Title
Subscribe to the Magazine for free
Subscribe for free to keep reading! If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

The Science of Foods, Creating the Least Inflammatory Diet Possible With The Precision Point P-88 DIY Antigen Test

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
Medically Reviewed by

Many people realize that they are having issues with food and can tell something in their diet is affecting them. They are often led to allergy testing and may find some answers but not the entire solution. Allergy testing is useful but only looks at one way we react to foods. To best understand food reactions, you must measure multiple ways the body reacts to food. Allergy testing measures an immune response known as IgE. Our body can be inflamed in different ways, not only from IgE but also from Total IgG, IgG4, and complement.

[signup]

The P88-DIY Dietary Antigen Test measures all four of these reactions with a technology that can be utilized right from your home. The best diet is the one that is the least anti-inflammatory, and the P88-DIY Dietary Antigen Test elucidates a diet that will decrease many types of inflammation and symptoms and is foundational to wellness. When we eat the least inflammatory diet individualized to our body, we create the best odds for optimizing our chances of health. The P88-DIY Dietary Antigen Test does just this.

Improving wellness is the key to manifesting passions and staying engaged with the world around you. Inflammation, which can be created from foods, is at the heart of many conditions that are detrimental to health and quality of life. (1,2,3) Considering our gut covers the size of half a badminton court to a tennis court, stretched from end-to-end, controlling even a small amount of inflammation on something this size provides huge benefits to our health. Research continues to emerge regarding the consequences of inflammation in our gut and how foods trigger an inflammatory process throughout the body.

As inflammation decreases, the intestinal lining or "gut" begins to heal. Rebuilding the gut results in more substantial protection for the body from irritating foods. The gut contributes heavily to our "immune tolerance." A tolerant immune system is a healthy immune system, prepared to fight infection when necessary but not in a state of hyperactivity.

An out-of-balance immune system creates inflammation that can create a cascade of events, ultimately resulting in many symptoms or worsening already existing conditions. Food allergies and sensitivities are significant reasons that this can occur.

If the gut barrier breaks down, this is a condition often referred to as "leaky gut." When gaps in the lining are present, larger molecules of under-digested food enter the bloodstream. Once in circulation, The body begins to attack these food molecules. This compromises the immune system's reserves to fight bacteria, viruses, and parasites, and consequently, the body becomes inflamed for no productive reason. This results in immune confusion and causes many other inflammatory symptoms throughout the body.

Damage to the gut also decreases the number of enzymes available to help us absorb nutrients from our food, such as amylase and lipase. (4) As these enzymes break down, our ability to absorb nutrients decreases. Poor absorption of nutrients comprises every cell in the body. A feed-forward inflammatory cycle has been created.

The P88-DIY Dietary Antigen Test examines four ways the body reacts to foods so you can interrupt the inflammatory cycle.

IgE

IgE (immunoglobulin E) allergies are the immediate responses to a foreign substance that has entered the body via food or inhalation. IgE allergies can cause severe symptoms like difficulty breathing, swelling, and hives. In more serious cases, IgE reactions can lead to anaphylactic shock. The P-88 DIY Antigen Test measures the blood level of IgE, one of the five subclasses of antibodies. Antibodies are proteins made by the immune system that attack antigens such as bacteria, viruses, and allergens. They can become confused or cross-reactive and begin attacking foods we ingest, causing an allergic reaction.

IgG

IgG (immunoglobulin G, total) are antibodies that provide long-term resistance to infections and have a much longer half-life than an IgE allergy. IgG-mediated food sensitivity can be more subtle, and many people live with it for years, if not their entire lives, not realizing these foods are the reason for a decreased quality of life. Sensitivity symptoms range from fatigue, headache/nausea, seizures, hyperactivity, bloating, mood changes, or dark circles under the eyes. IgG symptoms typically occur within 3-72 hours after the offending food was ingested, making it very difficult to pinpoint the offending food without testing. These antibodies can create ongoing inflammation that can make other health conditions worse.

The degree and severity of symptoms of IgG sensitivity vary significantly from person to person because of genetic makeup. The complete elimination of IgG-positive foods may dramatically improve symptoms of irritable bowel syndrome, autism, ADHD, cystic fibrosis, rheumatoid arthritis, and epilepsy, as demonstrated in numerous clinical studies. (5-9)

It is important to get tested for food sensitivities to know what foods work for the patient's body and what foods don't. If you only look at allergies (IgE), you will miss the IgG-mediated symptoms, creating an incomplete picture and diagnosis. The DIY teases out IgG4, which has an entirely different mechanism of action and represents it separately. Precision Point Diagnostics believes that the most accurate result is created by measuring IgG 1-3 together and IgG4 separately. IgG4 blocks allergies, whereas types 1-3 increase sensitivities. Looking at individual values increases the clinical utility of the test.

IgG4

IgG4 (immunoglobulin G subtype 4) is another antibody produced to fight infection. IgG4 is used in allergy therapies to help neutralize the reaction of IgE. This is because of its potential to decrease histamine responses by blocking IgE from attaching to receptors. IgG4 is generally beneficial and will block allergic reactions from occurring. It does this by slotting into the receptor where IgE would bind and blocks it, inhibiting IgE's ability to create histamine release. However, too much IgG4 causes immune-mediated conditions, known as IgG4-RD, that typically affect multiple organ systems in the body. For these reasons, it's important to know the levels of IgG4 in the body to maintain a correct balance. An example of a tissue that is susceptible to higher levels of IgG4 is the esophagus, resulting in Eosinophilic Esophagitis. IgG4 also interferes with the thyroid, contributing to autoimmune thyroiditis, and can also cause IgG4- Related Diseases (IgG4-RD) of the ovaries and prostate.

C3D

C3D (Complement) is a protein of the innate immune system that is activated by microorganisms in the absence of an antibody. When C3d is activated in response to an antigen, the C3 portion attaches to the antigen. This activation, even though independent, will amplify the reaction that occurs with total IgG, significantly increasing inflammation and sensitivity symptoms. This same reaction which was designed to amplify inflammation in microorganisms can be triggered in response to foods. If complement is present, it will amplify an IgG reaction as much as 1000 to 10,000-fold. Therefore, tests that only measure IgG may miss the reactions to foods that are most clinically relevant. If complement is known to have a high level of reactivity in the condition you are treating, then foods that confuse and irritate this part of the immune system should be given special attention.

In addition to groundbreaking technology that measures four independent ways our body reacts to food, we also recognize that no matter how profound a technology is, if it isn't readily accessible, it will lose value. The P-88 DIY Antigen Test is the first of its kind to utilize a fingerstick technology with an activated tip that gives the ability to use a very tiny prick that is barely felt at all and gives the ability to get a large amount of specimen that allows over 350 reactions to foods to be run on a single test.

This technology was designed by a Ph.D. who saw his diabetic father suffer trying to stick his finger with larger pricks and often unable to produce enough blood. He designed a technology that uses something like a sponge for the tip of the collection device that moves blood into a tube facilitated by capillary flow dynamics. This means that the tip is active and will provide much more specimen than an average fingerstick while feeling less. Β 

Precision Point combines all four independent immune markers, IgE, IgG, IgG4, and complement, in one test that can all be done without a phlebotomist and from the convenience of your own home. Precision Point is proud to lead the field in scientific development while making the experience easier and accessible for patients everywhere. Β 

Many people notice that certain foods might not agree with them, and they may suspect that something in their diet is affecting their well-being. Allergy testing can provide some insights, but it only examines one type of reaction to foods. To gain a more comprehensive understanding of how the body responds to food, it's helpful to consider multiple types of reactions. Allergy testing typically measures an immune response known as IgE. However, the body can experience inflammation in various ways, not only from IgE but also from Total IgG, IgG4, and complement.

[signup]

The P88-DIY Dietary Antigen Test is designed to measure all four of these reactions and can be used conveniently at home. A diet that minimizes inflammation may support overall wellness, and the P88-DIY Dietary Antigen Test aims to help identify foods that might contribute to inflammation. By choosing foods that are less likely to cause inflammation, individuals may support their overall health.

Focusing on wellness can help individuals pursue their passions and stay engaged with the world. Inflammation, which can be influenced by foods, is associated with various conditions that may impact health and quality of life. (1,2,3) Considering that our gut covers a large surface area, managing inflammation in this area can be beneficial for health. Ongoing research explores the impact of inflammation in the gut and how foods may trigger inflammatory processes in the body.

As inflammation is managed, the intestinal lining or "gut" may begin to heal. A healthier gut can provide better protection against foods that might cause irritation. The gut contributes significantly to our "immune tolerance." A balanced immune system is important for maintaining health, as it can respond to infections when needed without becoming overactive.

An imbalanced immune system can lead to inflammation, which may result in various symptoms or exacerbate existing conditions. Food allergies and sensitivities are among the factors that can contribute to this imbalance.

If the gut barrier becomes compromised, a condition sometimes referred to as "leaky gut" may occur. This can allow larger molecules of partially digested food to enter the bloodstream, potentially leading to an immune response. This situation can strain the immune system's ability to address other challenges, such as bacteria, viruses, and parasites, and may lead to unnecessary inflammation.

Damage to the gut may also reduce the availability of enzymes that help absorb nutrients from food, such as amylase and lipase. (4) As these enzymes become less effective, nutrient absorption may decrease, affecting overall health.

The P88-DIY Dietary Antigen Test examines four ways the body may react to foods, potentially helping to manage the inflammatory cycle.

IgE

IgE (immunoglobulin E) allergies are immediate responses to certain substances that enter the body through food or inhalation. IgE allergies can cause symptoms like difficulty breathing, swelling, and hives. In more serious cases, IgE reactions can lead to anaphylactic shock. The P-88 DIY Antigen Test measures the blood level of IgE, one of the five subclasses of antibodies. Antibodies are proteins made by the immune system that target antigens such as bacteria, viruses, and allergens. Sometimes, these antibodies may react to foods, causing an allergic response.

IgG

IgG (immunoglobulin G, total) are antibodies that provide long-term resistance to infections and have a longer half-life than IgE allergies. IgG-mediated food sensitivity can be more subtle, and many people may not realize that certain foods are affecting their quality of life. Sensitivity symptoms can include fatigue, headache, nausea, hyperactivity, bloating, mood changes, or dark circles under the eyes. These symptoms typically occur within 3-72 hours after consuming the food, making it challenging to identify the cause without testing. These antibodies can contribute to ongoing inflammation that may affect other health conditions.

The degree and severity of IgG sensitivity symptoms can vary significantly from person to person due to genetic differences. Identifying and managing IgG-positive foods may help improve symptoms associated with various conditions, as suggested by some clinical studies. (5-9)

Testing for food sensitivities can provide insights into which foods may be more suitable for an individual. If only IgE allergies are considered, IgG-mediated symptoms might be overlooked, leading to an incomplete understanding. The DIY test also examines IgG4, which has a different mechanism and is measured separately. Precision Point Diagnostics suggests that measuring IgG 1-3 together and IgG4 separately provides a more comprehensive result. IgG4 can block allergies, while types 1-3 may increase sensitivities. Examining individual values can enhance the clinical utility of the test.

IgG4

IgG4 (immunoglobulin G subtype 4) is another antibody involved in the immune response. IgG4 is used in allergy therapies to help manage IgE reactions. It may decrease histamine responses by blocking IgE from attaching to receptors. While generally beneficial, excessive IgG4 can be associated with immune-mediated conditions, known as IgG4-RD, which may affect multiple organ systems. Monitoring IgG4 levels can help maintain a healthy balance. For example, higher levels of IgG4 can affect the esophagus, potentially leading to Eosinophilic Esophagitis, and may also impact the thyroid and other organs.

C3D

C3D (Complement) is a protein of the innate immune system that can be activated by microorganisms without the presence of an antibody. When C3d is activated in response to an antigen, it can amplify the reaction that occurs with total IgG, potentially increasing inflammation and sensitivity symptoms. This reaction, which is intended to enhance the immune response to microorganisms, can also be triggered by foods. If complement is present, it can amplify an IgG reaction significantly. Therefore, tests that only measure IgG may miss some food reactions that are clinically relevant. If complement reactivity is high, foods that may irritate this part of the immune system should be considered carefully.

In addition to its innovative technology that measures four independent ways the body may react to food, the P-88 DIY Antigen Test is designed to be accessible. It uses a fingerstick technology with an activated tip that allows for a small, minimally invasive sample collection, enabling over 350 food reactions to be tested with a single sample.

This technology was developed by a Ph.D. who wanted to help his diabetic father, who struggled with traditional fingerstick methods. The design uses a sponge-like tip that facilitates blood collection through capillary flow dynamics, providing a larger sample with less discomfort. Β 

Precision Point combines all four independent immune markers, IgE, IgG, IgG4, and complement, in one test that can be done at home without the need for a phlebotomist. Precision Point is committed to advancing scientific development while making testing more convenient and accessible for individuals. Β 

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
Learn More
No items found.

Lab Tests in This Article

  1. Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79. doi: 10.1007/s11916-019-0819-4. PMID: 31456119.
  2. Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016 Nov-Dec;36(6):386-390. doi: 10.5144/0256-4947.2016.386. PMID: 27920409; PMCID: PMC6074204.
  3. Coucke F. Food intolerance in patients with manifest autoimmunity. Observational study. Autoimmun Rev. 2018 Nov;17(11):1078-1080. doi: 10.1016/j.autrev.2018.05.011. Epub 2018 Sep 11. PMID: 30213697
  4. Shaw D, Gohil K, Basson MD. Intestinal mucosal atrophy and adaptation. World J Gastroenterol. 2012;18(44):6357-6375. doi:10.3748/wjg.v18.i44.6357
  5. Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004 Oct;53(10):1459-64. doi: 10.1136/gut.2003.037697. PMID: 15361495; PMCID: PMC1774223.
  6. Li C, Liu Y, Fang H, Chen Y, Weng J, Zhai M, Xiao T, Ke X. Study on Aberrant Eating Behaviors, Food Intolerance, and Stereotyped Behaviors in Autism Spectrum Disorder. Front Psychiatry. 2020 Nov 5;11:493695. doi: 10.3389/fpsyt.2020.493695. PMID: 33240114; PMCID: PMC7678488.
  7. Ritz BW, Lord RS. Case study: The effectiveness of a dietary supplement regimen in reducing IgG-mediated food sensitivity in ADHD. Altern Ther Health Med. 2005 May-Jun;11(3):72-5. PMID: 15943133.
  8. Panush RS. Food induced ("allergic") arthritis: clinical and serologic studies. J Rheumatol. 1990 Mar;17(3):291-4. PMID: 2332849.
  9. Tao R, Fu Z, Xiao L. Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder. Genomics Proteomics Bioinformatics. 2019 Apr;17(2):183-189. doi: 10.1016/j.gpb.2019.05.002. Epub 2019 Jun 21. PMID: 31233833; PMCID: PMC6620418.
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
See All Magazine Articles
Trusted Source
The Journal of Pediatrics
Peer Reviewed Journal
Visit Source
CDC
Government Authority
Visit Source
Office of Dietary Supplements
Government Authority
Visit Source
National Heart Lung and Blood Institute
Government Authority
Visit Source
National Institutes of Health
Government Authority
Visit Source
Clinical Infectious Diseases
Peer Reviewed Journal
Visit Source
Brain
Peer Reviewed Journal
Visit Source
The Journal of Rheumatology
Peer Reviewed Journal
Visit Source
Journal of the National Cancer Institute (JNCI)
Peer Reviewed Journal
Visit Source
Journal of Cardiovascular Magnetic Resonance
Peer Reviewed Journal
Visit Source
Hepatology
Peer Reviewed Journal
Visit Source
The American Journal of Clinical Nutrition
Peer Reviewed Journal
Visit Source
The Journal of Bone and Joint Surgery
Peer Reviewed Journal
Visit Source
Kidney International
Peer Reviewed Journal
Visit Source
The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
Visit Source
Annals of Surgery
Peer Reviewed Journal
Visit Source
The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
Visit Source
Chest
Peer Reviewed Journal
Visit Source
Blood
Peer Reviewed Journal
Visit Source
Gastroenterology
Peer Reviewed Journal
Visit Source
The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
Visit Source
The American Journal of Psychiatry
Peer Reviewed Journal
Visit Source
Diabetes Care
Peer Reviewed Journal
Visit Source
The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
Visit Source
The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
Visit Source
Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
Visit Source
Circulation
Peer Reviewed Journal
Visit Source
JAMA Internal Medicine
Peer Reviewed Journal
Visit Source
PLOS Medicine
Peer Reviewed Journal
Visit Source
Annals of Internal Medicine
Peer Reviewed Journal
Visit Source
Nature Medicine
Peer Reviewed Journal
Visit Source
The BMJ (British Medical Journal)
Peer Reviewed Journal
Visit Source
The Lancet
Peer Reviewed Journal
Visit Source
Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
Visit Source
Pubmed
Comprehensive biomedical database
Visit Source
Harvard
Educational/Medical Institution
Visit Source
Cleveland Clinic
Educational/Medical Institution
Visit Source
Mayo Clinic
Educational/Medical Institution
Visit Source
The New England Journal of Medicine (NEJM)
Peer Reviewed Journal
Visit Source
Johns Hopkins
Educational/Medical Institution
Visit Source