Medication Fact Sheets
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July 11, 2025

Proper Use of Your Fluticasone and Salmeterol Powder Inhaler

Medically Reviewed by
Updated On
July 11, 2025

Fluticasone propionate and salmeterol inhalation powder is a combination therapy commonly prescribed to manage asthma and chronic obstructive pulmonary disease (COPD). Fluticasone is a corticosteroid that reduces inflammation in the airways, while salmeterol is a long-acting beta-agonist (LABA) that helps relax airway muscles, making breathing easier.

This guide provides step-by-step instructions on correctly using a fluticasone propionate and salmeterol inhaler, ensuring maximum benefit from your medication.

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Understanding Your Fluticasone Propionate and Salmeterol Inhaler

Before diving into the steps for proper inhaler use, it’s important to understand what this medication does and how it works. This background will help you appreciate why each step in the inhaler process is critical for effective treatment.

What is fluticasone propionate and salmeterol?

Fluticasone propionate is a corticosteroid that reduces inflammation in the airways, helping to prevent asthma attacks and control symptoms. Salmeterol, on the other hand, is a long-acting bronchodilator that helps relax airway muscles, providing extended relief from symptoms like shortness of breath and wheezing. When combined, these two medications provide comprehensive respiratory support.

How does the combination work?

Fluticasone and salmeterol work together to target inflammation and airway constriction, making breathing easier over the long term. 

  • Fluticasone decreases inflammation and mucus production, while salmeterol helps keep the airways open for up to 12 hours after each dose. 
  • It is important to note that this inhaler is not used to treat a sudden asthma attack.

Types of inhalers (e.g., Advair Diskus, generic versions)

Fluticasone and salmeterol are available in various forms, including Advair Diskus, AirDuo RespiClick, and their generic versions. These dry powder inhalers are breath-activated, meaning the medication is released when you inhale deeply, making them different from traditional press-and-breathe inhalers.

Preparing Your Inhaler for Use

Now that you understand what your inhaler does, it’s time to prepare it for use. Proper preparation ensures each dose is accurate and effective.

Checking the dose counter

Most fluticasone and salmeterol inhalers have a built-in dose counter. Before each use, check the counter to ensure you have enough medication left. If it shows zero, it's time to replace your inhaler.

Priming a new inhaler (if necessary)

While most powder inhalers do not require priming, it's essential to follow the specific instructions for your device. Some inhalers may require you to load the first dose or perform a test puff to ensure it's ready for use.

Importance of proper storage

To maintain the effectiveness of your inhaler, store it in a cool, dry place away from direct sunlight and moisture. Avoid storing it in high-humidity areas like bathrooms, as this can cause the powder to clump or degrade over time.

Step-by-Step Guide to Using Your Inhaler

Correct inhaler technique is essential for ensuring the medication reaches your lungs effectively. Proper inhaler use can improve your breathing, reduce the frequency of asthma or COPD flare-ups, and enhance your overall quality of life. Use the inhaler as directed by your healthcare provider. Do not use it more often than prescribed. 

Here's a detailed, step-by-step guide to help you get the most out of your fluticasone and salmeterol inhaler.

Opening the Device

  1. Hold the inhaler correctly: Always hold your inhaler upright or horizontally, depending on the specific device you use (e.g., Advair Diskus). This ensures the powder remains settled and ready for use.
  2. Open the inhaler: Follow the manufacturer’s instructions to open the inhaler. This often involves sliding a lever, twisting a mouthpiece, or pressing a button to load the next dose.
  3. Check the dose counter: Confirm that there are doses remaining before use. If the counter shows zero, the inhaler is empty and should be replaced.

Loading the Dose

  1. Activate the dose: Depending on the inhaler model, this may involve sliding a lever (like on the Advair Diskus) or twisting the mouthpiece to the correct position.
  2. Avoid shaking: Unlike metered-dose inhalers (MDIs), dry powder inhalers like fluticasone and salmeterol devices should not be shaken, as this can dislodge the powder and reduce the accuracy of your dose.
  3. Inspect the mouthpiece: Make sure the mouthpiece is clean and free of debris before use to avoid inhaling any unwanted particles.

Proper Inhalation Technique

  1. Exhale fully: Stand or sit up straight and exhale fully, away from the inhaler, to empty your lungs. This creates more room for the medication to reach deep into your airways.
  2. Position the mouthpiece: Place the mouthpiece in your mouth, creating a tight seal with your lips to prevent any medication from escaping.
  3. Inhale deeply and quickly: Take a strong, deep breath in through your mouth, not your nose. This quick inhalation is necessary to draw the dry powder medication deep into your lungs.
  4. Hold your breath: After inhaling, hold your breath for about 10 seconds, or as long as you comfortably can, to allow the medication to settle in your airways.
  5. Exhale slowly: Remove the inhaler from your mouth and exhale gently, away from the inhaler, to avoid blowing moisture into the device.

Holding Your Breath and Closing the Device

  1. Hold for optimal absorption: Holding your breath for about 10 seconds allows the medication to penetrate deeply into your lungs, maximizing its therapeutic effects.
  2. Close the inhaler: After use, close the device according to the manufacturer’s instructions to protect the remaining doses from moisture and contamination.
  3. Rinse your mouth: To reduce the risk of oral thrush (a fungal infection that can occur with inhaled corticosteroids), rinse your mouth with water and spit it out after each use. This step is crucial for preventing side effects.

Final Check and Safe Storage

  1. Store your inhaler properly: Keep your inhaler in a cool, dry place, away from direct sunlight and moisture. This helps preserve the potency of the medication.
  2. Track your doses: Regularly monitor the dose counter to ensure you don’t run out unexpectedly.
  3. Know when to replace: Replace the inhaler when the dose counter reaches zero or when it expires, even if you think there is still medication left.

Common Mistakes and How to Avoid Them

Even experienced inhaler users can make mistakes that reduce the effectiveness of their medication. Understanding these common errors can help you avoid them and improve your respiratory health.

  • Incorrect inhaler position: Holding the inhaler at the wrong angle can prevent the full dose from reaching your lungs. Always hold the inhaler upright during use.
  • Poor breath coordination: Breath-activated inhalers require a quick, deep breath for adequate dosing. If you struggle with this, practice breathing exercises or consider using a spacer if recommended by your healthcare provider.
  • Not holding your breath after inhalation: Failing to hold your breath for 10 seconds can reduce the amount of medication absorbed into your lungs. Make this a consistent part of your inhaler routine.
  • Forgetting to rinse your mouth after use: Fluticasone can increase the risk of oral thrush if not properly rinsed out of your mouth. Rinse your mouth and spit out the water after each use to minimize this risk.

Maintenance and Cleaning

Keeping your inhaler clean and properly maintained is essential for accurate dosing and preventing respiratory infections.

  • Regular cleaning of the mouthpiece: Wipe the mouthpiece with a slightly damp or dry cloth at least once a week to remove any powder residue. Avoid using water, as moisture can clog the inhaler mechanism.
  • When to replace your inhaler: Replace your inhaler when the dose counter reaches zero, even if you feel there is still powder left. This ensures you are receiving the correct dose with each inhalation.
  • Proper disposal of empty inhalers: Follow local regulations for inhaler disposal. While most inhalers can be discarded in regular household trash, some areas may have specific recycling programs for medical devices.

Frequently Asked Questions (FAQs)

Q: How often should I use my fluticasone propionate and salmeterol inhaler?
A:  Fluticasone propionate and salmeterol inhalers are typically used twice daily, approximately 12 hours apart, as directed by your healthcare provider. This medication is intended for long-term control of asthma and COPD symptoms and should be used consistently for the best results. Do not use this inhaler more frequently than prescribed, as it contains a long-acting beta-agonist (LABA) that can increase the risk of serious asthma-related complications if overused.

Q: Can I use this inhaler for immediate relief during an asthma attack?
A:
No, this inhaler is not intended for immediate relief during an asthma attack or sudden breathing problems. It is a maintenance medication designed to reduce inflammation and improve long-term lung function. For sudden symptoms, use a short-acting rescue inhaler, such as albuterol or levalbuterol, as directed by your healthcare provider. If you experience worsening symptoms or frequent asthma attacks, seek medical advice promptly.

Q: What are the potential side effects of fluticasone propionate and salmeterol?
Common side effects may include:

  • Throat irritation or hoarseness
  • Headache
  • Cough
  • Upper respiratory tract infections
  • Muscle pain

More serious but less common side effects include:

  • Increased heart rate or palpitations
  • Shakiness or tremors
  • Oral thrush (fungal infection)
  • Pneumonia (in patients with COPD)
  • Adrenal insufficiency

If you experience severe side effects, such as difficulty breathing, chest pain, or signs of an allergic reaction (e.g., swelling of the face, tongue, or throat), seek emergency medical attention immediately. Always discuss potential side effects with your healthcare provider before starting this medication.

Q: How do I know when my inhaler is empty?
A:
Most fluticasone propionate and salmeterol inhalers come with a built-in dose counter that shows the number of remaining doses. Once the counter reaches zero, the inhaler is empty and should be replaced, even if it still feels like there is powder inside. Continuing to use an empty inhaler can result in inadequate dosing and reduced symptom control.

Q: Can I use my inhaler with a spacer device?
A:
Most fluticasone propionate and salmeterol inhalers are dry powder inhalers (e.g., Advair Diskus) that are not typically used with spacer devices, as they rely on a quick, deep breath to deliver the medication. However, if you have difficulty using your inhaler correctly, talk to your healthcare provider about options, as some inhalers may be available in a metered-dose format that can be used with a spacer.

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Key Takeaways

  • Consistent Use is Critical: Use your inhaler as prescribed, typically twice daily, to maintain long-term control of asthma or COPD symptoms.
  • Not for Immediate Relief: This inhaler is not intended for sudden asthma attacks – always keep a rescue inhaler, like albuterol, on hand for emergencies.
  • Proper Technique Matters: Effective inhalation involves a quick, deep breath to ensure the dry powder reaches your lungs. Exhale fully before use and hold your breath for about 10 seconds afterward to maximize absorption.
  • Monitor Your Dose Counter: Always check the dose counter before use. Once it reaches zero, replace the inhaler to ensure you are receiving accurate dosing.
  • Avoid Common Mistakes: Do not shake your dry powder inhaler, and always rinse your mouth after each use to reduce the risk of oral thrush.
  • Store Properly: To preserve the medication's effectiveness, keep your inhaler in a cool, dry place away from direct sunlight and moisture.
  • Maintenance is Essential: Clean the mouthpiece regularly with a dry cloth and follow proper disposal guidelines when your inhaler is empty.
  • Seek Professional Guidance: If you have trouble using your inhaler correctly or are experiencing frequent flare-ups, consult your healthcare provider for personalized advice.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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