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A Functional Medicine Approach to Sinusitis

Medically reviewed by 
A Functional Medicine Approach to Sinusitis

Have you ever experienced pain and pressure in your sinuses? You're not alone. According to the Centers for Disease Control and Prevention, approximately 30 million adults in the United States are diagnosed with sinusitis every year. Sinusitis is a common condition affecting the sinuses, which are the air-filled spaces in the face and skull bones. When the sinuses become inflamed or infected, it can cause uncomfortable symptoms such as facial pain, pressure, and congestion. While conventional treatments such as antibiotics and decongestants can be effective, they may have side effects or fail to resolve the underlying issue fully. As such, exploring functional medicine approaches and complementary and alternative therapies may offer relief and support overall health.


What is Sinusitis?

Sinusitis, also known as a sinus infection, is a condition that causes inflammation and swelling of the sinuses. A bacterial or viral infection, allergies, or structural issues in the sinuses can cause inflammation. There are several different types of sinusitis:

  • Acute sinusitis (lasting less than four weeks)
  • Subacute sinusitis (four to 12 weeks)
  • Chronic sinusitis (lasting more than 12 weeks)
  • Recurrent sinusitis (multiple episodes of acute sinusitis within a year)

Although viruses are the primary culprit behind acute sinusitis, most chronic and severe cases can be attributed to bacterial infections.

Sinusitis Symptoms

The symptoms of sinusitis can vary depending on the type and severity of the condition. These symptoms are often similar to those of the common cold. In some cases, the symptoms of sinusitis can be severe enough to affect daily life. Common symptoms include (4,5):

  • Facial pain and pressure
  • Post-nasal drip (when mucus drips down the back of your throat)
  • Headache
  • Nasal congestion and discharge
  • Fatigue
  • Bad breath
  • Cough
  • Sore throat
  • Loss of smell or taste
  • Fever

What Causes Sinusitis?

Sinusitis, also known as a sinus infection, is caused by an inflammation or swelling of the tissue lining the sinuses. This can be due to a variety of factors including:


Allergies can cause sinusitis due to the body's immune system's response to allergens. When an allergen, such as pollen, dust, or pet dander, enters the body, the immune system can overreact and trigger an allergic response. Allergies can also cause the sinuses to produce excess mucus, making it easier for bacteria to grow and increasing sinusitis risk. As a result, individuals with allergies may be more prone to developing sinusitis, particularly during allergy season or when exposed to environmental allergens. In addition, if a person has food sensitivities, inflammation caused by this can weaken the immune system and make it more susceptible to infections, including sinus infections.

Immune System Dysfunction

One potential cause of sinusitis is a compromised immune system. Stress is a common experience that can cause physical and psychological changes in the body. Chronic stress can lead to a condition known as adrenal fatigue, where the adrenal glands cannot produce sufficient hormones. This can result in disruptions in sleep patterns and weakened immune system function, which makes us more vulnerable to infections. The immune system's ability to fight off infections is significantly compromised when we experience chronic stress, leaving us more susceptible to illnesses like sinusitis.

Environmental Irritants

Exposure to toxins and environmental pollutants can also diminish immune function, with the effects potentially lasting generations. Environmental irritants like air pollution, cigarette smoke, or chemical fumes can irritate the nasal passages and sinuses, leading to inflammation and swelling. This can obstruct the flow of mucus and cause a buildup of pressure in the sinuses, which can lead to sinusitis. Additionally, exposure to environmental irritants can weaken the immune system, making it more difficult for the body to fight off infections that may cause sinusitis.


Chronic inflammation can also contribute to sinusitis by weakening the immune system. Chronic inflammation can result from various factors, including a diet high in inflammatory foods, exposure to environmental toxins, and stress.

Dental infections

While not commonly discussed, infections in the oral cavity can spread to the sinuses which is called odontogenic sinusitis. It is suggested that approximately 30% of cases of unilateral maxillary sinusitis may have an underlying dental pathology. Symptoms of odontogenic sinusitis varies, but most commonly includes symptoms of facial pain or pressure, postnasal drip, nasal congestion, purulent anterior rhinorrhea, foul smell or taste, inflammation or bleeding of the gums, and/or bad breath.

Gut Health and Diet

As mentioned earlier, weakened immune function can increase the risk of sinusitis and other infections. One possible cause of impaired immunity is poor gut health. The gut contains the body's largest immune network, and its health is crucial for effective protection against harmful pathogens. Moreover, research suggests that gut and sinus health are interrelated. For example, when harmful bacteria overgrow or lack diversity in the sinuses, it can lead to inflammation and infection. Therefore, maintaining a healthy gut can help improve our immune system function, reducing the risk of sinusitis and other infections.

Diet can also play a role in the development of sinusitis. Foods high in sugar, processed foods, and dairy products have been linked to increased inflammation in the body, exacerbating sinusitis symptoms. In addition, for your immune system to function properly, sufficient levels of micronutrients are needed. Studies have shown that suboptimal levels impact infection rates and general immunity, which could put you at a higher risk for sinusitis.

Functional Medicine Labs to Test for Root Cause of Sinusitis

Rupa Health offers several lab tests that can help identify the root cause of sinusitis and guide personalized treatment. Some examples are:

Comprehensive Stool Testing

Comprehensive Stool Testing via GI-MAP by Diagnostic Solutions: this test utilizes quantitative polymerase chain reaction (qPCR) technology to detect highly sensitive microbial DNA. This test provides comprehensive information about the microbiome by identifying pathogenic bacteria, viruses, and parasites, Helicobacter pylori and its virulence factors, opportunistic bacteria, and bacteria that may cause autoimmune reactions. Additionally, the test reveals markers for digestive function, immune responses, estrogen metabolism, and inflammation. As proper gut function is essential to immune function and proper levels of inflammation, this test can provide essential insights into this process.

Food Sensitivity Testing

Food Sensitivity Testing via LRA Food Block 96 by ELISA/ACT Biotechnologies: this test can detect allergens and sensitivities to a variety of substances, including food, additives and preservatives, food colorings, molds, environmental chemicals, toxic minerals and metals, medications, therapeutic herbs, dander, hairs, and feathers. These tests are particularly useful for patients with autoimmune diseases, chronic diseases, immune dysfunction, and food allergies. As immune dysfunction and food sensitivities can contribute to sinusitis, this is a good test if food sensitivity is a potential trigger.

Organic Acid Testing

Nutrient deficiency testing via the Organic Acids Test (OAT) from Mosaic Diagnostics: this test assesses an individual's nutrient levels, including vitamins, minerals, and antioxidants. In addition, this test also measures GI fungal/bacterial overgrowth, oxalate formation, mitochondrial function, neurotransmitter status, and detoxification markers. This test provides insight into how a person's body functions on a metabolic level and gives a good overview of many contributing factors resulting in disease.

Environmental Toxin Testing

Environmental toxin testing via the ENVIROtox Complete Panel by Mosaic Diagnostics: this test offers a thorough examination of a patient's current exposure to toxic chemicals, as well as the associated oxidative stress, inflammation, and mitochondrial damage. This test panel comprehensively analyzes a patient's toxic chemical burden, as exposure to these toxins can impair immune function and contribute to sinusitis.

Adrenal Stress Testing

Cortisol Testing via the Adrenal Stress Profile by ZRT Laboratory: this test measures cortisol levels in the saliva to evaluate adrenal function. This test can help identify imbalances in the stress response system, contributing to various health issues, including immune dysfunction and allergies, leading to sinusitis.

Conventional Treatment for Sinusitis

Conventional treatment for sinusitis may include antibiotics, decongestants, allergy medications, OTC pain relievers, and nasal sprays. In addition, surgery may sometimes be necessary to address structural issues in the sinuses. However, overuse of antibiotics has contributed to the growing problem of antibiotic resistance and should be avoided whenever possible.

Functional Medicine Treatment for Sinusitis

While conventional treatments focus on symptom management through antibiotics and over-the-counter medications, functional medicine takes a different approach. Instead of just treating the symptoms, functional medicine aims to identify and address the root cause of the problem.


For optimal immune function, reduced inflammation, and prevention of infections, such as sinusitis, it is recommended to follow a diet rich in whole, nutrient-dense foods. This includes a variety of colorful fruits and vegetables, whole grains, lean protein sources, healthy fats, and low-fat dairy products. The Mediterranean Diet, in particular, is a great choice to support overall health.

If food sensitivities are suspected, an elimination diet is a dietary approach that can help identify and eliminate specific foods and chemicals that may cause sensitivity. If a certain food is thought to cause symptoms, the elimination diet protocol involves removing suspected foods for a certain period, reintroducing them one at a time, and avoiding any that cause symptoms for a further period before reintroduction. This approach can help determine which foods may be triggering symptoms and guide a patient's nutritional therapy to decrease their body's immune response.

Promoting healthy gut function is also key to treating sinusitis through functional medicine. Eating a diet high in fiber and fermented foods can help support beneficial gut bacteria. Additionally, taking prebiotics and probiotics is recommended to promote optimal gut health. Research has shown that probiotics, which aid in restoring healthy gut bacteria, can effectively prevent and treat sinusitis. Focusing on a nutrient-dense diet and promoting gut health can reduce the risk of infections and support overall wellness.

Complementary and Alternative Medicine

Complementary and alternative medicine can also play a role in treating sinusitis. Some evidence-based treatments include:

Reducing Environmental Factors

To reduce the risk of sinusitis from environmental irritants, it is important to limit exposure to these substances whenever possible. This can include avoiding areas of heavy pollution, quitting smoking, and using protective equipment such as masks or respirators in hazardous work environments.

Referral to Functional Medicine Dentist

Referral to a Functional Medicine Dentist may be warranted to rule out odontogenic sinusitis if symptoms present. Treatment for odontogenic sinusitis typically involves addressing the underlying dental issue in addition to treating the sinus infection itself. This may include procedures such as dental extractions, root canal treatment or removal of infected tissue in the mouth. Prescriptive or natural antibiotics are often prescribed to help fight the infection and reduce inflammation.


Sinusitis is a common condition that affects the sinuses and can be caused by various factors such as allergies, immune system dysfunction, inflammation, and poor gut health. While conventional treatments can provide relief, exploring functional medicine approaches can address the root cause of the problem. Functional medicine labs can help identify the condition's underlying cause and guide personalized treatment options. A nutrient-dense diet, like the Mediterranean Diet, promoting healthy gut function can help reduce the risk of sinusitis and support overall wellness. Complementary and alternative medicine treatments, such as nasal irrigation, steam inhalation, and herbal remedies, can also relieve those suffering from sinusitis.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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