Nutrient Fact Sheets
|
August 13, 2024

The Truth About Red Dye 40

Medically Reviewed by
Updated On
September 17, 2024

Red Dye 40 is a food dye used to enhance the color of red foods, drinks, cosmetics, and other consumer products. Understanding food additives (particularly food dyes), their use in the food industry, and their related concerns and controversies is vital.

This article explores Red Dye 40, its potential health impacts, and how to identify products containing Red 40 and other food dyes. 

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What is Red Dye 40?

Red Dye 40 is also referred to as:

  • Red 40
  • Allura Red AC
  • Allura Red 
  • FD&C Red 40
  • E129
  • CI 16035
  • Red 40 Lake
  • FD&C Red 40 Aluminum Lake
  • Fancy Red

It's a chemical substance used to alter the color of some products and enhance their appearance. Red Dye 40 is a dark red powder. Its chemical composition is: 

  • Disodium;6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate

This food dye is manufactured by coupling 6-hydroxy-2-naphthalene sulphonic acid with diazotized 5-amino-4-methoxy-2-toluenesulfonic acid.

Historical background

Red 40 has historically been used as an additive in foods, beverages, drugs, cosmetics, industrial and household cleaning supplies, arts and crafts, office supplies, and even children's toys. 

Numerous regulatory agencies, including the European Food Safety Authority (EFSA), the United States Food and Drug Administration (FDA), and the Joint FAO/WHO Expert Committee on Food Additives (JECFA), have approved Red 40.

Is Red Dye 40 Safe?

Red Dye is deemed safe in recommended amounts, though some agencies suggest avoiding synthetic food dyes altogether. 

Regulatory Guidelines

Accepted daily intakes (ADIs) for Red 40 established by regulatory agencies include:

  • FDA: 0-7 milligrams per kilogram (mg/kg) of body weight daily
  • JECFA: 0-7 mg/kg of body weight daily
  • EFSA: 0-7 mg/kg of body weight daily

Studies found that Red 40, Yellow 5, and Yellow 6 make up 90% of the dyes used in foods

Scientific Studies and Research

Studies show potential concerns regarding Red Dye 40 and other synthetic food dyes, particularly in children and when consumed in high amounts. 

Researchers found that Red Dye 40, as well as Yellow 5 and Yellow 6, contain a human and animal carcinogen (cancer-causing substance) called benzidine, which is permitted for consumption by some regulatory agencies at low levels. 

While the FDA allows and deems food dyes safe in small amounts, they are controversial because numerous studies demonstrate potential health risks associated with their use. The most commonly consumed food dyes in products marketed toward children are Red 40, Yellow 5, Yellow 6, and Blue 1.

Detailed Mechanisms

Animal studies found that Red Dye 40 is present in feces (29%) and urine (0.1%). The gut flora breaks down the dye into 1-amino-2-naphthol-6-sulfonic acid and cresidine-4-sulfonic acid. 

Animal studies show that within 72 hours of consuming Red 40, 92-95% (dogs) and 76-92% (rats) of the dye was excreted in the feces and urine, while the gut still contained a significant amount of dye metabolites. 

Potential Health Effects of Red Dye 40

Despite the FDA, JECFA, and EFSA approving Red Dye 40, this food dye may pose several health risks, mainly when eaten in large amounts or by children.

Allergic Reactions and Sensitivities

People who are sensitive to Red Dye 40 may have allergic reactions or other symptoms, including:

The prevalence of color additive-related allergies is 1-2% in children and less than 1% in adults. Risk factors for developing allergic reactions include:

  • Genetics
  • Consuming large amounts of food dyes
  • Having other allergies or related conditions

Behavioral Effects on Children

Studies have linked Red Dye 40 and other synthetic dyes with attention-deficit/hyperactivity disorder (ADHD) and increased hyperactivity in children. Such studies report that artificial food dyes aren't necessarily a cause of ADHD; they appear to be linked to hyperactivity in all children, not just those with diagnosed ADHD.

A review found a link between Red 40 and other food dyes and hyperactivity and potentially autism in children. 

The American Academy of Pediatrics recommends urgent reforms to the United States Additive regulatory process because of growing evidence that food coloring chemicals may harm children's health.

Other Potential Side Effects

Other potential side effects linked to Red Dye 40 include:

Red 40 causes DNA damage, microbiome changes, and colon inflammation in mice, which may account for potential gastrointestinal issues. 

The Center for Science in the Public Interest recommends avoiding adding Red Dye 40 to foods because of potential adverse side effects.

Long-Term Health Concerns

Red Dye 40 contains a cancer-causing substance called benzene. Studies confirm that Red 40 and other food dyes contain cancer-causing substances. The researchers recommend improved regulation of food dyes, better independent toxicity testing, and future approval for only well-tested, safe dyes. 

Because of the potential health effects of Red 40, some experts recommend limiting exposure to this food dye as much as possible. 

Identifying Red Dye 40 in Foods

The following information helps identify foods and other products containing Red Dye 40.

Common Foods Containing Red Dye 40

Foods, drugs, and cosmetics that may contain Red Dye 40 are as follows:

  • Cereals
  • Pastries, cakes, frostings, and other baked goods
  • Sugars, candies, chewing gums, confections, and some chocolate
  • Gelatins, puddings, and custards
  • Popsicles
  • Sports drinks, energy drinks, and sodas
  • Protein powders
  • Chips and other salty snack foods
  • Sauces and toppings
  • Some dairy foods (frozen yogurts, flavored milk, yogurts, sherbet, ice creams)
  • Fruits, juices, and fruit gummy snacks
  • Jams, jellies, and condiments
  • Some meat and poultry

Other Products Containing Red 40

  • Medications
  • Vitamins
  • Cosmetics
  • Arts and craft supplies
  • Cleaning products
  • Laundry detergents 
  • Fragrances
  • Tobacco products

Red 40 is the most commonly used food dye. It's found in some prenatal vitamins and many children's products, including vitamins, pain relievers, allergy medicines, and cough and cold syrups. 

Reading Food Labels

Look for other names associated with Red Dye 40, including:

  • Allura Red AC
  • FD&C Red No. 40
  • Red 40
  • Red 40 Lake
  • Fancy red
  • FD&C Red No. 40 Aluminum Lake
  • Allura Red AC
  • CI 16035
  • INS No. 129
  • E129
  • CI Food Red 17

Identifying Red Dye 40 in foods and other products is as simple as reading the ingredient lists.

Foods to Avoid for Sensitive Individuals

Individuals sensitive to Red Dye 40 and those desiring limited exposure for health reasons should avoid colored candies, frostings, and other highly processed foods containing bright colors. 

Examples of name-brand products often containing Red Dye 40 include Doritos, Skittles, Gatorade, and Twizzlers. 

Regulations and Controversies

There are various Red Dye 40 regulations and controversies to note.

Global Regulations

There are regulatory differences about Red Dye 40, as some countries, including the United Kingdom and Australia, have banned Red 40 and Red 3 because of potential health concerns. 

Regulatory Actions and History

Regulatory changes and actions often occur as new studies emerge and consumer advocate groups file petitions to the FDA and other agencies. For example, the California Food Safety Act prohibits distributing and selling foods containing potassium bromate, brominated vegetable oil, propylparaben, and Red 3. 

Public Perception and Media Coverage

Common misconceptions regarding FDA-approved ingredients include that no health concerns exist. Media outlets often dramatically influence public opinions, which, over time, may lead to regulatory changes in the food industry. 

Alternatives to Red Dye 40

Alternatives to Red Dye 40 include:

Natural Food Colorings

Natural dyes can often be substituted for synthetic dyes. Examples include:

  • Beet juice or beet powder
  • Blueberry and pomegranate juices
  • Turmeric
  • Beta-carotene
  • Cherries, cranberries, or strawberries
  • Dried hibiscus flowers

A benefit of using natural food dyes is that they're typically sourced from foods or other natural ingredients rather than chemicals. However, these natural ingredients may not color foods as effectively or might alter a food's flavor, and they are often more expensive

Synthetic Alternatives

Other synthetic red dyes, such as Red 3, are sometimes used instead of Red 40. However, many of the same health concerns exist. The FDA requires certifying Red 3 before use in foods. This means chemists must analyze a sample from Red 3 batches to ensure it meets purity and composition requirements, as studies show Red 3 causes cancer in animals. 

Furthermore, Red 3 is banned in cosmetics and foods in many other countries — but not in the United States.

Practical Advice for Consumers

Consider the following practical advice regarding the use of Red Dye 40.

Tips for Avoiding Synthetic Dyes

When shopping for foods and drinks, avoid choosing highly processed, brightly colored items. Read the ingredient list on food labels and choose organic products whenever possible. Consider preparing homemade alternatives versus processed foods containing dyes. 

Dietary Considerations for Children and Sensitive Individuals

Managing dietary intake can help reduce the intake of Red Dye 40. Choose whole, fresh foods instead of processed foods. Become more aware of dye-containing foods, read food labels consistently, and monitor and address hyperactivity or other symptoms potentially linked to food dyes — particularly among children. 

Consumer Advocacy and Industry Response

Increased awareness has historically led to changes in the food industry. 

Overview of Consumer Advocacy Efforts

Consumer and advocacy groups, such as the Environmental Working Group and the Center for Science in the Public Interest, recommend removing cancer-causing food dyes from foods altogether because of potential health concerns. 

Industry Response

Industry responses have been to market dye-free products and alter formulations to eliminate Red Dye 40 and other synthetic dyes.

Current Research Trends

Ongoing human and animal research is needed, which may affect the future directions of regulatory agencies. Emerging alternatives and innovations in food coloring should be considered. 

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Key Takeaways

  • Red Dye 40 is the most commonly consumed food dye that adds a rich red color to foods, drinks, and other consumer products.
  • However, Red 40 and other food dyes are linked to cancer, hyperactivity, allergic reactions, and other potential health issues. 
  • While the FDA, EFSA, and JECFA have approved Red Dye 40 for limited use, many health experts recommend avoiding it or limiting its use as much as possible.
  • Natural food colorant alternatives are available in place of Red Dye 40. 
  • Monitor future regulatory actions, potential guideline changes, and new studies involving Red Dye 40 and other commonly consumed food dyes (Yellow 5, Yellow 6, Red 3, Green 3, Blue 1, and Blue 2).

Red Dye 40 is a food dye used to enhance the color of red foods, drinks, cosmetics, and other consumer products. Understanding food additives (particularly food dyes), their use in the food industry, and their related concerns and controversies is vital.

This article explores Red Dye 40, its potential health impacts, and how to identify products containing Red 40 and other food dyes. 

[signup]

What is Red Dye 40?

Red Dye 40 is also referred to as:

  • Red 40
  • Allura Red AC
  • Allura Red 
  • FD&C Red 40
  • E129
  • CI 16035
  • Red 40 Lake
  • FD&C Red 40 Aluminum Lake
  • Fancy Red

It's a chemical substance used to alter the color of some products and enhance their appearance. Red Dye 40 is a dark red powder. Its chemical composition is: 

  • Disodium;6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate

This food dye is manufactured by coupling 6-hydroxy-2-naphthalene sulphonic acid with diazotized 5-amino-4-methoxy-2-toluenesulfonic acid.

Historical background

Red 40 has historically been used as an additive in foods, beverages, drugs, cosmetics, industrial and household cleaning supplies, arts and crafts, office supplies, and even children's toys. 

Numerous regulatory agencies, including the European Food Safety Authority (EFSA), the United States Food and Drug Administration (FDA), and the Joint FAO/WHO Expert Committee on Food Additives (JECFA), have approved Red 40.

Is Red Dye 40 Safe?

Red Dye is deemed safe in recommended amounts, though some agencies suggest avoiding synthetic food dyes altogether. 

Regulatory Guidelines

Accepted daily intakes (ADIs) for Red 40 established by regulatory agencies include:

  • FDA: 0-7 milligrams per kilogram (mg/kg) of body weight daily
  • JECFA: 0-7 mg/kg of body weight daily
  • EFSA: 0-7 mg/kg of body weight daily

Studies found that Red 40, Yellow 5, and Yellow 6 make up 90% of the dyes used in foods

Scientific Studies and Research

Studies show potential concerns regarding Red Dye 40 and other synthetic food dyes, particularly in children and when consumed in high amounts. 

Researchers found that Red Dye 40, as well as Yellow 5 and Yellow 6, contain a human and animal carcinogen (cancer-causing substance) called benzidine, which is permitted for consumption by some regulatory agencies at low levels. 

While the FDA allows and deems food dyes safe in small amounts, they are controversial because numerous studies demonstrate potential health risks associated with their use. The most commonly consumed food dyes in products marketed toward children are Red 40, Yellow 5, Yellow 6, and Blue 1.

Detailed Mechanisms

Animal studies found that Red Dye 40 is present in feces (29%) and urine (0.1%). The gut flora breaks down the dye into 1-amino-2-naphthol-6-sulfonic acid and cresidine-4-sulfonic acid. 

Animal studies show that within 72 hours of consuming Red 40, 92-95% (dogs) and 76-92% (rats) of the dye was excreted in the feces and urine, while the gut still contained a significant amount of dye metabolites. 

Potential Health Effects of Red Dye 40

Despite the FDA, JECFA, and EFSA approving Red Dye 40, this food dye may pose several health risks, mainly when eaten in large amounts or by children.

Allergic Reactions and Sensitivities

People who are sensitive to Red Dye 40 may have allergic reactions or other symptoms, including:

The prevalence of color additive-related allergies is 1-2% in children and less than 1% in adults. Risk factors for developing allergic reactions include:

  • Genetics
  • Consuming large amounts of food dyes
  • Having other allergies or related conditions

Behavioral Effects on Children

Studies have linked Red Dye 40 and other synthetic dyes with attention-deficit/hyperactivity disorder (ADHD) and increased hyperactivity in children. Such studies report that artificial food dyes aren't necessarily a cause of ADHD; they appear to be linked to hyperactivity in all children, not just those with diagnosed ADHD.

A review found a link between Red 40 and other food dyes and hyperactivity and potentially autism in children. 

The American Academy of Pediatrics recommends urgent reforms to the United States Additive regulatory process because of growing evidence that food coloring chemicals may harm children's health.

Other Potential Side Effects

Other potential side effects linked to Red Dye 40 include:

Red 40 causes DNA damage, microbiome changes, and colon inflammation in mice, which may account for potential gastrointestinal issues. 

The Center for Science in the Public Interest recommends avoiding adding Red Dye 40 to foods because of potential adverse side effects.

Long-Term Health Concerns

Red Dye 40 contains a cancer-causing substance called benzene. Studies confirm that Red 40 and other food dyes contain cancer-causing substances. The researchers recommend improved regulation of food dyes, better independent toxicity testing, and future approval for only well-tested, safe dyes. 

Because of the potential health effects of Red 40, some experts recommend limiting exposure to this food dye as much as possible. 

Identifying Red Dye 40 in Foods

The following information helps identify foods and other products containing Red Dye 40.

Common Foods Containing Red Dye 40

Foods, drugs, and cosmetics that may contain Red Dye 40 are as follows:

  • Cereals
  • Pastries, cakes, frostings, and other baked goods
  • Sugars, candies, chewing gums, confections, and some chocolate
  • Gelatins, puddings, and custards
  • Popsicles
  • Sports drinks, energy drinks, and sodas
  • Protein powders
  • Chips and other salty snack foods
  • Sauces and toppings
  • Some dairy foods (frozen yogurts, flavored milk, yogurts, sherbet, ice creams)
  • Fruits, juices, and fruit gummy snacks
  • Jams, jellies, and condiments
  • Some meat and poultry

Other Products Containing Red 40

  • Medications
  • Vitamins
  • Cosmetics
  • Arts and craft supplies
  • Cleaning products
  • Laundry detergents 
  • Fragrances
  • Tobacco products

Red 40 is the most commonly used food dye. It's found in some prenatal vitamins and many children's products, including vitamins, pain relievers, allergy medicines, and cough and cold syrups. 

Reading Food Labels

Look for other names associated with Red Dye 40, including:

  • Allura Red AC
  • FD&C Red No. 40
  • Red 40
  • Red 40 Lake
  • Fancy red
  • FD&C Red No. 40 Aluminum Lake
  • Allura Red AC
  • CI 16035
  • INS No. 129
  • E129
  • CI Food Red 17

Identifying Red Dye 40 in foods and other products is as simple as reading the ingredient lists.

Foods to Avoid for Sensitive Individuals

Individuals sensitive to Red Dye 40 and those desiring limited exposure for health reasons should avoid colored candies, frostings, and other highly processed foods containing bright colors. 

Examples of name-brand products often containing Red Dye 40 include Doritos, Skittles, Gatorade, and Twizzlers. 

Regulations and Controversies

There are various Red Dye 40 regulations and controversies to note.

Global Regulations

There are regulatory differences about Red Dye 40, as some countries, including the United Kingdom and Australia, have banned Red 40 and Red 3 because of potential health concerns. 

Regulatory Actions and History

Regulatory changes and actions often occur as new studies emerge and consumer advocate groups file petitions to the FDA and other agencies. For example, the California Food Safety Act prohibits distributing and selling foods containing potassium bromate, brominated vegetable oil, propylparaben, and Red 3. 

Public Perception and Media Coverage

Common misconceptions regarding FDA-approved ingredients include that no health concerns exist. Media outlets often dramatically influence public opinions, which, over time, may lead to regulatory changes in the food industry. 

Alternatives to Red Dye 40

Alternatives to Red Dye 40 include:

Natural Food Colorings

Natural dyes can often be substituted for synthetic dyes. Examples include:

  • Beet juice or beet powder
  • Blueberry and pomegranate juices
  • Turmeric
  • Beta-carotene
  • Cherries, cranberries, or strawberries
  • Dried hibiscus flowers

A benefit of using natural food dyes is that they're typically sourced from foods or other natural ingredients rather than chemicals. However, these natural ingredients may not color foods as effectively or might alter a food's flavor, and they are often more expensive

Synthetic Alternatives

Other synthetic red dyes, such as Red 3, are sometimes used instead of Red 40. However, many of the same health concerns exist. The FDA requires certifying Red 3 before use in foods. This means chemists must analyze a sample from Red 3 batches to ensure it meets purity and composition requirements, as studies show Red 3 causes cancer in animals. 

Furthermore, Red 3 is banned in cosmetics and foods in many other countries — but not in the United States.

Practical Advice for Consumers

Consider the following practical advice regarding the use of Red Dye 40.

Tips for Avoiding Synthetic Dyes

When shopping for foods and drinks, consider choosing less processed, less brightly colored items. Read the ingredient list on food labels and choose organic products whenever possible. Consider preparing homemade alternatives versus processed foods containing dyes. 

Dietary Considerations for Children and Sensitive Individuals

Managing dietary intake can help reduce the intake of Red Dye 40. Choose whole, fresh foods instead of processed foods. Become more aware of dye-containing foods, read food labels consistently, and monitor and address hyperactivity or other symptoms potentially linked to food dyes — particularly among children. 

Consumer Advocacy and Industry Response

Increased awareness has historically led to changes in the food industry. 

Overview of Consumer Advocacy Efforts

Consumer and advocacy groups, such as the Environmental Working Group and the Center for Science in the Public Interest, recommend removing certain food dyes from foods altogether because of potential health concerns. 

Industry Response

Industry responses have been to market dye-free products and alter formulations to eliminate Red Dye 40 and other synthetic dyes.

Current Research Trends

Ongoing human and animal research is needed, which may affect the future directions of regulatory agencies. Emerging alternatives and innovations in food coloring should be considered. 

[signup]

Key Takeaways

  • Red Dye 40 is the most commonly consumed food dye that adds a rich red color to foods, drinks, and other consumer products.
  • However, Red 40 and other food dyes are linked to cancer, hyperactivity, allergic reactions, and other potential health issues. 
  • While the FDA, EFSA, and JECFA have approved Red Dye 40 for limited use, many health experts recommend avoiding it or limiting its use as much as possible.
  • Natural food colorant alternatives are available in place of Red Dye 40. 
  • Monitor future regulatory actions, potential guideline changes, and new studies involving Red Dye 40 and other commonly consumed food dyes (Yellow 5, Yellow 6, Red 3, Green 3, Blue 1, and Blue 2).
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Peer Reviewed Journal
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Annals of Surgery
Peer Reviewed Journal
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Chest
Peer Reviewed Journal
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The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
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Blood
Peer Reviewed Journal
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Gastroenterology
Peer Reviewed Journal
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The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
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The American Journal of Psychiatry
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Diabetes Care
Peer Reviewed Journal
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The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
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The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
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Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
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Circulation
Peer Reviewed Journal
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JAMA Internal Medicine
Peer Reviewed Journal
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PLOS Medicine
Peer Reviewed Journal
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Annals of Internal Medicine
Peer Reviewed Journal
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Nature Medicine
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The BMJ (British Medical Journal)
Peer Reviewed Journal
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The Lancet
Peer Reviewed Journal
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Journal of the American Medical Association (JAMA)
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Pubmed
Comprehensive biomedical database
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Harvard
Educational/Medical Institution
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Cleveland Clinic
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Mayo Clinic
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The New England Journal of Medicine (NEJM)
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Johns Hopkins
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Hey Practitioners! On December 11th, join Dr. Terry Wahls in a free live class where she'll share her groundbreaking methods for managing MS and autoimmune patients. This live session will address your most pressing questions and will take a closer look at treatment options beyond the conventional standards of care. Register here.

Register Here