Research Studies
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June 20, 2024

NSAIDs Fact Sheet: Uses, Benefits, Risks, and More

Medically Reviewed by
Updated On
September 17, 2024

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used anti-inflammatory medications available in over-the-counter and prescription formulations. Their mechanism of action provides them with a broad range of uses and applications.Β 

Within this comprehensive fact sheet on NSAIDs, you will find all the information you need for in-depth understanding of NSAIDs to make informed decisions about their usage, safety, and alternatives.

[signup]

What are NSAIDs?

NSAIDs are a class of medications primarily used to improve fever, relieve pain, and reduce inflammation.Β 

NSAIDs work by inhibiting enzymes called cyclooxygenases (COX), either COX-1, COX-2, or both COX enzymes. COX enzymes produce prostaglandins, which are lipid compounds that promote inflammation, pain, and fever in response to an injury or illness. By blocking COX enzymes, NSAIDs decrease the production of prostaglandins, reducing the inflammatory response and relieving associated symptoms.

There are many common types of NSAIDs:

  • Diclofenac
  • Ibuprofen
  • Naproxen
  • Indomethacin
  • Aspirin
  • CelecoxibΒ 

Ibuprofen, naproxen, and indomethacin are non-selective NSAIDs that inhibit both COX-1 and COX-2, making them generally effective against most pain, inflammation, and fever.Β 

In addition to COX inhibition, aspirin also has antiplatelet effects, which may reduce the risk of clotting. Celecoxib is a selective inhibitor of COX-2. It offers comparable effects as the other NSAIDs but may come with a lower risk of gastrointestinal bleeding. The other NSAIDs have their own unique characteristics and considerations for use.

Uses of NSAIDs

Common Uses:Β 

NSAIDs have a number of common uses:

Less Common Uses:Β 

Of the NSAIDs, aspirin offers unique treatment uses. Aspirin is sometimes used in the primary prevention of cardiovascular disease, although this indication is widely debated. Long-term aspirin use (beyond 5 years) has also been shown to reduce the incidence and mortality of many types of cancers.Β 

Additional research is needed to determine the optimal dose of treatment and the risk/benefit analyses before promoting it as a universal chemoprotective agent.

Benefits of NSAIDs

NSAIDs are effective in managing many types of pain, including postoperative pain, menstrual cramps, chronic joint and muscle pain, and pain associated with injury. Their anti-inflammatory effects provide substantial benefits postoperatively, promoting faster recovery.Β 

Following an injury, NSAIDs have been proposed to provide a faster return to function, although the evidence is mixed. In menstrual cramps and dysmenorrhea, NSAIDs inhibit the release of prostaglandins, which are responsible for uterine contractions and associated discomfort.Β 

Chronic joint and muscle pain is best treated with NSAIDs, which can reduce swelling and inflammation and offer promising long-term relief. In rheumatoid arthritis and osteoarthritis, inflammation within the joints mediates significant pain, and NSAIDs have the best documented pain control for pain caused by inflammation.

Risks and Side Effects

Common Side Effects:Β 

Common less serious side effects of NSAIDs include:

  • Gastrointestinal effects: NSAIDs can irritate the lining of the stomach, causing nausea, heartburn, or abdominal pain.
  • Elevated blood pressure: Long-term use of NSAIDs can increase blood pressure, most often in patients with existing hypertension
  • Increased bleeding risk: NSAIDs can potentiate bleeding risk, which can range from mild to severe
  • Allergic reactions: NSAIDs can cause allergic reactions, which most often manifest as skin rashes and irritation

Serious Risks:Β 

More serious risks associated with NSAID use include:

  • Gastrointestinal ulcers Can result from mucosal irritation, potentially causing severe gastrointestinal bleeding
  • Adverse cardiovascular events: Increased risk of heart attack or stroke may result from high NSAID doses or from long-term use
  • Anaphylactic allergic reactions: Rare but potentially adverse effects of NSAID use
  • Acute kidney failure - NSAIDs can affect kidney function, potentially leading to severe, permanent kidney damage

At-Risk Populations:

Certain conditions predispose to a higher risk of adverse effects from NSAID use.

  • Older patients are at heightened risk due to age-related declines in organ function and increased tissue susceptibility.Β 
  • Patients with a known history of gastrointestinal diseases, especially ulcers or gastritis, are more likely to experience NSAID-induced stomach irritation or bleeding.
  • Patients with underlying heart conditions, such as heart disease or hypertension, have a higher risk of cardiovascular complications associated with long-term NSAID use.
  • Those with kidney dysfunction are at significant risk of worsened kidney disease, so NSAIDs should only rarely be used in these cases.
  • The use of multiple medications, such as anticoagulants, corticosteroids, or supplements, along with NSAIDs, is more likely to experience adverse effects, so NSAIDs are contraindicated in patients who are on anticoagulation.

Guidelines for Safe Use of NSAIDs

Dosage and Administration:Β 

When taking NSAIDs, it is necessary to follow the recommended dosage from your healthcare provider or as indicated on the medication label. Do not exceed the recommended dose or take them for longer than prescribed, as this will increase the risk of adverse effects.Β 

NSAIDs should always be taken with food to reduce the risk of gastrointestinal side effects. Be sure to discuss other medications you are taking, and avoid smoking or heavy alcohol use while taking NSAIDs, as this can cause severe side effects.Β 

If any adverse effects occur while taking them, stop the NSAID and discuss your concerns with your healthcare provider. Different medications affect patients differently, so NSAIDs should be part of a personalized treatment plan for the best outcomes.

Duration of Use:Β 

Just as it is necessary to stick to the recommended dosage of NSAIDs, it is also vital to take them only for the duration they are prescribed to reduce potential severe side effects.Β 

  • Short-term use of NSAIDs for temporary conditions is generally safer and is associated with fewer adverse effects.Β 
  • Prolonged NSAID use increases the risk of gastrointestinal complications, kidney damage, and adverse cardiovascular events. In patients who need to take NSAIDs long-term, regular monitoring is essential to ensure their safety.

Interactions with Other Medications:Β 

NSAIDs are known to interact with other medications, especially anticoagulant medications and corticosteroids.Β 

  • Combining NSAIDs with anticoagulants can significantly increase the risk of bleeding, so taking them together is not advised.Β 
  • Combining NSAIDs and corticosteroids increases the risk of gastrointestinal irritation, potentially causing ulcers and bleeding.
  • NSAIDs may necessitate higher doses of antihypertensive medications for optimal blood pressure control.Β 

Many supplements can also increase bleeding risk, especially in combination with NSAIDs:

  • Ginkgo biloba
  • Ginseng
  • Curcumin and turmeric
  • Salicylates
  • Milk thistle
  • St. John’s wort

However, combining nonselective NSAIDs with curcumin derivatives, which inhibit COX-2, has been shown to provide better pain relief without a significant increase in gastrointestinal side effects. Additional research is necessary to determine if curcumin compounds may decrease the doses of NSAIDs required to deliver adequate pain relief.Β 

Alternatives to NSAIDs

Alternative pharmacologic agents to treat pain and inflammation are acetaminophen and corticosteroids.Β 

  • Acetaminophen does not have anti-inflammatory effects but can provide mild to moderate pain relief with a degree of adverse gastrointestinal effects.
  • Corticosteroids are potent anti-inflammatory agents and can be effective for many inflammatory-mediated conditions. However, corticosteroids can cause gastrointestinal bleeding, elevated blood sugar, weight gain, and adrenal dysfunction.

There are many non-pharmacological options to treat pain, which can be used independently or in combination with medications:

[signup]

Key Takeaways

  • NSAIDs have a wide variety of uses, most commonly to improve fever, relieve pain, and reduce inflammation.Β 
  • Their anti-inflammatory properties make them applicable to many medical conditions.
  • However, they are not without risk and should be used only for the recommended duration and in the prescribed dosage to minimize occurrences of adverse effects.
  • Applying other complementary treatments with the use of NSAIDs can enhance their efficacy without increasing associated side effects.
  • Following a personalized plan for each patient can help promote safety and optimal health outcomes.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used anti-inflammatory medications available in over-the-counter and prescription formulations. Their mechanism of action provides them with a broad range of uses and applications.Β 

Within this comprehensive fact sheet on NSAIDs, you will find information to help you understand NSAIDs better and make informed decisions about their usage, safety, and alternatives.

[signup]

What are NSAIDs?

NSAIDs are a class of medications primarily used to help manage fever, relieve pain, and reduce inflammation.Β 

NSAIDs work by inhibiting enzymes called cyclooxygenases (COX), either COX-1, COX-2, or both COX enzymes. COX enzymes produce prostaglandins, which are lipid compounds that promote inflammation, pain, and fever in response to an injury or illness. By blocking COX enzymes, NSAIDs decrease the production of prostaglandins, which may help reduce the inflammatory response and relieve associated symptoms.

There are many common types of NSAIDs:

  • Diclofenac
  • Ibuprofen
  • Naproxen
  • Indomethacin
  • Aspirin
  • CelecoxibΒ 

Ibuprofen, naproxen, and indomethacin are non-selective NSAIDs that inhibit both COX-1 and COX-2, making them generally effective against most pain, inflammation, and fever.Β 

In addition to COX inhibition, aspirin also has antiplatelet effects, which may help reduce the risk of clotting. Celecoxib is a selective inhibitor of COX-2. It offers comparable effects as the other NSAIDs but may come with a lower risk of gastrointestinal bleeding. The other NSAIDs have their own unique characteristics and considerations for use.

Uses of NSAIDs

Common Uses:Β 

NSAIDs have a number of common uses:

Less Common Uses:Β 

Of the NSAIDs, aspirin offers unique uses. Aspirin is sometimes used in the primary prevention of cardiovascular events, although this indication is widely debated. Long-term aspirin use (beyond 5 years) has also been studied for its potential to reduce the incidence and mortality of certain types of cancers.Β 

Additional research is needed to determine the optimal dose of treatment and the risk/benefit analyses before promoting it as a universal chemoprotective agent.

Benefits of NSAIDs

NSAIDs are effective in managing many types of pain, including postoperative pain, menstrual cramps, chronic joint and muscle pain, and pain associated with injury. Their anti-inflammatory effects may provide benefits postoperatively, potentially supporting faster recovery.Β 

Following an injury, NSAIDs have been proposed to provide a faster return to function, although the evidence is mixed. In menstrual cramps and dysmenorrhea, NSAIDs inhibit the release of prostaglandins, which are responsible for uterine contractions and associated discomfort.Β 

Chronic joint and muscle pain may be managed with NSAIDs, which can help reduce swelling and inflammation and offer promising long-term relief. In rheumatoid arthritis and osteoarthritis, inflammation within the joints mediates significant pain, and NSAIDs have the best documented pain control for pain caused by inflammation.

Risks and Side Effects

Common Side Effects:Β 

Common less serious side effects of NSAIDs include:

  • Gastrointestinal effects: NSAIDs can irritate the lining of the stomach, causing nausea, heartburn, or abdominal pain.
  • Elevated blood pressure: Long-term use of NSAIDs can increase blood pressure, most often in patients with existing hypertension
  • Increased bleeding risk: NSAIDs can potentiate bleeding risk, which can range from mild to severe
  • Allergic reactions: NSAIDs can cause allergic reactions, which most often manifest as skin rashes and irritation

Serious Risks:Β 

More serious risks associated with NSAID use include:

  • Gastrointestinal ulcers Can result from mucosal irritation, potentially causing severe gastrointestinal bleeding
  • Adverse cardiovascular events: Increased risk of heart attack or stroke may result from high NSAID doses or from long-term use
  • Anaphylactic allergic reactions: Rare but potentially adverse effects of NSAID use
  • Acute kidney failure - NSAIDs can affect kidney function, potentially leading to severe, permanent kidney damage

At-Risk Populations:

Certain conditions predispose to a higher risk of adverse effects from NSAID use.

  • Older patients are at heightened risk due to age-related declines in organ function and increased tissue susceptibility.Β 
  • Patients with a known history of gastrointestinal diseases, especially ulcers or gastritis, are more likely to experience NSAID-induced stomach irritation or bleeding.
  • Patients with underlying heart conditions, such as heart disease or hypertension, have a higher risk of cardiovascular complications associated with long-term NSAID use.
  • Those with kidney dysfunction are at significant risk of worsened kidney disease, so NSAIDs should only rarely be used in these cases.
  • The use of multiple medications, such as anticoagulants, corticosteroids, or supplements, along with NSAIDs, is more likely to experience adverse effects, so NSAIDs are contraindicated in patients who are on anticoagulation.

Guidelines for Safe Use of NSAIDs

Dosage and Administration:Β 

When taking NSAIDs, it is necessary to follow the recommended dosage from your healthcare provider or as indicated on the medication label. Do not exceed the recommended dose or take them for longer than prescribed, as this will increase the risk of adverse effects.Β 

NSAIDs should always be taken with food to reduce the risk of gastrointestinal side effects. Be sure to discuss other medications you are taking, and avoid smoking or heavy alcohol use while taking NSAIDs, as this can cause severe side effects.Β 

If any adverse effects occur while taking them, stop the NSAID and discuss your concerns with your healthcare provider. Different medications affect patients differently, so NSAIDs should be part of a personalized treatment plan for the best outcomes.

Duration of Use:Β 

Just as it is necessary to stick to the recommended dosage of NSAIDs, it is also vital to take them only for the duration they are prescribed to reduce potential severe side effects.Β 

  • Short-term use of NSAIDs for temporary conditions is generally safer and is associated with fewer adverse effects.Β 
  • Prolonged NSAID use increases the risk of gastrointestinal complications, kidney damage, and adverse cardiovascular events. In patients who need to take NSAIDs long-term, regular monitoring is essential to ensure their safety.

Interactions with Other Medications:Β 

NSAIDs are known to interact with other medications, especially anticoagulant medications and corticosteroids.Β 

  • Combining NSAIDs with anticoagulants can significantly increase the risk of bleeding, so taking them together is not advised.Β 
  • Combining NSAIDs and corticosteroids increases the risk of gastrointestinal irritation, potentially causing ulcers and bleeding.
  • NSAIDs may necessitate higher doses of antihypertensive medications for optimal blood pressure control.Β 

Many supplements can also increase bleeding risk, especially in combination with NSAIDs:

  • Ginkgo biloba
  • Ginseng
  • Curcumin and turmeric
  • Salicylates
  • Milk thistle
  • St. John’s wort

However, combining nonselective NSAIDs with curcumin derivatives, which inhibit COX-2, has been shown to provide better pain relief without a significant increase in gastrointestinal side effects. Additional research is necessary to determine if curcumin compounds may decrease the doses of NSAIDs required to deliver adequate pain relief.Β 

Alternatives to NSAIDs

Alternative pharmacologic agents to help manage pain and inflammation include acetaminophen and corticosteroids.Β 

  • Acetaminophen does not have anti-inflammatory effects but can provide mild to moderate pain relief with a degree of adverse gastrointestinal effects.
  • Corticosteroids are potent anti-inflammatory agents and can be effective for many inflammatory-mediated conditions. However, corticosteroids can cause gastrointestinal bleeding, elevated blood sugar, weight gain, and adrenal dysfunction.

There are many non-pharmacological options to help manage pain, which can be used independently or in combination with medications:

[signup]

Key Takeaways

  • NSAIDs have a wide variety of uses, most commonly to help manage fever, relieve pain, and reduce inflammation.Β 
  • Their anti-inflammatory properties make them applicable to many medical conditions.
  • However, they are not without risk and should be used only for the recommended duration and in the prescribed dosage to minimize occurrences of adverse effects.
  • Applying other complementary treatments with the use of NSAIDs can enhance their efficacy without increasing associated side effects.
  • Following a personalized plan for each patient can help promote safety and optimal health outcomes.
The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

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Abdu N, Mosazghi A, Teweldemedhin S, et al. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study. PLoS One. 2020;15(10):e0238868. https://pubmed.ncbi.nlm.nih.gov/33035226/

Aminoshariae A, Kulild JC, Donaldson M. Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects: An updated systematic review. J Am Dent Assoc. 2016;147(2):98-110. https://pubmed.ncbi.nlm.nih.gov/26562732/

Anderson, S. (2022, May 19). 6 Preventable Risk Factors Associated with Heart Attacks. Rupa Health. https://www.rupahealth.com/post/5-things-to-do-after-a-heart-attack

Ayoub SS. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. Temperature (Austin). 2021;8(4):351-371. https://pubmed.ncbi.nlm.nih.gov/34901318/

Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180:114147. https://pubmed.ncbi.nlm.nih.gov/32653589/

Chang RW, Tompkins DM, Cohn SM. Are NSAIDs Safe? Assessing the Risk-Benefit Profile of Nonsteroidal Anti-inflammatory Drug Use in Postoperative Pain Management. Am Surg. 2021;87(6):872-879. https://pubmed.ncbi.nlm.nih.gov/33238721/

Cloyd, J. (2023, October 2). A Functional Medicine Approach to Stress Management. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-approach-to-stress-management

Cloyd, J. (2023, June 19). A Functional Medicine Post-Stroke Protocol: Testing, Therapeutic Diet, and Integrative Therapy Options. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-post-stroke-protocol-testing-supplements-and-integrative-therapy-options

Cloyd, J. (2023, August 18). A Root Cause Medicine Protocol for Patients with Osteoarthritis: Testing, Therapeutic Diet, and Supportive Supplements. Rupa Health. https://www.rupahealth.com/post/a-root-cause-medicine-protocol-for-patients-with-osteoarthritis-testing-therapeutic-diet-and-supportive-supplements

Cloyd, J. (2023, April 13). A Functional Medicine Protocol for Peptic Ulcers. Rupa Health. https://www.rupahealth.com/post/a-functional-medicine-protocol-for-peptic-ulcers

Cloyd, J. (2023, April 25). Drug Interactions with Common Herbs and Supplements. Rupa Health. https://www.rupahealth.com/post/drug-interactions-with-common-herbs-and-supplements

Cryer B, Barnett MA, Wagner J, Wilcox CM. Overuse and Misperceptions of Nonsteroidal Anti-inflammatory Drugs in the United States. Am J Med Sci. 2016;352(5):472-480. https://pubmed.ncbi.nlm.nih.gov/27865294/

Diorio, B. (2023, February 21). What is Integrative Medicine Pain Management? Rupa Health. https://www.rupahealth.com/post/what-is-integrative-medicine-pain-management

Enthoven WT, Roelofs PD, Deyo RA, van Tulder MW, Koes BW. Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database Syst Rev. 2016;2(2):CD012087. https://pubmed.ncbi.nlm.nih.gov/26863524/

Feng X, Wang X. Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis. Mol Pain. 2018;14:1744806918770320. https://pubmed.ncbi.nlm.nih.gov/29587566/

Gong L, Thorn CF, Bertagnolli MM, Grosser T, Altman RB, Klein TE. Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012;22(4):310-318. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303994/#:~:text=The%20anti%2Dinflammatory%20and%20pain,(encoded%20by%20gene%20PTGS2).

Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16(5):821-847. https://pubmed.ncbi.nlm.nih.gov/24393558/

Kaduőevičius E. Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy. Int J Mol Sci. 2021;22(12):6637. https://pubmed.ncbi.nlm.nih.gov/34205719/

Khatchadourian ZD, Moreno-Hay I, de Leeuw R. Nonsteroidal anti-inflammatory drugs and antihypertensives: how do they relate?. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(6):697-703. https://pubmed.ncbi.nlm.nih.gov/24755117/

Mehuys E, De Backer T, De Keyser F, et al. Prevalence and management of drug interactions between nonsteroidal anti-inflammatory drugs and antithrombotics in ambulatory care. Br J Clin Pharmacol. 2022;88(8):3896-3902. https://pubmed.ncbi.nlm.nih.gov/35184333/

Moore N, Pollack C, Butkerait P. Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs. Ther Clin Risk Manag. 2015;11:1061-1075. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508078/

Morelli KM, Brown LB, Warren GL. Effect of NSAIDs on Recovery From Acute Skeletal Muscle Injury: A Systematic Review and Meta-analysis. Am J Sports Med. 2018;46(1):224-233. https://pubmed.ncbi.nlm.nih.gov/28355084/

Olry de Labry Lima A, Salamanca-FernÑndez E, Alegre Del Rey EJ, Matas Hoces A, GonzÑlez Vera MÁ, Bermúdez Tamayo C. Safety considerations during prescription of non-steroidal anti-inflammatory drugs (NSAIDs), through a review of systematic reviews. An Sist Sanit Navar. 2021;44(2):261-273. https://pubmed.ncbi.nlm.nih.gov/34170889/

Pflipsen MC, Vega Colon KM. Anaphylaxis: Recognition and Management. Am Fam Physician. 2020;102(6):355-362. https://pubmed.ncbi.nlm.nih.gov/32931210/

Ribeiro H, Rodrigues I, NapoleΓ£o L, et al. Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features. Biomed Pharmacother. 2022;150:112958. https://pubmed.ncbi.nlm.nih.gov/35453005/

Shep D, Khanwelkar C, Gade P, Karad S. Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial. Medicine (Baltimore). 2020;99(16):e19723. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220260/

Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev. 2004;56(3):387-437. https://pubmed.ncbi.nlm.nih.gov/15317910/

Stanford, J. (2024, March 20). Combating Chronic Pain with Anti-Inflammatory Eating: A Nutritional Approach. Rupa Health. https://www.rupahealth.com/post/combating-chronic-pain-with-anti-inflammatory-eating-a-nutritional-approach

Stanford, J. (2023, February 15). Top 10 Anti-Inflammatory Foods to Include in Your Diet. Rupa Health. https://www.rupahealth.com/post/top-10-anti-inflammatory-foods-to-include-in-your-diet

Tai FWD, McAlindon ME. Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Clin Med (Lond). 2021;21(2):131-134. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002800/

Tsoi KKF, Ho JMW, Chan FCH, Sung JJY. Long-term use of low-dose aspirin for cancer prevention: A 10-year population cohort study in Hong Kong. Int J Cancer. 2019;145(1):267-273. https://pubmed.ncbi.nlm.nih.gov/30575949/

US Preventive Services Task Force, Davidson KW, Barry MJ, et al. Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2022;327(16):1577-1584. https://pubmed.ncbi.nlm.nih.gov/35471505/

Yoshimura, H. (2023, May 26). Integrative Approaches to the Treatment of Gout: A Comprehensive Review. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-the-treatment-of-gout-a-comprehensive-review

Weinberg, J. (2023, June 21). Integrative Approaches to the Treatment of Osteoarthritis: A Comprehensive Review. Rupa Health. https://www.rupahealth.com/post/integrative-approaches-to-the-treatment-of-osteoarthritis-a-comprehensive-review

Williams DM. Clinical Pharmacology of Corticosteroids. Respir Care. 2018;63(6):655-670. https://pubmed.ncbi.nlm.nih.gov/29794202/

Williams K. Evidence on NSAID use in soft tissue injuries. Nurs Times. 2012;108(45):12-14. https://pubmed.ncbi.nlm.nih.gov/23240270/#:~:text=NSAIDs%20have%20been%20used%20for,to%20their%20effect%20on%20inflammation.

Yoshimura, H. (2023, October 23). Are Supplements Really Necessary? Pros, Cons, and How Testing Can Help. Rupa Health. https://www.rupahealth.com/post/are-supplements-really-necessary-pros-cons-and-how-testing-can-helpΒ 

Yoshimura, H. (2023, December 5). Harnessing the Power of Mind-Body Techniques for Chronic Pain Management. Rupa Health. https://www.rupahealth.com/post/harnessing-the-power-of-mind-body-techniques-for-chronic-pain-management

Yoshimura, H. (2023, November 7). The Remarkable Power of Exercise on Our Health: A Comprehensive Overview. Rupa Health. https://www.rupahealth.com/post/the-remarkable-power-of-exercise-on-our-health-a-comprehensive-overview

Yoshimura, H. (2023, April 11). Using Acupuncture for Chronic Pain Management. Rupa Health. https://www.rupahealth.com/post/using-acupuncture-for-chronic-pain-management

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