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How is Acne Diagnosed?

Why This Was Updated?

Our specialists regularly review advancements in health and wellness, ensuring our articles are updated with the newest information as it becomes accessible.
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Acne is one of the most common skin conditions, affecting millions of people worldwide, from teenagers to adults. It affects up to 90% of adolescents, and acne in adult women is increasing. The severity can range from mild, occasional breakouts to persistent, painful cystic acne.Β 

Receiving the proper treatment begins with an accurate diagnosis: understanding the type and underlying causes of a person’s acne leads to more personalized care.Β 

Diagnosing acne is not just about visible lesions; a dermatologist can perform a comprehensive medical evaluation to identify clues to underlying hormonal imbalances, genetic or lifestyle factors.Β 

While dealing with acne can feel frustrating, overwhelming, or worse, there is hope. This article will guide you through how healthcare providers diagnose acne and tailor treatment options to each individual’s unique needs.

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Why Accurate Diagnosis is Important

Effective treatment starts with the right diagnosis: different types of acne (blackheads, whiteheads, cysts, hormonal) have different causes and may require distinct treatments. Misdiagnosis can worsen the condition.Β 

Additionally, conditions like rosacea or folliculitis can mimic acne, making correct identification essential for effective therapy. Early diagnosis helps prevent scarring and long-term damage, leading to clearer skin and better overall health.

The Clinical Evaluation Process

Acne evaluation begins with understanding your medical history.

Patient History

A thorough medical history helps dermatologists assess factors such as:

  • Onset of Acne: understanding when the condition began is crucial for tracking its progression and identifying patterns, like adolescent vs adult-onset acne.
  • Previous Treatments: knowing what treatments you’ve already tried, both successful and unsuccessful, helps guide current treatment decisions. Tell your dermatologist about over-the-counter and natural treatments as well as prescriptions.Β 
  • Family History and Hormonal Changes: dermatologists often look for a genetic predisposition to acne as well as hormonal fluctuations or patterns (e.g., during puberty, menstruation, or pregnancy) that might aggravate symptoms.
  • Lifestyle Factors: Diet, stress, and skincare habits are also reviewed, which can all impact the severity and persistence of acne.

Physical Examination

The physical exam will evaluate:

  • Acne Type and Severity: dermatologists visually assess the types of lesions present to identify blackheads, whiteheads, papules, pustules, or cysts. This information is essential to classify acne as mild, moderate, or severe, as part of the diagnosis.
  • Acne Distribution: the location of acne (face, chest, or back) helps determine its pattern and possible causes. For example, jawline acne may suggest hormonal triggers, while back acne may be linked to lifestyle factors like exercise in tight clothing.
  • Differentiating Acne from Other Conditions: the exam helps distinguish acne from similar-looking conditions such as rosacea, folliculitis, or perioral dermatitis, which have different causes and treatment approaches.

Classification and Severity Grading

A dermatologist will assess the type and severity of acne, which will guide treatment decisions.

Types of Acne

Acne falls into two categories: non-inflammatory and inflammatory. Identifying the type of acne will determine treatment.Β 

Non-inflammatory acne includes blackheads and whiteheads, caused by clogged pores.Β 

Inflammatory acne includes papules, pustules, nodules, and cysts, which are deeper lesions that can scar.Β 

Non-inflammatory acne may respond to over-the-counter treatments like salicylic acid or benzoyl peroxide, while inflammatory acne often requires stronger prescription options such as antibiotics, retinoids, or isotretinoin.

Acne Severity Grading

There are several scales used to grade acne severity in clinical and research settings. Generally, acne severity is classified into three levels: mild, moderate, and severe.Β 

This grading is based on the number and type of lesionsβ€”such as comedones, papules, pustules, nodules, and cystsβ€”as well as the areas affected (face, chest, back).

  • Mild Acne: few comedones and papules, with minimal or no pustules, usually affecting small areas.
  • Moderate Acne: more comedones, papules, and pustules, often affecting larger areas like the face, chest, and back.
  • Severe Acne: numerous pustules, nodules, and cysts with a high risk of scarring, often causing discomfort.

Treatment options depend on severity, with mild cases often managed by over-the-counter products and moderate to severe cases requiring prescription medications.

Differential Diagnosis: Ruling Out Other Skin Conditions

A dermatologist will determine if your acne is due to, or complicated by, other conditions.Β 

Common Conditions That Mimic Acne

Several skin conditions resemble acne, but often require different treatments.Β 

Rosacea

Rosacea causes persistent redness, papules, pustules, and visible nets of blood vessels (telangiectasia), mostly on the central face. Unlike acne, rosacea lacks comedones (blackheads and whiteheads).Β 

Rosacea flares are triggered by environmental factors such as UV exposure, extreme temperatures, spicy foods, and alcohol. It often involves eye irritation (ocular rosacea) and presents with chronic redness, unlike acne, which is influenced by hormonal changes and clogged pores.

Perioral Dermatitis

Perioral dermatitis presents as small inflammatory papules, pustules, or scaly patches around the mouth, nose, and eyes, but without comedones. It is triggered by topical steroid use, cosmetics, fluorinated toothpaste, and environmental factors.Β 

Perioral dermatitis differs from acne by its location and lack of blackheads. Treatment often involves stopping steroid use and applying topical or oral antibiotics.

Folliculitis

Folliculitis occurs when hair follicles become inflamed or infected, leading to red or pus-filled bumps. It can be caused by bacteria, fungi, viruses, or irritation from shaving. Unlike acne, folliculitis is related to hair follicles and lacks comedones.Β 

It can appear anywhere on the body where hair grows, while acne is more common on the face, chest, and back. Severe cases may require topical or oral antibiotics or antifungals.

Milia

Milia are tiny, white keratin-filled cysts that form just under the skin. Unlike acne, which involves clogged pores, milia are firm, white cysts that do not become red or inflamed. They do not cause scarring unless manipulated.

Hidradenitis Suppurativa (HS)

Hidradenitis suppurativa is a chronic condition that causes painful nodules, abscesses, and scarring, typically in skin folds like the armpits, groin and buttocks, and under the breasts. Unlike acne, HS forms deep abscesses and tunnels, leading to more severe scarring. It requires more intensive treatment, including medical and surgical interventions.

By differentiating these conditions from acne, dermatologists can provide more targeted, effective treatments, improving outcomes and preventing overtreatment.

The Role of Skin Type

A patient’s skin type significantly influences both diagnosis and treatment of acne and acne-mimicking conditions. Clinicians should take skin type into consideration when developing personalized treatment plans.

Oily Skin

People with oily skin are more prone to clogged pores and excess sebum production, often leading to more severe acne and scarring.

Oily skin results from increased sebum production, which can clog hair follicles and lead to acne formation. Sebum, composed of lipids like squalene, can contribute to an environment conducive to bacterial growth, especially Propionibacterium acnes (P. acnes), which triggers inflammation in the skin.Β 

This process often leads to both inflammatory and non-inflammatory acne lesions, such as blackheads, whiteheads, and pimples.

In oily skin, acne often presents with larger numbers of comedones and pustules. However, conditions like seborrheic dermatitis or malassezia (fungal) folliculitis can be mistaken for acne and require antifungal treatments rather than traditional acne medications.

Oily skin benefits from ingredients like salicylic acid, benzoyl peroxide, and retinoids that help control oil and reduce pore blockages.

Combination Skin

Combination skin involves areas of both oily and dry skin, making diagnosis and treatment challenging.

Acne and other skin conditions can behave differently in combination skin. Sebum production plays a key role in acne, particularly in oily areas like the T-zone, while dry areas may experience conditions like perioral dermatitis. This imbalance presents challenges, with acne affecting oilier regions and dryness contributing to other skin issues.

A balanced approach is needed, often combining non-comedogenic moisturizers with acne treatments like topical retinoids or antibiotics.

Sensitive Skin

Sensitive skin can react adversely to common acne treatments and is more prone to irritation and dermatitis. Acne-like eruptions can occur due to reactions to skincare products or environmental factors.

Eczema, allergic contact dermatitis, or rosacea should be considered in individuals with sensitive skin, as these conditions can mimic or exacerbate acne. Clinicians should review patients’ skincare routines and identify potential irritants or allergens.

For sensitive skin, gentler treatments like azelaic acid or niacinamide may be preferred, and harsh, stripping products should be avoided to prevent further irritation.

Laboratory Tests and Hormonal Evaluations

Blood and hormonal testing may be warranted in certain cases:

When Blood Tests Are Recommended

Blood tests are typically recommended when hormonal imbalances are suspected, particularly in cases of adult acne that don’t respond to conventional treatments. These tests are essential when acne presents alongside signs of polycystic ovary syndrome (PCOS), such as irregular menstrual cycles or excess facial/body hair.Β 

These tests typically measure levels of androgens, including testosterone and dehydroepiandrosterone sulfate (DHEA-S), as well as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These tests are typically performed during the follicular phase of the menstrual cycle.Β 

Insulin resistance markers should also be tested, as both androgen excess and insulin dysregulation are key factors contributing to acne in cases of hormonal imbalance.Β 

Hormonal Acne Diagnosis in Women

Dermatologists assess hormonal factors in women by reviewing menstrual history, checking for signs of hyperandrogenism (e.g., hirsutism, oily skin), and considering related symptoms like weight gain or irregular periods.Β 

Hormonal acne often flares during times of major hormone shifts including puberty, certain phases of the menstrual cycle (particularly in the premenstrual period), pregnancy, and perimenopause. It commonly appears around the mouth or along the jawline. Diagnosing conditions like PCOS or identifying hormone imbalances is necessary since these conditions can manifest with acne.Β 

Advanced Diagnostic Techniques

The following diagnostic techniques may be utilized by practitioners:

Skin Biopsies

Skin biopsy is typically not required for the diagnosis of acne vulgaris, as the condition is usually diagnosed based on physical examination. Biopsies are generally unnecessary unless there are atypical presentations or a need to rule out other conditions that mimic acne, such as seborrheic dermatitis or bacterial folliculitis.Β 

Microbiome Analysis and Genetic Testing (Emerging Areas)

These new testing strategies are still being understood but appear to be promising:

Microbiome Analysis

Gut and skin health are intimately related. Stool microbiome testing offers valuable insights for treating acne, especially when acne is linked to dysbiosis. Key reasons include:

  • Gut-Skin Axis: the gut microbiome and skin microbiome are interconnected through the gut-skin axis, where imbalances in gut bacteria can influence skin inflammation, immune response, and overall skin health, contributing to conditions like acne.
  • Inflammation: gut dysbiosis can cause chronic inflammation, worsening acne. Testing helps target treatments to reduce inflammation.
  • Hormonal Balance: gut bacteria influence hormones like estrogen, and imbalances can affect acne. Testing identifies these disruptions.

Genetic Testing

The capabilities and usefulness of genetic testing is exploding. To better understand genetic causes of acne, genetic testing looks at specific genes associated with inflammation, sebum production, and skin barrier function. It can also identify specific genetic variations that can influence DNA methylation, which may play a key role in the development of severe acne.

When to Seek Professional Help

If breakouts persist, lead to scarring, or don’t improve with over-the-counter treatments, it’s time to see a dermatologist. Early intervention can prevent long-term damage, and dermatologists can develop personalized treatment plans.

What to Expect After Diagnosis

Following proper diagnosis, treatment may include topical or oral medications and lifestyle changes. Also expect follow-up appointments. Managing acne requires ongoing care, with regular adjustments to the treatment plan to ensure lasting results.

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Key Takeaways

  • Effective acne management starts with the right diagnosis: different acne types (blackheads, cysts, etc.) may require different treatment approaches. A thorough evaluation helps differentiate acne from similar skin conditions like rosacea or folliculitis.
  • If acne persists or worsens despite over-the-counter treatments, it's time to see a dermatologist. Early intervention can prevent scarring and more severe complications, offering the chance for a tailored and more effective treatment plan.
  • With the right diagnosis, dermatologists can develop personalized treatment plans combining medications, lifestyle changes, and regular monitoring. Acne can be effectively controlled and minimized, improving both skin health and confidence.
The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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American Academy of Dermatology Association. (2019). Skin conditions by the numbers. Aad.org. https://www.aad.org/media/stats-numbers

Awaloei, Y. M., Prastowo, N. A., & Regina, R. (2021). The correlation between skin type and acne scar severity in young adults. Jurnal Kedokteran Dan Kesehatan Indonesia, 12(1), 52–57. https://doi.org/10.20885/jkki.vol12.iss1.art9

Bagatin, E., Freitas, T. H. P., Rivitti-Machado, M. C., Machado, M. C. R., Ribeiro, B. M., Nunes, S., & Rocha, M. A. D. D. (2019). Adult female acne: a guide to clinical practice. Anais brasileiros de dermatologia, 94(1), 62–75. https://doi.org/10.1590/abd1806-4841.20198203

Ballard K, Shuman VL. Hidradenitis Suppurativa. [Updated 2024 May 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534867/

Bataille, V., Snieder, H., MacGregor, A. J., Sasieni, P., & Spector, T. D. (2002). The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. The Journal of investigative dermatology, 119(6), 1317–1322. https://doi.org/10.1046/j.1523-1747.2002.19621.x

Chiu, A., Chon, S. Y., & Kimball, A. B. (2003). The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress. Archives of dermatology, 139(7), 897–900. https://doi.org/10.1001/archderm.139.7.897

Christie, J. (2024, April 1). A Root Cause Medicine Protocol for PCOS. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-pcosΒ 

De Pessemier, B., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021). Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms, 9(2). Retrieved from https://www.mdpi.com/2076-2607/9/2/353.Β 

DeCesaris, L. 3 Simple Lifestyle Changes That Helped Ashley Bring Her Acne Under Control. (2022, March 18). Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-acne

DeCesaris, L. (2022, June 6). What Is Gut Dysbiosis? 7 Signs To Watch For. Rupa Health. https://www.rupahealth.com/post/how-your-gut-bacteria-affects-your-overall-healthΒ 

DePorto T. Understanding acne and how to treat it naturally. Rupa Health. Published September 13, 2022. https://www.rupahealth.com/post/understanding-acne-and-how-to-treat-it-naturallyΒ 

Dessinioti, C., & Katsambas, A. (2024). The Microbiome and Acne: Perspectives for Treatment. Dermatology and Therapy. https://doi.org/10.1007/s13555-023-01079-8

Easthope, A. Possible Root Causes Of Rosacea And How To Treat Them Naturally. (2022, April 1). Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-rosaceaΒ 

β€ŒFarshchian M, Daveluy S. Rosacea. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557574/

Follicle-Stimulating Hormone. (n.d.). Rupa Health. https://www.rupahealth.com/biomarkers/fshΒ 

Gallardo Avila PP, Mendez MD. Milia. [Updated 2023 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560481/

He, S., Li, H., Yu, Z., Zhang, F., Liang, S., Liu, H., Chen, H., & LΓΌ, M. (2021). The Gut Microbiome and Sex Hormone-Related Diseases. Frontiers in microbiology, 12, 711137. https://doi.org/10.3389/fmicb.2021.711137

Heng, A. H. S., Say, Y.-H., Sio, Y. Y., Ng, Y. T., & Chew, F. T. (2021). Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis. BMC Medical Genomics, 14(1). https://doi.org/10.1186/s12920-021-00953-8

Khan, M. J., Ullah, A., & Basit, S. (2019). Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives. The application of clinical genetics, 12, 249–260. https://doi.org/10.2147/TACG.S200341

Luteinizing Hormone. (n.d.). Rupa Health. https://www.rupahealth.com/biomarkers/lhΒ 

Mohiuddin, A. (2019). A Comprehensive Review of Acne Vulgaris. Journal of Clinical Research in Dermatology, 6(2), 1–34. https://doi.org/10.15226/2378-1726/6/2/00186

Perry, M.G. Acne Around The Mouth: Root Causes, Lab Testing, & Fixing Perioral Acne. (2024, July 15). Rupa Health. https://www.rupahealth.com/post/acne-around-the-mouthΒ 

Reynolds, R. V., Yeung, H., Cheng, C. E., Cook-Bolden, F., Desai, S. R., Druby, K., Freeman, E. E., Keri, J. E., Stein, L. F., Jerry K.L. Tan, Tollefson, M. M., Weiss, J. S., Wu, P. A., Zaenglein, A. L., Jung Min Han, & Barbieri, J. S. (2024). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 90(5). https://doi.org/10.1016/j.jaad.2023.12.017

Rubenstein, R. M., & Malerich, S. A. (2014). Malassezia (pityrosporum) folliculitis. The Journal of clinical and aesthetic dermatology, 7(3), 37–41.

Stanford, J. Hormonal Acne: Causes, Treatments, and Prevention Strategies. (2024, June 20). Rupa Health. https://www.rupahealth.com/post/hormonal-acneΒ 

Sutaria AH, Masood S, Saleh HM, et al. Acne Vulgaris. [Updated 2023 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459173/

Teeter, L. 4 Lab Test That Can Help You Explore the Connection Between Inflammation and Your Patients Metabolic Health. (2023, May 18). Rupa Health. https://www.rupahealth.com/post/the-connection-between-inflammation-metabolic-health

TITUS, S., & HODGE, J. (2012). Diagnosis and Treatment of Acne. American Family Physician, 86(8), 734–740. https://www.aafp.org/pubs/afp/issues/2012/1015/p734.html/1000

Tolaymat L, Hall MR. Perioral Dermatitis. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK525968/

Vasquez, K. (2022, August 22). How Gut Dysbiosis Negatively Affects Hormone Regulation, Immune System Activation, and Neurotransmitter Production. Rupa Health. https://www.rupahealth.com/post/how-gut-dysbiosis-negatively-affects-hormone-regulation-immune-system-activation-and-neurotransmitter-productionΒ 

Weinberg, J. (2022, March 31). How to tell if you have an estrogen imbalance. Www.rupahealth.com. https://www.rupahealth.com/post/a-functional-medicine-approach-to-estrogen-imbalanceΒ 

Weinberg, J. Integrative Dermatology Approach to Rosacea. (2023, September 20). Rupa Health. https://www.rupahealth.com/post/integrative-dermatology-approach-to-rosaceaΒ 

Woo, Y. R., & Kim, H. S. (2022). Truncal Acne: An Overview. Journal of Clinical Medicine, 11(13), 3660. https://doi.org/10.3390/jcm11133660

Wu, Y., Chen, Y., Chen, B., Wu, W., & Yang, J. (2023). DNA methylation mediated genetic risk in severe acne in a young men population. Frontiers in medicine, 10, 1196149. https://doi.org/10.3389/fmed.2023.1196149

Yoshimura, H. The Role of Environmental Toxins in Skin Health: What Practitioners Need to Know. (2024, February 5). Rupa Health. https://www.rupahealth.com/post/the-role-of-environmental-toxins-in-skin-health-what-practitioners-need-to-knowΒ 

β€ŒZhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023). Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review. Biomedicine & Pharmacotherapy, 164, 114985. https://doi.org/10.1016/j.biopha.2023.114985

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