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Complementary and Integrative Medicine Approach to OCD: Testing, Therapies, and Supplements

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Complementary and Integrative Medicine Approach to OCD: Testing, Therapies, and Supplements

Obsessive-Compulsive Disorder (OCD) is a mental health condition that affects approximately 1 in 100 adults in the United States, significantly impacting their daily lives and relationships. Traditional treatment methods, such as cognitive-behavioral therapy and medication, have proven effective for many individuals. However, an increasing number of patients and practitioners are exploring integrative and functional medicine approaches to address the symptoms of OCD and improve overall mental health. This article will look at symptoms, potential causes, diagnostic methods, and functional medicine tests for OCD, as well as conventional and complementary treatments.


What is OCD?

OCD is a chronic mental health condition and is characterized by recurrent, unwanted thoughts or repetitive behaviors that a person must carry out. These behaviors often cause significant distress and interfere with daily functioning, affecting personal and professional relationships (2).

Symptoms of OCD

Individuals with OCD can exhibit a variety of symptoms associated with obsessive thoughts, compulsive actions, or both. These symptoms can profoundly affect different life aspects, such as work, education, and personal relationships (2).

Obsessive thoughts are persistent, anxiety-inducing mental images, urges, or ideas. Common obsessive thoughts include (2):

  • Concerns about germs or contamination
  • Inappropriate or taboo thoughts related to sex, religion, or causing harm
  • Hostile thoughts directed at oneself or others
  • The desire for orderliness and precision

Compulsive behaviors are repetitive actions that an individual with OCD feels driven to perform in response to an obsessive thought. Common compulsive behaviors include (2):

  • Over-cleaning and excessive handwashing
  • Organizing objects in a specific pattern
  • Continually checking things, like ensuring doors are locked or appliances are off
  • Habitual counting

It is important to note- not all routines or rituals are compulsive behaviors. However, a person with OCD typically (2):

  • Has difficulty controlling their thoughts or actions, even when aware of their excessiveness
  • Spends an hour or more daily on these obsessive thoughts or actions
  • Does not enjoy engaging in the behaviors or rituals but might feel temporary relief from the associated anxiety
  • Faces substantial challenges in daily life due to these thoughts or actions

Additionally, some individuals with OCD may present with a tic disorder, which involves motor tics such as abrupt, short, repetitive movements (e.g., eye blinking, facial grimacing, shoulder shrugging) (2).

What Causes OCD?

Additional research is warranted to understand the exact cause of OCD, but many factors are thought to contribute (2):

Family history: While the exact reason is still unknown, a genetic predisposition to OCD has been identified. Individuals are more likely to develop OCD if a family member also has the condition.

Brain structure and functioning: Imaging studies have suggested that abnormalities in the brain's structure or functioning may contribute to OCD. Research completed specifically on neurotransmitters has shown dysregulation in glutamate, serotonin, and dopamine.

Traumatic or stressful life events: Childhood abuse or a significant loss may trigger the onset of OCD.

How is OCD Diagnosed?

OCD is typically diagnosed by a psychiatrist or psychologist who conducts a clinical interview and assesses symptoms. An OCD diagnosis involves having constant thoughts or repetitive actions that take up to over an hour daily, leading to considerable distress and negatively affecting your job or social life. The clinician may use standardized assessment tools, such as the Yale-Brown Obsessive-Compulsive Scale Second Edition (Y-BOCS-II), to evaluate the severity of the disorder.

Functional Medicine Labs to Test That Can Help Individualize Treatment for OCD Sufferers

Some tests to consider for patients with OCD include stool testing, neurotransmitter testing, and sleep and stress testing.


The GI-MAP test from Diagnostic Solutions uses advanced qPCR technology to identify the DNA of various microbes in your stool, such as bacteria, parasites, fungi, and viruses. This can help pinpoint infections, imbalances, and gut dysbiosis. Gut health has been frequently linked to mental health. Since about 95% of serotonin, a brain chemical linked to OCD, is produced in the gut, improving gut health may lead to better overall wellness. Additionally, the test measures markers of inflammation, digestion, and immune function.

Neurotransmitter Testing for OCD

The NeuroAdvanced Profile by ZRT Laboratory is a dried urine test that evaluates neurotransmitter levels, specifically beneficial for individuals with OCD. As described above, neurotransmitter imbalances, such as glutamate, dopamine, and serotonin, have been linked to OCD symptoms. By identifying these imbalances, targeted interventions can be devised to help restore balance, potentially improving mood and behavior for those struggling with this disease.

Sleep and Stress Panel for OCD

The Ayumetrix Sleep and Stress Panel is a comprehensive test that assesses various hormones and markers related to sleep and stress, which can be helpful for individuals with OCD. Research has shown that sleep disturbances and circadian abnormalities are common in OCD patients and are often linked to the severity of symptoms, depression, and anxiety. This test evaluates hormones such as cortisol and melatonin, which play essential roles in regulating sleep and stress. By identifying imbalances in these hormones, targeted interventions can be devised to address sleep and stress issues affecting those with this disorder (11,12).

Micronutrient Testing for OCD

The SpectraCell Micronutrient Test is a comprehensive assessment that measures the levels of essential vitamins, minerals, and antioxidants in an individual's blood, which can be particularly valuable for those seeking to optimize their mental health. A well-balanced diet rich in nutrients like omega-3 fatty acids, B vitamins, and magnesium plays a critical role in supporting brain function and mood regulation. Identifying any deficiencies or imbalances enables targeted interventions through diet or supplementation.


Conventional Treatment for OCD

In addressing OCD, a blend of psychotherapy and medications is often used. Utilizing cognitive behavioral therapy (CBT), particularly exposure and response prevention has been instrumental in assisting people in navigating their obsessions and compulsions. Medications play a crucial role, with antidepressants like fluoxetine and sertraline routinely prescribed for symptom management.

Complementary and Integrative Medicine for OCD

While conventional treatments like CBT and medication are effective for many people with OCD, some individuals may also benefit from complementary and integrative medicine approaches. Here are a few options to consider:

Nutrition Options for Mental Health

A well-balanced diet and a healthy gut microbiome can significantly influence one's mood and overall well-being; research suggests that the gut microbiome, consisting of numerous microbial cells and viruses, plays a crucial role in mental health and disorders by affecting cognitive and emotional processes. In addition to this, consuming an anti-inflammatory, whole-foods, nutrient-dense diet rich in omega-3s, polyphenols, and phytonutrients can support mental health by reducing inflammation, quenching oxidative stress, and providing the necessary nutrients for optimal cognitive functioning (15,16).

A diet rich in dietary fiber and omega-3 polyunsaturated fatty acids may lower the risk of developing symptoms of depression, anxiety, and stress; foods high in folate and other B vitamins, like leafy greens, are vital for brain function and mood regulation. Omega-3 fats, found in seaweed, wild fish, wild-caught salmon, avocado, nuts, and seeds, are critical for cognition, immune and inflammatory function, and brain development. Seafood is also an excellent source of omega-3s, protein, B12, zinc, and vitamin D, all of which contribute to our mental health (14).

Prebiotic consumption has been shown to improve anxiety and depression and enrich bifidobacteria in individuals consuming at least 5 grams per day. Some examples of prebiotic foods include garlic, chicory root, and sunchokes. Probiotic-rich foods, like kombucha, kimchi, and yogurt, can counteract dysbiosis and support mental health. Additionally, certain nutrients like magnesium, vitamin D, and zinc play essential roles in regulating mood and emotions. A deficiency in these nutrients can affect brain function and lead to mental health problems (14,17).

Supplements and Herbs for OCD

Some evidence-based supplements and herbs that may help alleviate OCD symptoms include:

Ashwagandha (Withania somnifera) for OCD

Ashwagandha is a powerful adaptogenic herb with potential benefits for reducing OCD symptoms. One of the primary reasons ashwagandha is beneficial for those with OCD is its potential to reduce stress levels. As OCD is an anxiety disorder, adaptogens like ashwagandha may help patients due to their stress-reducing effects. Specifically, they work by modulating the body's stress response, which can help promote a sense of calm and balance in the face of the repetitive thoughts and compulsive behaviors characteristic of OCD. A randomized, double-blind, placebo-controlled trial involving participants with OCD examined the effects of ashwagandha extract on their symptoms. The study found that the ashwagandha group experienced a notable and statistically significant reduction in OCD symptoms compared to the placebo group.

Dose: 120 mg/day

Duration: 6 weeks

Zinc for OCD

Zinc is a crucial trace element with an interesting role in alleviating OCD symptoms. One of the key reasons zinc could be beneficial for those with OCD is its capacity to influence the brain's communication system, specifically the glutamatergic system. As OCD is a condition that disrupts the normal flow of these brain signals, elements like zinc that can help control this system may aid patients, especially ones who have been found to have abnormal glutamate levels upon testing. Specifically, zinc works by adjusting the activity of certain brain receptors, promoting a balance in the brain's signaling that can alleviate the intrusive thoughts and repetitive behaviors seen in OCD. A double-blind, placebo-controlled trial involving participants with OCD examined the effects of zinc supplementation. The study discovered that the group taking zinc alongside their regular medication (fluoxetine) experienced a modest yet statistically significant reduction in OCD symptoms compared to the placebo group.

Dose: 440 mg/day (220 mg twice daily)

Duration: 8 weeks

N-Acetylcysteine for OCD

N-Acetylcysteine (NAC) is an amino acid that may offer benefits in relieving OCD symptoms, particularly for individuals who have shown resistance to selective serotonin reuptake inhibitor (SSRI) therapy. The connection between NAC and OCD symptoms is rooted in its ability to modulate glutamate levels in the brain. Glutamate is a neurotransmitter that has been linked to OCD symptoms, making NAC's role in managing its levels potentially beneficial. In a 12-week study, participants resistant to SSRI medication were given daily doses of up to 2,400 mg of NAC. The response rate, defined as a 35% reduction in symptoms or more, escalated from 15% in the placebo group to 52.6% in the NAC group. This suggests that NAC can potentially counteract or reduce resistance to SSRI therapy, leading to improved outcomes. This therapeutic effect of NAC corresponds well with the insights gained from Neurotransmitter Testing for OCD, which measures the levels of neurotransmitters like glutamate.

Dose: 2,400 mg/day

Duration: 12 weeks

Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT) for OCD

Both mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR) are promising treatment options for individuals with OCD. These approaches, which focus on increasing awareness and acceptance of intrusive thoughts without attaching significance to them, have shown positive outcomes in reducing OCD symptoms. Both MBCT and MBSR have been effective in reducing depressive and anxiety symptoms and preventing relapses in unipolar depression. They can potentially address cognitive biases specific to OCD, such as dysfunctional beliefs, leading to symptom improvement. In addition, mindfulness has also demonstrated an ability to increase melatonin levels and reduce cortisol levels. (23,24,25).

Exercise for OCD

Exercise has shown potential as a supplementary treatment for individuals with OCD. While access to traditional OCD treatments may be limited, exercise is a readily available option that can provide various benefits. Aerobic exercise has also shown promise in reducing anxiety and improving mood in treatment-resistant OCD patients (26).

Sleep Hygiene for OCD

Quality sleep plays a pivotal role in managing OCD symptoms, largely due to its impact on neurotransmitter levels. Neurotransmitters are chemical messengers found in the brain, and are instrumental in regulating our mood, behavior, and sleep patterns. In individuals with OCD, neurotransmitters like serotonin, glutamate, and dopamine are often out of balance. This imbalance may contribute to the disorder's intrusive thoughts and compulsive behaviors. These neurotransmitters play a role in sleep quality. For instance, serotonin, which is mostly produced in the gut, plays a key role in mood and cognition. A good night's sleep can aid in maintaining optimal serotonin levels, thereby potentially reducing OCD symptoms. Similarly, glutamate, an excitatory neurotransmitter found in many foods (such as cheese and nuts), is implicated in OCD. Its levels can be controlled by a healthy sleep routine, which may in turn help manage the intensity of OCD symptoms. Dopamine, another neurotransmitter related to body movement and pleasure, is also involved in OCD. The regulation of dopamine is associated with sleep, and thus maintaining a healthy sleep schedule can be beneficial for managing OCD symptoms.

Acupuncture for OCD

Acupuncture is an ancient Chinese healing technique used for centuries to alleviate pain, reduce stress, and promote general health. The painless insertion of thin needles at specific points along the body has shown promising results for the treatment of OCD and anxiety-related conditions. In a pilot study, electroacupuncture, which involves passing a small, gentle electrical current through acupuncture needles, significantly reduced OCD symptoms and improved patients' conditions when used as an additional therapy alongside anti-OCD medications. These findings suggest that acupuncture can be an effective complementary treatment option for individuals suffering from OCD.



In conclusion, OCD is a mental health disorder that can greatly impact the quality of one's life. While conventional treatments like CBT and medication are effective for many people, complementary and integrative approaches—including nutrition, supplements, and alternative therapies such as acupuncture—may offer additional support in managing OCD symptoms. A personalized, holistic approach to treatment, tailored to an individual's unique needs and circumstances, may provide the best outcomes for those living with OCD.

The information provided is not intended to be a substitute for professional medical advice. Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
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