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Reference Guide
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ST2
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ST2
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Growth Stimulation Expressed Gene 2

What's 
ST2
?
ST2 is a protein found in humans that is created by the IL1RL1 gene. It belongs to the interleukin-1 receptor family, which is a group of proteins that play an important role in our immune system's response to swelling and infection. There are two types of ST2: a transmembrane form (ST2L) that sends signals within cells, and a soluble form (sST2) that travels in our bloodstream. The soluble form, sST2, is especially interesting because it acts like a sponge, absorbing another protein called IL-33. This interaction between sST2 and IL-33 is essential for controlling immune responses and inflammation in our body.
If Your Levels Are High
Elevated ST2 levels might mean that your immune system is working extra hard, possibly due to ongoing inflammation, lingering infections, or certain autoimmune conditions like lupus or rheumatoid arthritis. External factors, such as specific medications like corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs), or exposure to environmental toxins, could also contribute to higher ST2 levels. It's important to remember that ST2 is just one part of the bigger picture when it comes to understanding your immune system and overall health, so it's essential to consider these levels in the context of your complete well-being.
Symptoms of High Levels
Symptoms of high levels of ST2 may not be specific and can vary widely, but they could include general signs of inflammation such as fatigue, joint pain, and unexplained weight changes.
If Your Levels are Low
Low ST2 levels might mean that your body isn't as good at controlling inflammation and immune responses as it should be. This could be due to various reasons like being stressed out, not eating well, not getting enough sleep, or taking certain medications that affect your immune system. It could also point to specific health issues like autoimmune disorders or ongoing inflammatory diseases. Keep in mind that ST2 levels can change over time and may not always give a complete picture of your overall health.
Symptoms of Low Levels
Symptoms of low levels of ST2 may not be easily noticeable, as they can overlap with symptoms of general poor health or chronic illness. These could include fatigue, frequent infections, slow wound healing, or unexplained body aches and pains.

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Growth Stimulation Expressed Gene 2

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