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What Are the Benefits of Collagen Peptides?

Medically reviewed by 
 What Are the Benefits of Collagen Peptides?

Collagen peptides have gained popularity as a widely embraced dietary supplement. As a vital protein in the human body, the increasing interest in collagen is driven by its many potential health and wellness benefits. This article delves into the positive impacts they may have on overall well-being.


What Are Collagen and Collagen Peptides?

Collagen is the most abundant protein in the body, constituting about 30% of the total protein. It is  the primary building block for connective tissues, including the skin, muscles, bones, tendons, ligaments, organs, blood vessels, and intestinal lining.

Playing a key role in maintaining the structural integrity of tissues, collagen offers both strength and elasticity to the skin, protects the organs, facilitates new cell growth in the dermis (middle skin layer), and contributes to blood clotting.

Collagen peptides are produced in a lab through hydrolysis, a process that alters whole collagen. Whole collagen refers to collagen protein in its natural state, a complex structure consisting of three long, intertwined chains of amino acids, the fundamental building blocks of protein. Most commonly, collagen is derived from bovine (cow), porcine (pig), or marine (fish) sources.

Hydrolysis begins with a denaturation phase, heating the collagen above 40oC to separate the three chains. Subsequently, protein-degrading enzymes like papain and pepsin break down these chains, resulting in hydrolyzed collagen (HC). HC consists of small peptides or short chains of amino acids. While chemical processes can also be used for protein hydrolysis, enzymatic methods are preferred due to their ability to maintain the nutritional value of the protein source.

Collagen peptides, being much smaller than whole collagen, offer enhanced bioavailability or easier absorption and digestibility in the human body. Notably, collagen peptides exhibit the ability to bind to calcium ions, making them more accessible for the body's use. Additionally, they display antioxidant activity by fighting harmful substances, making them valuable in functional food supplements.

Key Benefits of Collagen Peptides

Collagen peptides have been investigated for their diverse benefits in health and wellness.

Skin Health

Collagen peptides significantly enhance skin elasticity and hydration, with evidence supporting their potential to reduce wrinkles and combat signs of aging. Their positive impact on skin moisture and elasticity is  attributable to collagen’s role in supplying structural support and promoting an increase in fibroblasts. These cells, responsible for collagen secretion and connective tissue formation, play a key role in producing extracellular matrix (ECM), a complex network of connective tissue offering structural support to surrounding cells.

Collagen peptide supplementation has also been shown to inhibit matrix metalloproteinases (MMPs), enzymes that degrade the ECM, thus preserving skin integrity and slowing signs of aging.

Moreover, collagen peptides exhibit promise in addressing photoaging skin– premature aging caused by prolonged exposure to sunlight. Common signs include wrinkles, fine lines, sagging skin, reduced elasticity, and uneven pigmentation. By regulating signaling pathways like MAPK and NF-κB, collagen peptides contribute to enhanced antioxidant activity and the scavenging of reactive oxygen species (ROS), offering a potential defense against the effects of photoaging.

Joint and Bone Health

Collagen peptides also exhibit promising potential in supporting joint health, alleviating discomfort, and contributing to bone density.  This is especially beneficial for individuals with osteoarthritis or those at risk of bone density loss.

Evidence suggests positive effects of collagen peptide supplementation on joint function, recovery from joint injuries, and joint pain, especially when combined with exercise. It may stimulate collagen synthesis in the articular cartilage, thereby preventing tissue damage and reducing pain.

Moreover, there is speculation about the anti-inflammatory properties of collagen peptides, attributed to glycine, an amino acid present in collagen, known to inhibit the release of proinflammatory molecules like interleukin-6 (IL-6).  Research has shown significant pain relief in knee osteoarthritis patients with collagen peptide supplementation over placebo. 

A study conducted on middle-aged active adults without osteoarthritis reported that daily intake of 10-20 g of collagen peptides over 6-9 months may help improve daily activities, reduce joint pain, and enhance mental and physical well-being.

In a 2018 study, postmenopausal women with age-related reductions in bone mineral density (BMD) experienced enhanced BMD after one year of consuming 5 g of collagen peptides daily compared to the control group, emphasizing the potential benefits of supplementation for bone health.

Muscle Mass and Strength

Collagen peptides may enhance muscle mass  and strength, improve body composition, and aid in muscle soreness relief and recovery post-exercise.

In a recent study, researchers investigated the impact of collagen peptide supplementation on muscle strength and growth during lower-body resistance training. Young, healthy men received either 15g of collagen peptides or placebo. Both groups followed the same leg-focused workout plan for 15 weeks. The results indicated similar strength gains in both groups, but the collagen group showed greater increases in muscle size, particularly in the quadriceps.

In a 2019 study, recreationally active men underwent 12 weeks of resistance training combined with a daily intake of 15g of collagen peptides or placebo. The collagen peptide group experienced a significant increase in fat-free mass (muscle) and no change in body fat, while the placebo group experienced an increase in body fat. Strength improvements were similar in both groups, but there were no significant differences in muscle fiber size.

Similarly, in a 12-week study involving premenopausal women engaging in resistance training, those who supplemented with collagen peptides demonstrated significant enhancements in muscle mass, reduced body fat, and increased hand grip and leg strength compared to the placebo group.

While collagen may have a lower muscle protein synthesis response compared to other protein sources like whey, its supplementation alongside exercise appears beneficial for overall musculoskeletal health and recovery. However, further research is needed to understand its effectiveness fully.

Gut Health

Collagen peptides are believed to support gut health by promoting the integrity of the gut lining. This is significant for individuals with leaky gut syndrome or other digestive health issues.

The gut lining is crucial in preventing harmful substances from leaking into the bloodstream and causing inflammation and other health problems. Collagen peptides are thought to help strengthen and repair the gut lining. Glycine, the most abundant amino acid in collagen, may enhance intestinal barrier function and reduce oxidative stress and inflammation by regulating tight junctions between cells.

Some studies suggest that collagen peptides may also exert prebiotic effects, promoting a healthy gut microbiome and producing beneficial short-chain fatty acids that fuel the intestinal cells and create an anti-inflammatory environment.

Hair and Nail Growth 

Collagen peptides have gained attention for their potential to improve hair and nail health, supported by both anecdotal reports and emerging scientific research. Many individuals have reported enhanced hair texture, strength, and growth, along with improved nail strength and appearance after incorporating collagen peptides into their daily routine.

Recent studies have delved into the biological mechanisms underlying these effects. One study found that 24 weeks of collagen peptide treatment led to a 12% increase in nail growth rate and a 42% reduction in broken nail frequency. Additionally, 65% of participants experienced overall improvement in brittle nails, with 88% reporting sustained benefits one month post-treatment.

Another study focusing on collagen peptides derived from fish for hair health revealed promising results, including enhanced hair cell growth and the promotion of new hair follicle generation. Another study yielded similar results, in addition to evidence of reduced oxidative stress and decreased inflammatory markers with supplementation. However, these findings were observed in cell cultures, and further research involving human subjects is needed to validate these outcomes.

Incorporating Collagen Peptides into Your Diet

Incorporating collagen peptides into your diet can be easy and convenient with a variety of forms available based on preference, including powders, capsules, and beverages. Recommended dosing can vary based on individual goals, however, doses in the range of 2.5-15g per day are most common. It is always advised to follow the specific recommendations provided on the product label or consult a healthcare professional for personalized advice.

Here are some practical tips for integrating collagen powders into your daily routine:

  • Mix into a beverage: Add a scoop of collagen peptide powder to your morning coffee, tea, smoothie, or glass of water for an extra boost of protein and nutrients.
  • Blend into a smoothie: Combine your collagen peptide powder with fruits, a handful of greens, and your choice of liquid (water, almond milk, juice) to create a nutritious and delicious smoothie.
  • Add into foods: Collagen peptides may be stirred into foods like oatmeal, yogurt, or soups.  Simply mix the powder into the food until fully incorporated.
  • Bake with it: Add the powder to recipes for breads, muffins, or cookies. However, be mindful of excessive sugar intake with this method.

Feel free to get creative to determine what method works best for you. By following these practical tips, you can easily integrate collagen peptides into your diet to reap their many potential health benefits.

Safety and Considerations

Collagen peptide supplementation is generally considered safe. However, individuals with allergies, particularly to shellfish, should exercise caution, as some collagen supplements are derived from marine sources. It is essential to carefully review product labels for allergens before use. While some sources report concerns with porcine and bovine collagen related to diseases like swine flu and bovine spongiform encephalopathy (BSE), data on this is limited.

Regarding use in pregnant and breastfeeding women, there is not enough reliable data to confirm the safety of collagen peptides. While some sources suggest its safety and efficacy, caution is warranted until further research is conducted in this population.

As the demand for collagen grows across various industries, including pharmaceuticals, cosmetics, and food, there is an increasing focus on sustainability and product quality. Utilizing collagen from fishing waste products, such as fish skin and bones, as well as organisms caught unintentionally, like jellyfish and sharks, presents a more sustainable approach with reduced environmental impact. However, it is crucial to consider factors like sourcing, extraction methods, and geographical location to ensure the nutritional quality and sustainability of collagen products.

Comparing Collagen Peptides with Other Forms of Collagen

Collagen supplements are available in various forms, including collagen peptides, gelatin, and undenatured collagen.

Gelatin undergoes denaturation (heating), similar to collagen peptides, but the process stops there, resulting in larger molecules. Gelatin is commonly used in the food industry as an emulsifier or thickening agent. Its larger size may affect absorption and bioavailability.

Conversely, undenatured collagen retains its natural structure, with the three long, intertwined chains intact. It is, therefore, even larger in size. It is also resistant to proteases (enzymes that break down proteins), non-soluble in water, and contains antigenic sites, which may trigger immune responses that cause intolerance in some individuals.

Collagen peptides are smaller and more easily absorbed. They are water-soluble and can be easily dissolved in liquids. Although collagen peptides may be more expensive due to specialized processing, they offer superior bioavailability, convenience, and digestibility compared to other forms of collagen. Therefore, individuals seeking to support their overall health and well-being may choose collagen peptides for their enhanced properties.

The Science Behind Collagen Peptides

The scientific evidence supporting the benefits of collagen peptides is promising but still requires further investigation. Studies typically have small sample sizes, dosing recommendations vary, and the efficacy of collagen supplements across different populations and potential long-term impacts remain uncertain.

While collagen peptides hold promise for joint health and pain relief in osteoarthritis, further research is needed to elucidate their action and how they compare to other protein supplements. Future studies should target the effects of collagen peptides in females, who are more susceptible to connective tissue injuries, and explore their role in musculoskeletal injury recovery for athletes. Uncertainty remains about collagen peptide mechanisms, emphasizing the need for more controlled studies with precise outcome measures, including laboratory analysis and advanced imaging techniques.

In terms of hair and nail growth, research conducted in living organisms (in vivo) is needed to understand better how collagen peptides work and their effects within the body.

While initial evidence has provided insights into the clinical benefits of collagen peptides, further research is warranted to validate and strengthen these findings. Continued investigation will enhance the understanding of the efficacy and safety of collagen peptides as a therapeutic option for various conditions, ultimately providing more robust evidence for clinical decision-making.


Key Takeaways

Collagen peptides offer a range of potential health benefits, from skin and joint health to muscle strength and gut integrity. 

It is important to consider individual health goals and consult with healthcare professionals before incorporating them into your routine.

Collagen peptides show significant potential as a therapeutic option for various conditions, highlighting the importance of ongoing research to fully understand their mechanisms.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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