Protocols
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May 12, 2025

Code Blue Protocol: How Hospitals Handle Critical Situations

Medically Reviewed by
Updated On
June 18, 2025

Imagine the tension as a hospital's PA system announces or several pagers alarm a text, “Code Blue, Room 214.” Within seconds, medical staff race down the hallway. But what does “Code Blue” really mean?

Hospitals use color-coded emergency alerts to communicate urgent situations quickly and discreetly. These codes, which vary slightly by region or institution, originated in the 1960s to keep emergency announcements clear and concise. Code Blue is perhaps the most critical.

This article explains Code Blue, its significance, and how healthcare professionals respond to this life-or-death emergency.

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Defining Code Blue

Before diving into protocols and procedures, let's clarify what Code Blue stands for and the types of emergencies it involves.

A Code Blue is a hospital-wide alert signaling that a patient is experiencing cardiac or respiratory arrest and requires immediate resuscitation. It's triggered when a patient stops breathing, loses consciousness due to cardiac arrest, or shows no detectable pulse.

The types of medical emergencies covered in a Code Blue typically consist of:

The Code Blue Response Team

Once a Code Blue is announced, a specially trained medical team springs into action. While team composition can vary by hospital, each member has a clearly defined and critical role.  

Team Composition

All staff responding to a Code Blue must be certified by Advanced Cardiac Life Support (ACLS). A typical Code Blue team includes:

  • Physicians: Usually a hospitalist, emergency room physician, anesthesiologist, or an intensive care doctor.
  • Critical care or rapid response nurses: Trained to act quickly in emergencies.
  • Respiratory therapists: Experts in airway management and ventilator support.
  • Pharmacists: Provide and prepare emergency medications.
  • Advanced practice providers: Such as certified registered nurse anesthetists (CRNAs) or physician assistants (PAs).

Key Roles and Responsibilities

  • Team Leader: The first physician to arrive usually leads the Code Blue, coordinating all medical decisions and directing the team.
  • Compressor: Performs high-quality chest compressions. Because this task is physically demanding, multiple team members may rotate in.
  • Airway Manager: Typically, this is an anesthesiologist or CRNA, responsible for ensuring the airway is open and managing intubation.
  • Medication Nurse or Pharmacist: Prepares and administers emergency drugs like epinephrine or amiodarone.
  • Recorder: Accurately documents all interventions and times, including medication administration and shocks.
  • The patient’s Assigned Nurse or Care Provider: Offers critical background information, such as the patient’s medical history and the events leading up to the emergency.

Essential Equipment 

Most or all of the equipment needed during a code blue is typically available in a crash cart

  • Defibrillator: For rhythm analysis and delivering life-saving shocks.
  • Ambu bag and oxygen: To manually support breathing.
  • Endotracheal tubes and airway adjuncts:  For intubation and securing the airway.
  • IV fluids and emergency medications: Including vasopressors and antiarrhythmics.
  • Suction device: To clear airways of secretions or obstructions.

Code Blue Procedure

From the first call to the final intervention, every step in a Code Blue is carefully coordinated to increase the chance of patient survival.

How a Code Blue is Initiated

Any hospital staff member can initiate a Code Blue by pressing an emergency button or dialing a designated code on the hospital phone system when a patient experiences cardiac or respiratory arrest.

Step-by-Step Response Protocol

  1. Initial Assessment: Confirm absence of pulse or breathing.
  2. Start CPR: Begin high-quality chest compressions immediately.
  3. Call for Help: Alert the Code Blue team.
  4. Secure the Airway: Provide manual ventilation and prepare for intubation.
  5. Attach Defibrillator: Assess the heart rhythm and deliver shocks if needed.
  6. Administer Medications: Give emergency drugs per Advanced Cardiac Life Support (ACLS) guidelines.
  7. Monitor Vital Signs: Continue efforts until the patient regains a pulse (return of spontaneous circulation, or ROSC) or resuscitation efforts are discontinued.

Communication During a Code Blue

Clear, concise, and standardized communication is critical. The team leader directs all actions, ensuring smooth coordination and rapid decision-making. Members are trained to speak in brief, direct phrases to minimize confusion and delay.

After the Code Blue

Although the critical moment may have passed, what happens after Code Blue is just as important for the patient and the care team.

Post-Code Blue Patient Care

Successfully resuscitated patients are typically transferred to the Intensive Care Unit (ICU) for continued care and close monitoring. The focus shifts to stabilization and uncovering the underlying cause of the arrest.

Key components of post-Code Blue care include:

  • Stabilizing vital signs in the ICU
  • Continuing Advanced Cardiac Life Support (ACLS) as needed
  • Performing rapid diagnostic tests (e.g., EKG, CT scan, ultrasound, laboratory tests) to help determine the cause of the event
  • Developing a plan for monitoring, treatment, and recovery

Debriefing and Documentation

Immediately after the event, the care team conducts a structured debriefing to review what went well and what could be improved. Every step taken during the Code Blue (e.g., medications, timing, interventions) is thoroughly documented in the patient's medical record and the hospital's code log.

Analyzing Outcomes for Quality Improvement

Many hospitals use Code Blue data as part of ongoing quality improvement efforts. Events are reviewed by clinical committees to assess performance, update protocols, enhance training, and ensure that equipment and systems function optimally during future emergencies.

Code Blue in Different Hospital Settings

While the core principles of Code Blue remain consistent, the response can vary slightly depending on the hospital's location. Each setting presents unique challenges and resources that influence how quickly and effectively the team can respond.

Emergency Room (ER)

Code Blues in the ER are typically recognized and initiated quickly due to the constant presence of emergency physicians and trauma-trained staff. The ER is equipped with immediate access to advanced diagnostics, resuscitation tools, and critical care support.

Intensive Care Unit (ICU)

Patients are already under continuous monitoring in the ICU, and the care team is trained to respond rapidly to any signs of deterioration. Code Blue responses in this setting are usually immediate and highly specialized.

General Wards (Medical/Surgical Floors)

In general hospital wards, patients may not be monitored continuously, which can lead to delays in recognizing cardiac or respiratory arrest. These areas rely heavily on early warning systems and staff vigilance to detect deterioration and promptly initiate a Code Blue.

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Key Takeaways

  • Code Blue refers to a cardiac or respiratory emergency requiring immediate resuscitation.
  • A specialized team rapidly responds using ACLS protocols, emergency medications, and advanced equipment.
  • Procedures involve quick recognition, coordinated communication, and prompt action.
  • Post-Code Blue care and documentation are critical for patient recovery and institutional learning.
  • The setting (ER vs. ICU vs. general ward) can affect the speed and resources available during a Code Blue.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Cleveland Clinic. (2021, September 24). Intubation: Purpose, Procedure and Potential Risks. Cleveland Clinic. https://my.clevelandclinic.org/health/articles/22160-intubation

Dalal, R., & Grujic, D. (2024). Epinephrine. National Library of Medicine; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482160/

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Prince, C. R., Hines, E. J., Chyou, P.-H. ., & Heegeman, D. J. (2014). Finding the Key to a Better Code: Code Team Restructure to Improve Performance and Outcomes. Clinical Medicine & Research, 12(1-2), 47–57. https://doi.org/10.3121/cmr.2014.1201

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