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Probiotics For Multiple Sclerosis: One Study Shows Promise

Medically reviewed by 
Amitha Kalaichandran
Probiotics For Multiple Sclerosis: One Study Shows Promise

Imagine waking up each day uncertain of how your body will respond, grappling with fatigue, pain, and the unpredictability of your nervous system. This is the reality for over 1.8 million people worldwide living with Multiple Sclerosis (MS), a chronic and often debilitating disease that attacks the central nervous system. But what if the key to alleviating some of these symptoms lies not in high-tech laboratories or sophisticated drugs but in the microscopic world of gut bacteria?

Recent scientific explorations into the gut-brain axis—a complex communication network linking our digestive system to our brain—have opened a new realm of possibilities. Enter the world of probiotics, where tiny organisms hold immense potential. The focus of our story is a groundbreaking study exploring the effects of Saccharomyces boulardii, a probiotic yeast, on individuals with MS. The results? A remarkable decrease in inflammation and significant improvements in pain, fatigue, and overall quality of life.

For those living with MS, every new piece of research is a step towards reclaiming their health and independence. And for the rest of us, it's a reminder of the incredible connections between different parts of our body and how understanding these can revolutionize the way we treat diseases. So, let's dive into this fascinating study and uncover how something as small as a probiotic could make a big difference in the lives of those battling Multiple Sclerosis.


Changing How We Treat Multiple Sclerosis

The study focused on 40 individuals, all battling MS. With an average age of around 34, these were people in the prime of their lives, facing the daily challenges of a complex neurological condition.

Each participant was given a particular supplement or a placebo (a harmless pill with no active ingredients used as a control in experiments). The supplement wasn't just any pill—it was filled with Saccharomyces boulardii, a type of probiotic. Probiotics are live microorganisms, often called 'good' bacteria, that are known to benefit our health, especially our digestive system.

The participants took their respective pills for four months, a period long enough to observe any significant changes or benefits.

Researchers didn't just focus on gut health. They looked at various factors:

1. Inflammation Levels:

In MS, inflammation in the nervous system is a big problem. The study measured a specific marker in the blood known as high-sensitivity C-reactive protein (hs-CRP) to gauge inflammation.

2. Antioxidants:

These are substances that can prevent or slow damage to cells. The study measured the Total Antioxidant Capacity (TAC) in the blood.

3. Oxidative Stress:

This process can damage cells, and it's particularly relevant in many neurological diseases. Researchers looked at levels of malondialdehyde (MDA), a marker of oxidative stress.

4. Pain and Fatigue:

Using specific scales, the study evaluated changes in how much pain and fatigue the participants felt.

5. Quality of Life:

This is crucial in any treatment. The study used detailed surveys to assess participants' feelings about their overall health and well-being.

Findings of The Study

The findings were promising. Participants taking the probiotic supplement showed a significant decrease in the inflammation marker compared to those on the placebo. The probiotic group also saw a boost in their antioxidant levels.

Remarkably, those on the probiotic reported less pain and fatigue. The surveys showed that participants on the probiotic felt better overall in several aspects of daily living.

These findings suggest that something as simple as a probiotic supplement could potentially offer relief and improve the quality of life for those with MS. It opens the door to more natural, supportive treatments alongside traditional therapies.

Incorporating These Findings Into Your Life

The study on Saccharomyces boulardii and its potential benefits for Multiple Sclerosis (MS) patients is promising. But what does this mean for you, especially if you're considering probiotics either for MS or general health?

First, it's essential to know that probiotics are live microorganisms that are beneficial to our health, especially for our digestive system. They are often called 'good' or 'friendly' bacteria. Probiotics are commonly found in:

  • Fermented Foods: Such as yogurt, kefir, sauerkraut, tempeh, and kimchi. These foods are not only tasty but also a natural source of probiotics.
  • Supplements: Like the Saccharomyces boulardii used in the study. These are available in capsule, tablet, or powder forms.

If you're living with MS, the idea of using probiotics as a complementary approach might be appealing. The study showed promising results in reducing inflammation and improving quality of life. However, remember that every individual's response can vary. It's crucial to consult with your healthcare provider before starting any new supplement, especially if you have a condition like MS.

Even if you don't have MS, probiotics might still be a beneficial addition to your diet for overall gut health. However, you should aim for a balanced diet with naturally probiotic-rich foods. Consider supplements if you feel your diet might not provide enough of these good bacteria.

While the study is encouraging, it's essential to have realistic expectations. Probiotics are not a cure-all solution but can be a part of a holistic approach to health.

Adding probiotics to your diet could be a positive step for your gut health and overall well-being. However, it's essential to consult with your healthcare provider, especially if you have specific health conditions. Remember, every small step towards a balanced diet and lifestyle contributes to better health!


The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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Lab Tests in This Article


Asghari, K. M., Dolatkhah, N., Ayromlou, H., Mirnasiri, F., Dadfar, T., & Hashemian, M. (2023). The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: A randomized clinical trial. Scientific Reports, 13(1), 18577.

Cloyd, J. (2023, April 19). What’s the difference between prebiotics vs. probiotics vs. postbiotics? Rupa Health.

Gupta, S., Finelli, R., Agarwal, A., & Henkel, R. (2020). Total antioxidant capacity—Relevance, methods and clinical implications. Andrologia, 53(2).

LoBisco, S. (2022, September 16). How food affects your mood through the gut-brain axis. Rupa Health.

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017(8416763), 1–13.

World Health Organization. (2023, August 7). Multiple sclerosis. World Health Organization.

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