Herbal Medicine Fact Sheets
|
May 9, 2025

Saffron Health Benefits: What Science Says and How to Use It

Medically Reviewed by
Updated On
May 21, 2025

Imagine feeling calmer, clearer, and more energized—all from a single golden spice. Saffron (Crocus sativus L.) has been used for at least 3,000 years in culinary and medicinal traditions. Modern research confirms its value for mental, metabolic, and reproductive health.

This article explores the full range of saffron’s health benefits, from brain and heart support to skin, gut, and sexual wellness, and how to safely incorporate it into your daily routine.

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What Is Saffron?

Saffron is a tiny spice packed with lots of punch.

Saffron is a dried stigma from the Crocus sativus flower. It’s name comes from an Arabic word meaning “to become yellow.” Saffron is planted as a corm, an underground bulb-like plant stem that thrives in hot climates. 

The leaves of the saffron plant are long, grass-like, and slender. Saffron is hand-harvested in October or November when its flowers fully bloom and saffron strands (stigmas) are at their reddest. 

Saffron was historically used as a dye, perfume, spice, medicine, and religious offering; a luxury item that was a symbol of wealth. In fact, saffron is one of the world’s most expensive spices because of its labor-intensive production processes. 

Fortunately, a little bit of this spice goes a long way, as just a tiny amount of saffron infused into various dishes provides vivid, flavorful character. It has a light smoky aroma with a slightly sweet and earthy flavor. You might add saffron to seafood, meat, rice, vegetables, desserts, teas, pastas, and numerous other cuisines prepared around the globe. 

Phytochemical & Nutritional Profile

The nutritional profile of saffron includes:

  • Vitamins and minerals (micronutrients): small amounts of vitamin A, folate, vitamin C, potassium, manganese, copper, iron, zinc, potassium, magnesium, phosphorus, calcium, and more 
  • Antioxidants: crocetin, crocin, picrocrocin, safranal, kaempferol, quercetin, and other flavonoids

These nutrients work together synergistically to create saffron’s array of health and nutritional benefits. 

Scientifically Proven Health Benefits of Saffron

The following health perks linked to saffron are supported by science.

Brain, Mood, and Mental Wellness

Adding saffron to your meal plan or taking saffron supplements may help you reap the following benefits backed by research:

  • Improved anxiety and depression symptoms
  • Boosted mood (“sunshine spice” effect)
  • Enhanced memory and learning
  • Protection against Alzheimer’s disease and Parkinson’s disease
  • Improved sleep quality and duration
  • Lower risk of cognitive impairment

When consumed in recommended amounts, saffron appears to enhance your overall well-being and lessen chronic disease risks. 

Heart, Metabolic, and Digestive Health

Saffron’s antioxidant and anti-inflammatory properties support the following cardiometabolic advantages:

Saffron may lessen your risk of heart problems and diabetes complications. 

Eye and Vision Health

Crocetin and other antioxidants present in saffron appear to support enhanced eye health and visual clarity, particularly by reducing eye inflammation and lessening the risk of eye diseases (retinal degeneration, glaucoma, age-related macular edema, and others). Researchers found that saffron appears to optimize vision and may decrease intraocular pressure.

Sexual and Reproductive Health

Saffron may improve sexual satisfaction, performance, and libido. Studies found that saffron reduced erectile dysfunction (ED) in men and sexual dysfunction in women. It also reduced symptoms of premenstrual dysphoric disorder (PMDD), a severe form of PMS, and painful periods in women.

Skin, Immunity, and Anti-Aging

Because of saffron’s anti-inflammatory, anti-microbial, and anti-aging effects, it has the potential to boost skin health, lessen oxidative stress, heal wounds, and maximize immunity. 

Researchers found that saffron is beneficial for enhancing skin disease treatments and is used in creams, motions, sunscreens, and other cosmetic products. 

Studies demonstrate that saffron extract combined with avocado oil applied topically has anti-wrinkle properties and provides a safe way to rejuvenate the skin and improve its radiance. 

Cancer Prevention and Anti-Tumor Properties

Researchers suggest that saffron has anti-cancer properties, due in part to crocin and crocetin that help reduce tumor growth, enhance chemo-sensitivity in cancer cells, and optimize quality of life in people with cancer. 

They suggest that saffron has anti-cancer potential for breast, colorectal, lung, cervical, and prostate cancers, as well as glioblastoma, leukemia, and rhabdomyosarcoma. 

How to Incorporate Saffron Into Your Life

The following are ways to incorporate saffron into your lifestyle. You may use it to flavor foods or drinks or take saffron as a dietary supplement

Culinary Uses

The culinary uses of saffron include adding it to sweet and savory dishes or drinks. For example, you might sprinkle saffron on rice, paella, risotto, vegetables, meat, chicken, lamb, seafood, pasta, milk, tea, desserts, soups, and sauces.

Global Recipes That Feature Saffron

Examples of flavorful recipes featuring saffron include:

Experiment with the following drink recipes containing saffron:

Follow these steps to steep your own saffron tea.

Ingredients

  • 20 long saffron threads
  • 500 mL of water (about 2 cups)
  • 2 teaspoons of honey (optional)
  • 2 mint leaf sprigs
  • Optional add-ins: ginger, lemon, dried rose petals, cardamom, cinnamon sticks, etc.

Instructions

  1. Boil the water in a kettle.
  2. Add a pinch of saffron (20 long threads) in a small teapot. Add ginger if desired.
  3. After the water boils, count to ten. Pour it over the saffron.
  4. Let the water cool slightly.
  5. Steep for 5 minutes.
  6. Strain the tea and sweeten it with honey or add lemon (optional).
  7. Serve and enjoy!

Servings: 2 cups

Saffron as a Supplement

You can also consume saffron as a dietary supplement to reap its numerous health and nutritional perks. 

Ask your healthcare provider if supplementing with saffron is safe for you and appropriate to improve mood, reduce PMS symptoms, enhance libido or sexual function, manage blood sugar, minimize the risk of chronic diseases, or enhance skin, gut, and eye health

How to Buy High-Quality Saffron

When purchasing saffron, choose a product from well-reputable markets offering Iranian, Kashmirian, Spanish, or Afghan varieties when possible. Look for whole saffron strands with a dark red color and subtle floral smell. 

Avoid pre-ground saffron, which may not be pure saffron. Store saffron in an airtight container away from sunlight. When taking saffron supplements, choose those that have been third-party tested for purity, safety, and quality. 

Safety, Dosage, and Precautions

It’s best to use saffron in recommended doses and only under medical supervision. 

Safe Doses and Duration

Saffron is available as capsules, tablets, powders, and tinctures. While clinical doses may range from 20-400 milligrams daily, some researchers suggest that 100 milligrams per day is an effective dose. 

Ingesting up to 1.5 grams of saffron per day appears to be safe. There’s no specific guidelines for saffron use, but it may be toxic in doses of  5 grams to 10 grams. And, 10-20-gram doses could be fatal.

Potential Side Effects

Despite saffron's numerous potential health benefits, side effects might be a concern—especially when taking high doses of saffron supplements for long periods. 

Studies suggest that consuming high saffron doses of more than 10 grams could cause nausea, vertigo, headaches, diarrhea, stomach problems, GI bleeding, dry mouth, dizziness, mood changes, drowsiness, mood changes, blood in urine, numbness, and yellowed skin and eyes.

While rare, some people develop allergic reactions to saffron. And it could interact with certain medications like antidepressants, diabetes medications, or sedatives. Studies show that high levels of saffron may increase miscarriage rates in pregnant women. 

Who Should Avoid Saffron?

While ingesting small amounts of saffron in foods or teas appears to be safe for healthy individuals, it’s important to ask your doctor before taking saffron supplements—especially if you’re pregnant, breastfeeding, have a medical condition, or take medications. 

Frequently Asked Questions (FAQs)

The following information addresses frequently asked questions about saffron.

Is it safe to take saffron every day?

While it’s likely safe to use saffron daily in cooking to reap its many potential health benefits, always check with your healthcare provider before ingesting high amounts of saffron or taking saffron supplements—especially if you have a medical condition, take medications, or are pregnant or breastfeeding. 

Doses up to 1.5 grams appear to be safe, but avoid ingesting saffron doses of 5 grams or greater.

What does saffron do for your brain and mood?

Studies suggest that taking saffron may improve your mood, lessen anxiety and depression, enhance cognition and learning, improve sleep quality, and help protect against Alzheimer’s disease, Parkinson’s disease, and other neurological conditions

How long does saffron take to work?

It’s difficult to determine this. Many research studies examining the beneficial effects of saffron are several weeks or months in length.

What are the benefits of saffron tea vs supplements?

Saffron in tea versus supplements appears to offer similar effects on your health, but it depends on the amount you consume. Tea may have a calming effect on your mood and enhance relaxation. But if you don’t enjoy the taste of saffron tea, consider saffron in foods or supplements instead. 

Does saffron help with PMS and libido?

Yes, saffron appears to improve libido, reduce erectile dysfunction (ED) in men, and help ease PMS symptoms in women based on research

How much saffron is too much?

Doses of 1.5 grams appear to be safe, but more than 10 grams could have toxic effects and 10-20-gram doses might be fatal. 

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Key Takeaways

  • Saffron is a science-backed natural supplement and spice used to flavor foods and drinks. Its benefits may include improved cognitive, mental, heart, skin, sexual, digestive, and eye health—and beyond.
  • More than just a luxury spice, saffron is a holistic health enhancer and mood booster when used wisely and consistently.
  • Looking for more natural health and nutrition guides? Subscribe to our wellness newsletter or read our next guide on adaptogens. Leave your questions or experiences in the comment section below!

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Avey, T. (2011, September 14). Saffron rice. Tori Avey. https://toriavey.com/saffron-rice/#recipe

Bergo, A. (2013, February 14). Pickled saffron milk cap mushrooms. Forager | Chef. https://foragerchef.com/pickled-milkcap-mushrooms/#recipe

Bertagna, B. (2023a, December 29). Saffron for depression: How this beautiful spice can help manage low mood. Rupa Health. https://www.rupahealth.com/post/saffron-for-depression-how-this-beautiful-spice-can-help-manage-low-mood

Bertagna, B. (2023b, December 29). Saffron’s natural anti-anxiety properties and how to consume more of it. Rupa Health. https://www.rupahealth.com/post/saffrons-natural-anti-anxiety-properties-and-how-to-consume-more-of-it

Bloor, A. (2020, June 16). Saffron tea recipe (deliciously good for you). LinsFood | by Azlin Bloor. https://www.linsfood.com/saffron-tea-recipe/

Blues, K. (2025). Tagliatelle with seafood, and saffron cream sauce recipe - food.com. Food.com. https://www.food.com/recipe/tagliatelle-with-seafood-and-saffron-cream-sauce-61663

Bostan, H. B., Mehri, S., & Hosseinzadeh, H. (2017). Toxicology effects of saffron and its constituents: A review. Iranian Journal of Basic Medical Sciences, 20(2), 110–121. https://doi.org/10.22038/ijbms.2017.8230

Bourride (fish stew with aïoli). (2015, February 13). Saveur. https://www.saveur.com/article/recipes/classic-french-fish-stew-with-aioli/

Cloyd, J. (2023a, April 28). What is the difference between medical-grade supplements and over-the-counter supplements? Rupa Health. https://www.rupahealth.com/post/what-is-the-difference-between-medical-grade-supplements-and-over-the-counter-supplements

Cloyd, J. (2023b, July 5). Integrative approaches to managing high blood sugar: Specialty testing, lifestyle modifications, and natural remedies. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-managing-high-blood-sugar-testing-lifestyle-modifications-and-natural-remedies

Cloyd, J. (2024, February 28). The link between erectile dysfunction and cardiovascular disease: Understanding the connection. Rupa Health. https://www.rupahealth.com/post/the-link-between-erectile-dysfunction-and-cardiovascular-disease-understanding-the-connection

Could spicy saffron benefit your health? (2022, July 6). Cleveland Clinic. https://health.clevelandclinic.org/benefits-of-saffron

Cowboy, K. (2017, November 15). Moroccan lamb and raisin mrouzia tagine - kosher cowboy - recipes. Kosher Cowboy. https://koshercowboy.com/lamb-raisin-tagine/#recipe

Débora Cerdá-Bernad, Costa, L., Ana Teresa Serra, Maria Rosário Bronze, Estefanía Valero‐Cases, Pérez‐Llamas, F., Candela, E., Arnao, M. B., Tomás-Barberán, F. A., Rocío García Villalba, María Teresa Garcı́a-Conesa, & María José Frutos. (2022). Saffron against neuro-cognitive disorders: An overview of its main bioactive compounds, their metabolic fate and potential mechanisms of neurological protection. Nutrients, 14(24), 5368–5368. https://doi.org/10.3390/nu14245368

El Midaoui, A., Ghzaiel, I., Vervandier-Fasseur, D., Ksila, M., Zarrouk, A., Nury, T., Khallouki, F., El Hessni, A., Ibrahimi, S. O., Latruffe, N., Couture, R., Kharoubi, O., Brahmi, F., Hammami, S., Masmoudi-Kouki, O., Hammami, M., Ghrairi, T., Vejux, A., & Lizard, G. (2022). Saffron (crocus sativus L.): A source of nutrients for health and for the treatment of neuropsychiatric and age-related diseases. Nutrients, 14(3), 597. https://doi.org/10.3390/nu14030597

Ghaffari, S., & Roshanravan, N. (2019). Saffron; an updated review on biological properties with special focus on cardiovascular effects. Biomedicine & Pharmacotherapy, 109, 21–27. https://doi.org/10.1016/j.biopha.2018.10.031

Goyal, A., Raza, F. A., Sulaiman, S. A., Shahzad, A., Aaqil, S. I., Iqbal, M., Javed, B., & Pokhrel, P. (2024). Saffron extract as an emerging novel therapeutic option in reproduction and sexual health: Recent advances and future prospectives. Annals of Medicine and Surgery, 86(5), 2856. https://doi.org/10.1097/MS9.0000000000002013

How to make saffron water: Ottolenghi’s saffron water recipe - 2025 - masterclass. (2020). MasterClass. https://www.masterclass.com/articles/yotam-ottolenghis-saffron-water-recipe

https://www.facebook.com/foodandwine. (2021). Cioppino with fennel and saffron. Food & Wine. https://www.foodandwine.com/recipes/cioppino-with-fennel-and-saffron

Institute, M. S. (n.d.). Saffron. McCormick Science Institute. https://www.mccormickscienceinstitute.com/resources/culinary-spices/herbs-spices/saffron

Kashani, L., Aslzadeh, S., Shokraee, K., Shamabadi, A., Tadayon Najafabadi, B., Jafarinia, M., Esalatmanesh, S., & Akhondzadeh, S. (2022). Crocus sativus (saffron) in the treatment of female sexual dysfunction: A three-center, double-blind, randomized, and placebo-controlled clinical trial. Avicenna Journal of Phytomedicine, 12(3), 257–268. https://doi.org/10.22038/AJP.2022.19714

Kell, G., Rao, A., Beccaria, G., Clayton, P., Inarejos-García, A. M., & Prodanov, M. (2017). Affron ® a novel saffron extract ( crocus sativus L .) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine, 33, 58–64. https://doi.org/10.1016/j.ctim.2017.06.001

Kotanidou, E. P., Vasiliki Rengina Tsinopoulou, Giza, S., Stergianna Ntouma, Angeli, C., Michail Chatziandreou, Konstantinos Tsopelas, Ioulia Tseti, & Assimina Galli-Tsinopoulou. (2023). The effect of saffron kozanis (crocus sativus L.) supplementation on weight management, glycemic markers and lipid profile in adolescents with obesity: A double-blinded randomized placebo-controlled trial. Children (Basel), 10(11), 1814–1814. https://doi.org/10.3390/children10111814

Kravchuk , N. (2018, April 8). Beef plov (beef rice pilaf) recipe. NatashasKitchen.com. https://natashaskitchen.com/beef-plov-beef-rice-pilaf-recipe/

Lee, L. (2020, April 30). Saffron chia seed pudding. Rumi Spice. https://www.rumispice.com/blogs/recipes/saffron-chia-pudding-recipe#rk_parent

Lian, J., Zhong, Y., Li, H., Yang, S., Wang, J., Li, X., Zhou, X., & Chen, G. (2022). Effects of saffron supplementation on improving sleep quality: A meta-analysis of randomized controlled trials. Sleep Medicine, 92, 24–33. https://doi.org/10.1016/j.sleep.2022.03.001

ltrodrigu. (2025). Saffron mashed potatoes recipe. Keyingredient. https://www.keyingredient.com/recipes/1618815032/saffron-mashed-potatoes/

Maholy, N. (2023, May 17). A functional medicine eye health protocol: Testing, supplements, and best nutrition. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-eye-health-protocol

Nadeem, W. (2022, November 21). Saffron tea. I Knead to Eat. https://ikneadtoeat.com/saffron-tea/#recipe

Naeimifar, A., Ahmad Nasrollahi, S., Samadi, A., Talari, R., Sajad Ale‐nabi, S., Massoud Hossini, A., & Firooz, A. (2020). Preparation and evaluation of anti‐wrinkle cream containing saffron extract and avocado oil. Journal of Cosmetic Dermatology, 19(9), 2366–2373. https://doi.org/10.1111/jocd.13284

Obaldia, G. D., & Obaldia, G. D. (2020, November 10). Saffron risotto. Our Plant-Based World. https://ourplantbasedworld.com/saffron-risotto/

Perrotti, K. (2024, January 20). Saffron chicken noodle soup | tried and true recipes. Tried and True Recipes. https://www.triedandtruerecipe.com/saffron-chicken-noodle-soup/

Pinney, J. (2020, June 13). Chicken & shrimp paella - julia’s cuisine. Julia’s Cuisine. https://juliascuisine.com/payella/

Preston, J. (2023, June 21). An integrative medicine approach to food allergies: Specialty testing and treatment options. Rupa Health. https://www.rupahealth.com/post/an-integrative-medicine-approach-to-food-allergies-specialty-testing-cross-contamination-and-treatment-options

Rajabi, F., Rahimi, M., Sharbafchizadeh, M., & Tarrahi, M. (2020). Saffron for the management of premenstrual dysphoric disorder: A randomized controlled trial. Advanced Biomedical Research, 9(1), 60. https://doi.org/10.4103/abr.abr_49_20

Ranjbar, H., & Akram Ashrafizaveh. (2019). Effects of saffron (crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis. Avicenna Journal of Phytomedicine, 9(5), 419. https://pmc.ncbi.nlm.nih.gov/articles/PMC6727438/

Rashid, M., Rashid, R., Sabtain Saroya, Mrinalini Deverapalli, Brim, H., & Ashktorab, H. (2024). Saffron as a promising therapy for inflammatory bowel disease. Nutrients, 16(14), 2353–2353. https://doi.org/10.3390/nu16142353

Rigi, H., Mohtashami, L., Asnaashari, M., Emami, S. A., & Tayarani-Najaran, Z. (2021). Dermoprotective effects of saffron: A mini review. Current Pharmaceutical Design, 27(46), 4693–4698. https://doi.org/10.2174/1381612827666210920150855

Saffron uses, benefits & dosage - drugs.com herbal database. (2025, January 2). Drugs.com. https://www.drugs.com/npp/saffron.html

Sani, A., Tajik, A., Seiiedi, S. S., Khadem, R., Tootooni, H., Taherynejad, M., Sabet Eqlidi, N., Alavi dana, S. mohammad matin, & Deravi, N. (2022). A review of the anti-diabetic potential of saffron. Nutrition and Metabolic Insights, 15(15), 11786388221095223. https://doi.org/10.1177/11786388221095223

SEO, B. (2025). Saffron & rose water iced tea. The Spice House. https://www.thespicehouse.com/blogs/recipes/saffron-rose-water-iced-tea

Sepahi, S., Ghorani-Azam, A., Hossieni, S. M., Mohajeri, S. A., & Khodaverdi, E. (2021). Pharmacological effects of saffron and its constituents in ocular disorders from in vitro studies to clinical trials: A systematic review. Current Neuropharmacology, 19(3), 392–401. https://doi.org/10.2174/1570159x18666200507083346

Shaw, H. (2021, December 8). Saffron aioli recipe - how to make aioli | hank shaw. Hunter Angler Gardener Cook. https://honest-food.net/saffron-aioli-recipe/#wprm-recipe-container-24046

Sheela Verjee, Garo, E., Pelaez, S., Fertig, O., Hamburger, M., & Butterweck, V. (2017). Saffron flower extract promotes scratch wound closure of keratinocytes and enhances VEGF production. Planta Medica, 83(14/15), 1176–1183. https://doi.org/10.1055/s-0043-109002

Spain. (2023). Spanish saffron rice with garlic shrimp. Cooklist. https://cooklist.com/recipe/spanish-saffron-rice-with-garlic-shrimp-2213447

Spence, C. (2023). Saffron: The colourful spice. International Journal of Gastronomy and Food Science, 34, 100821–100821. https://doi.org/10.1016/j.ijgfs.2023.100821

Sweetnich, J. (2023, May 26). Integrative treatment options for neurological diagnosis: Specialty testing, nutrition, supplements. Rupa Health. https://www.rupahealth.com/post/4-neurological-conditions-commonly-treated-with-integrative-medicine

Vachon, P. (2023, May 11). What is saffron? | institute of culinary education. Www.ice.edu. https://www.ice.edu/blog/what-is-saffron

Vitamins and minerals of saffron. (2013). Research Gate. https://www.researchgate.net/figure/Nutritional-Vitamins-and-minerals-of-Saffron_tbl1_276453266

Walker, C. (2022, October 23). Adas polo (persian lentil rice). Proportional Plate. https://www.proportionalplate.com/adas-polo/#recipe

Wang, C.-Z., Ma, Q., Kim, S., Wang, D. H., Shoyama, Y., & Yuan, C.-S. (2022). Effects of saffron and its active constituent crocin on cancer management: A narrative review. Longhua Chinese Medicine, 5, 35–35. https://doi.org/10.21037/lcm-21-72

Yoshimura, H. (2023, October 23). Are supplements really necessary?: Pros, cons, and how testing can help. Rupa Health. https://www.rupahealth.com/post/are-supplements-really-necessary-pros-cons-and-how-testing-can-help

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