Title
Subscribe to the Magazine for free
Subscribe for free to keep reading! If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.

Toxin Testing 101: The Different Types of Toxin Testing & How to Get Started

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
Medically Reviewed by

Toxins can be found in a variety of everyday products, but the toxic particulates from wildfire smoke and the toxins and molds found in indoor air have led to increased toxin exposure for many people. These toxins cause a variety of health issues, including increased inflammation and decreased immunity. Needless to say, adequate detoxification is crucial for immune health!

So how to get started with testing?

We’ve partnered with Dr. Amy Nett MD, IFMCP to explain how she approaches toxin testing & targeted detoxification. Dr. Nett presented at the 28th Annual A4M World Congress. In case you missed it, we’re sharing the testing highlights below and will also be linking to her talk, “Immune Resilience in a Toxic World: How to Build Targeted Testing & Detoxification Plans”, once the recording is available!


Step 1: Start with comprehensive blood work & gut testing.

Testing for toxins should begin with comprehensive blood work and gut testing.

For comprehensive blood work, pay particular attention to kidney and liver markers. Check nutrient markers, and also inflammatory markers like CRP-hs.

For gut testing, try a stool analysis, SIBO Breath test, an organic acids test, and an intestinal permeability assessment.

Step 2: Add further testing if needed: Mycotoxins, Environmental Toxins, Heavy Metals.

Depending on these results and the patient’s symptoms, further testing can be performed to detect urinary mycotoxins, environmental toxins, and/or heavy metals. These are the three main toxin categories for testing. These tests usually require stool, blood, or urine samples and are typically analyzed via liquid chromatography and mass spectrometry.

Another Option: Testing for oxidative stress, 8-hydroxy-2’-deoxyguanosine (8-OHdG).

8-OHdG is one of the major products of DNA oxidation, serving as a biomarker of oxidative stress. High levels may be associated with increased risk of cancers, Alzheimer’s and rheumatoid arthritis.

While you won’t know the source of the toxicity, you’ll be able to detect the presence of it, and can start a detox protocol from there. This is a great method if the toxin testing isn’t showing toxicity, however the patient is experiencing symptoms (the “description doesn’t match the picture”) or if the patient is not able to afford the specialty toxin testing.

[youtube]

Some labs that offer oxidative stress include: Doctor’s Data’s 8-OHdG marker, Genova’s Oxidative Stress Profile and Organix Comprehensive Panel, and Precision Analytical as part of the DUTCH Plus and DUTCH Complete panels.

When deciding on testing, we know it can be overwhelming with so many options! Our partner labs offer a variety of tests, so we created these quick comparison guides for you below.

Here are the most common toxin tests we’ve seen practitioners order through the Rupa Labs Portal.

Gut Health Testing

1. Stool

2. SIBO

3. Organic Acids

4. Intestinal Permeability

Toxin Testing

1. Urinary Mycotoxins

2. Environmental Toxins

3. Heavy Metals

To dive in deeper, watch Dr. Nett’s presentation!

Toxins can be found in a variety of everyday products, and exposure to particulates from wildfire smoke and indoor air pollutants may contribute to increased toxin exposure for many people. These toxins might be associated with various health concerns, such as increased inflammation and changes in immune function. Supporting the body's natural detoxification processes is important for maintaining overall health!

So how to get started with testing?

We’ve partnered with Dr. Amy Nett MD, IFMCP to explain how she approaches toxin testing & targeted detoxification. Dr. Nett presented at the 28th Annual A4M World Congress. In case you missed it, we’re sharing the testing highlights below and will also be linking to her talk, “Immune Resilience in a Toxic World: How to Build Targeted Testing & Detoxification Plans”, once the recording is available!


Step 1: Start with comprehensive blood work & gut testing.

Testing for toxins can begin with comprehensive blood work and gut testing.

For comprehensive blood work, pay particular attention to kidney and liver markers. Check nutrient markers, and also inflammatory markers like CRP-hs.

For gut testing, consider a stool analysis, SIBO Breath test, an organic acids test, and an intestinal permeability assessment.

Step 2: Add further testing if needed: Mycotoxins, Environmental Toxins, Heavy Metals.

Depending on these results and the individual’s symptoms, further testing can be performed to detect urinary mycotoxins, environmental toxins, and/or heavy metals. These are the three main toxin categories for testing. These tests usually require stool, blood, or urine samples and are typically analyzed via liquid chromatography and mass spectrometry.

Another Option: Testing for oxidative stress, 8-hydroxy-2’-deoxyguanosine (8-OHdG).

8-OHdG is one of the major products of DNA oxidation, serving as a biomarker of oxidative stress. High levels may be associated with increased risk of certain health conditions.

While you won’t know the source of the toxicity, you’ll be able to detect the presence of it, and can start a detox protocol from there. This is a great method if the toxin testing isn’t showing toxicity, however the individual is experiencing symptoms (the “description doesn’t match the picture”) or if the individual is not able to afford the specialty toxin testing.

[youtube]

Some labs that offer oxidative stress include: Doctor’s Data’s 8-OHdG marker, Genova’s Oxidative Stress Profile and Organix Comprehensive Panel, and Precision Analytical as part of the DUTCH Plus and DUTCH Complete panels.

When deciding on testing, we know it can be overwhelming with so many options! Our partner labs offer a variety of tests, so we created these quick comparison guides for you below.

Here are the most common toxin tests we’ve seen practitioners order through the Rupa Labs Portal.

Gut Health Testing

1. Stool

2. SIBO

3. Organic Acids

4. Intestinal Permeability

Toxin Testing

1. Urinary Mycotoxins

2. Environmental Toxins

3. Heavy Metals

To dive in deeper, watch Dr. Nett’s presentation!

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
Learn More
No items found.

Lab Tests in This Article

No lab tests!
Subscribe to the Magazine for free to keep reading!
Subscribe for free to keep reading, If you are already subscribed, enter your email address to log back in.
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
Are you a healthcare practitioner?
Thanks for subscribing!
Oops! Something went wrong while submitting the form.
See All Magazine Articles
Trusted Source
Rupa Health
Medical Education Platform
Visit Source
American Cancer Society
Foundation for Cancer Research
Visit Source
National Library of Medicine
Government Authority
Visit Source
Journal of The American College of Radiology
Peer Reviewed Journal
Visit Source
National Cancer Institute
Government Authority
Visit Source
World Health Organization (WHO)
Government Authority
Visit Source
The Journal of Pediatrics
Peer Reviewed Journal
Visit Source
CDC
Government Authority
Visit Source
Office of Dietary Supplements
Government Authority
Visit Source
National Heart Lung and Blood Institute
Government Authority
Visit Source
National Institutes of Health
Government Authority
Visit Source
Clinical Infectious Diseases
Peer Reviewed Journal
Visit Source
Brain
Peer Reviewed Journal
Visit Source
The Journal of Rheumatology
Peer Reviewed Journal
Visit Source
Journal of the National Cancer Institute (JNCI)
Peer Reviewed Journal
Visit Source
Journal of Cardiovascular Magnetic Resonance
Peer Reviewed Journal
Visit Source
Hepatology
Peer Reviewed Journal
Visit Source
The American Journal of Clinical Nutrition
Peer Reviewed Journal
Visit Source
The Journal of Bone and Joint Surgery
Peer Reviewed Journal
Visit Source
Kidney International
Peer Reviewed Journal
Visit Source
The Journal of Allergy and Clinical Immunology
Peer Reviewed Journal
Visit Source
Annals of Surgery
Peer Reviewed Journal
Visit Source
Chest
Peer Reviewed Journal
Visit Source
The Journal of Neurology, Neurosurgery & Psychiatry
Peer Reviewed Journal
Visit Source
Blood
Peer Reviewed Journal
Visit Source
Gastroenterology
Peer Reviewed Journal
Visit Source
The American Journal of Respiratory and Critical Care Medicine
Peer Reviewed Journal
Visit Source
The American Journal of Psychiatry
Peer Reviewed Journal
Visit Source
Diabetes Care
Peer Reviewed Journal
Visit Source
The Journal of the American College of Cardiology (JACC)
Peer Reviewed Journal
Visit Source
The Journal of Clinical Oncology (JCO)
Peer Reviewed Journal
Visit Source
Journal of Clinical Investigation (JCI)
Peer Reviewed Journal
Visit Source
Circulation
Peer Reviewed Journal
Visit Source
JAMA Internal Medicine
Peer Reviewed Journal
Visit Source
PLOS Medicine
Peer Reviewed Journal
Visit Source
Annals of Internal Medicine
Peer Reviewed Journal
Visit Source
Nature Medicine
Peer Reviewed Journal
Visit Source
The BMJ (British Medical Journal)
Peer Reviewed Journal
Visit Source
The Lancet
Peer Reviewed Journal
Visit Source
Journal of the American Medical Association (JAMA)
Peer Reviewed Journal
Visit Source
Pubmed
Comprehensive biomedical database
Visit Source
Harvard
Educational/Medical Institution
Visit Source
Cleveland Clinic
Educational/Medical Institution
Visit Source
Mayo Clinic
Educational/Medical Institution
Visit Source
The New England Journal of Medicine (NEJM)
Peer Reviewed Journal
Visit Source
Johns Hopkins
Educational/Medical Institution
Visit Source