalence and incidence of type 2 diabetes. However, it should be noted the certainty of the evidence was evaluated as low and supported the need for further investigations. While the evidence for diabetes prevention and treatment with a vegan diet is limited, the existing studies do support its effectiveness in reducing body weight and hemoglobin A1c values.

Intermittent Fasting

Intermittent fasting refers to regularly not eating during a repeated schedule of time. A recent 2022 systematic review and meta-analysis concluded that intermittent fasting diet intervention successfully reduces fasting blood glucose, hemoglobin A1c, insulin plasma levels, the homeostatic model assessment of insulin resistance (HOMA-IR), body mass index (BMI), waist circumference, total cholesterol, LDL cholesterol, and triglycerides. The results indicate that intermittent fasting diets have positive therapeutic effects on patients with metabolic syndrome and significantly improve insulin resistance. Compared to other dietary protocols, intermittent fasting has been shown to result in comparable reductions in hemoglobin A1c and more significant weight loss in patients with type 2 diabetes (14, 15).

Individualized Approaches to Type 2 Diabetic Nutrition

Nutrition therapy is not a one-size-fits-all approach. It should consider individual factors, such as personal preferences, cultural considerations, lifestyle, and other medical conditions. Additionally, nutrition therapy involves a collaborative effort between the patient and their healthcare providers. An individualized nutrition plan should be adjusted based on patient progress, glycemic monitoring, encountered challenges, and health goals. Educating the patient about meal planning, carbohydrate counting, label reading, and other healthy-eating strategies, healthcare providers should aim to empower their patients to make healthier and sustainable food choices to improve their long-term success.

How to Use Rupa Food Plans to Personalize Nutrition for Your Type 2 Diabetic Patients

Food Plans is a new feature offered through Rupa Health to help practitioners easily and quickly personalize meal plans for their patients in under 60 seconds. Meal plans can be customized based on the patient's caloric and nutrient needs, desired meal frequency, personal preferences, dietary plan type, and dietary restrictions. Sending patients home with a personalized weekly meal plan can reduce the stress associated with meal planning and improve patient compliance with dietary modifications.



Type 2 diabetes is a prevalent chronic condition characterized by impaired glucose metabolism and insulin resistance. This article explored key nutritional concepts to consider when implementing dietary interventions for patients with type 2 diabetes. Furthermore, it summarized the benefits of Mediterranean, DASH, low-carbohydrate, plant-based, and intermittent fasting diets on glycemic control, weight management, and cardiovascular health. It is recommended to work with a qualified healthcare provider to personalize dietary changes and develop a nutrition plan based on specific needs, preferences, and health goals.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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