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Reference Guide
Precision Point

Precision Point

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Precision Point
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Vibrant & Rupa Partnership Ended Feb 1st.
Vibrant Wellness & America are no longer available on platforms like Rupa, but we’ve created a list of comparable tests. You can also talk to a Rupa rep to help you transition to alternatives! Learn more.

About the Lab

Precision Point Diagnostics specializes in Functional Diagnostics focusing on Allergy, Sensitivity, and Intestinal Permeability testing.

They aim to provide the best allergy and gut testing platform and support a targeted approach to care for the whole person. 

They offer diagnostic testing of the gastrointestinal tract, immune system, hormones, toxins, nutritional markers, and inflammation to facilitate individualized health care planning.

About Precision Point Diagnostics

Precision Point Diagnostics was founded by two integrative medicine practitioners who aimed to support other practitioners using their tests to diagnose and manage gut dysbiosis, leaky gut, food allergies, and food sensitivities, conditions commonly addressed by Functional Medicine. 

Their unique profiles encompass comprehensive approaches to patient care.  Additionally, they collaborate with physicians to identify suitable treatments for optimal wellness without undesirable side effects.

They believe that to achieve long-term symptom resolution, treatment focus must extend beyond mere diagnosis.  Diagnostic testing of the GI tract, immune system, hormones, toxins, nutritional markers, and inflammation is vital to begin crafting a personalized treatment plan that supports the whole person. 

Mission and Values

They strive to offer high standard, innovative diagnostic testing to determine the root cause of a disease, promoting “a targeted approach to wellness.”

Testing Technology and Methods

At the core of Precision Point Diagnostics' testing services is the use of ELISA (Enzyme-Linked Immunosorbent Assay) technology. This methodology is pivotal for assessing the presence of antibodies such as IgE, IgG, IgG4, and Complement C3d in various biological samples, including plasma/serum, saliva, urine, and stool. 

Commitment to Quality and Education

Precision Point Diagnostics not only adheres to stringent quality control measures but also fulfills various certification and accreditation requirements to ensure the reliability and reproducibility of their testing methods and results. 

Their approach is enriched by a foundation in naturopathy, nutrition, and functional medicine, which informs their research and development processes. Furthermore, the company is dedicated to educating both practitioners and patients about their tests and results, providing resources that enhance understanding of how these results correlate to overall health and wellness. 

To support this educational goal, they offer free consultations with their physicians to practitioners, ensuring that the insights gained from testing are effectively integrated into patient care.

Testing Standards at Precision Point Diagnostics

Precision Point Diagnostics is committed to excellence in all aspects of its diagnostic testing services. This commitment is reflected in the stringent standards they uphold to ensure accuracy, reliability, and consistency in their test results.

Quality Assurance and Accreditation

Precision Point Diagnostics is CLIA-certified and COLA-accredited.

Testing Technologies

Precision Point Diagnostics' testing services include advanced technologies such as ELISA technology for detecting specific antibodies. This technology allows for precise measurement of immune responses, which is crucial for identifying allergies, sensitivities, and other immune-related conditions. 

They also employ PCR testing for many of their digestive function tests.  

Support and Resources for Practitioners

The value of diagnostic tests lies in their correct interpretation and integration into patient care: to this end Precision Point Diagnostics provides extensive support and resources to healthcare practitioners. 

This includes detailed explanations of test results, correlations to health conditions, and implications for treatment strategies. Moreover, Precision Point offers practitioners free consultations with their expert physicians, facilitating a deeper understanding of complex cases and fostering a collaborative approach to healthcare that is informed by accurate diagnostic data.

Popular Tests Offered by Precision Point Diagnostics

Precision Point Diagnostics offers a wide array of advanced diagnostic tests that cater to various health needs, from allergy identification to comprehensive hormonal assessments. 

P88-DIY Dietary Antigen Test and P88 Dietary Antigen Test

The P88-DIY Dietary Antigen Test utilizes blood spot or serum testing to analyze IgE, IgG, IgG4, and complement (C3d) reactions to 88 foods to identify food allergies and sensitivities.

The test provides a semi-qualitative assessment, classifying patient reactivity into three classes (Low, Moderate, or High) based on a quartile system.  This approach ensures that each antigen has a unique reference range.  The test demonstrates high precision (95% intra-assay and 94% inter-assay) and linearity (>99%).

The test results inform two diet options for patients: a more restrictive diet that eliminates all foods testing positive at a moderate to high level and rotates mildly reactive foods, and a less restrictive diet that only eliminates foods resulting in high or moderate results with complement reactions. Follow-up testing is recommended 3-6 months after diet implementation. 

Advanced Intestinal Barrier Assessment (IBA)

Precision Point Diagnostics' Advanced IBA profile offers a comprehensive analysis of intestinal barrier function to diagnose intestinal permeability, or "leaky gut." This condition is linked to autoimmune diseases, systemic inflammation, and food sensitivities. 

The Advanced IBA profile features clinically relevant markers that provide a detailed assessment of gut health. Histamine and diamine oxidase (DAO) levels indicate histamine balance and gut mucosal health. Plasma Zonulin levels reflect intestinal tight junction integrity, while Lipopolysaccharide (LPS) antibodies indicate inflammation and permeability. 

This profile is beneficial for patients with various symptoms, including allergies, food sensitivities, digestive issues, headaches, cognitive decline, and depression.

Comprehensive Thyroid Panel

Precision Point Diagnostics' Comprehensive Thyroid Panel w/Antibodies and Reverse T3 offers a thorough assessment of thyroid function.  This test provides a detailed view of thyroid health by measuring TSH, T3 (free and total), T4 (free and total), and anti-thyroglobulin and thyroid peroxidase antibodies as well as reverse T3, going beyond routine tests that only measure TSH and total T4.

Advanced Adrenal Stress Test

Precision Point Diagnostics’ Adrenal Stress Test assesses cortisol, DHEA, and secretory IgA (sIgA) levels in saliva, providing insights into adrenal function.  Cortisol levels can impact fatigue, insomnia, thyroid disorders, and weight gain, while low cortisol levels may lead to blood pressure dysregulation, irritability, hypoglycemia, anxiety, and depression. 

This test helps customize treatments to balance cortisol levels throughout the day, optimizing the hypothalamic-pituitary-adrenal axis and improving overall health. 

The test also evaluates DHEA and sIgA, offering additional information on hormone balance and mucosal immune function.

Specialized Panels for Oxidative Stress and Hormonal Health

Precision Point’s Advanced Oxidative Stress profile uses urine and whole blood to assess an individual’s oxidative/reductive balance. 

This test evaluates the level of oxidative stress in the body and the efficiency of antioxidant enzymes in combating it.  It measures % Reduced glutathione, oxidized glutathione, total glutathione, 8-OHdG (a marker of mitochondrial and nuclear damage), and F2-Isoprostane (a marker linked to dementia and cardiovascular disease risk).

Oxidative stress, caused by reactive oxygen species (ROS), can contribute to various health issues including heart disease, neurological conditions, cancers, and toxicity.  This test may benefit patients with neurologic conditions, toxicity, autoimmunity, digestive symptoms, headache, cardiovascular disease, depression, anxiety, or any condition exacerbated by oxidative stress.

Functional Wellness Panels

The Female and Male Functional Wellness Panels offer comprehensive assessments using plasma and serum to track patient well-being and support journeys toward optimal health.  These panels provide clinicians with high-quality, actionable clinical information for a thorough analysis of blood chemistry, hormones, heart disease, metabolic syndrome, and key nutritional markers.

The Female and Male Functional Wellness Panels include a CBC, Chemistry Screen, hormone profile, thyroid panel, and nutritional markers like Vitamin D, folate, and B12. 

The Female Panel includes female hormones such as estradiol (E2), testosterone, progesterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), and DHEA, along with markers for thyroid function and sex hormone binding globulin.  

The Male Panel includes total testosterone, total estrogen, and DHEA, as well as prostate health markers, prostatic specific antigen (PSA) and % free PSA. 


The Gut and Detox Assessment Profile (G-DAP) is a multifaceted test that screens for markers related to gut health, detoxification, and potential risks for major diseases, providing a quick overview of a patient's health status. 

This profile is designed for functional medicine practitioners to screen for common root causes of disease.  

It includes markers such as Zonulin, DAO, Histamine, LPS IgG, IgA, IgM, 8-OHdG, % Reduced Glutathione, Total Glutathione, F2 Isoprostane, Oxidized LDL, HgA1c, hsCRP, and Vitamin D, which are important for assessing leaky gut, detoxification, cardiovascular disease, cancer prevention, and dementia risk. 

Comprehensive List of Test Panels

Allergy and Sensitivity

P88-DIY Dietary Antigen Test (Blood Spot)

P88 Dietary Antigen Test (Serum)

P88-DIY IgG/C3d (Blood Spot)

P88 IgG/C3d (Serum)

Precision Airborne Allergy (Serum) 


Advanced Intestinal Barrier Assessment (Plasma)

G-DAP – Gut & Detox Assessment Profile (Whole Blood, Urine, Serum, Plasma)


Advanced Oxidative Stress Test (Whole Blood, Urine)

Oxidized LDL with Lipids (Serum)

Oxidized LDL (Serum)

Medical Wellness

Male Functional Wellness Panel (Serum, Whole Blood)

Female Functional Wellness Panel (Serum, Whole Blood)

Comprehensive Screen w/Thyroid (Serum, Whole Blood)


Advanced Adrenal Stress Test (Saliva)

Comprehensive Thyroid Panel w/Antibodies (Serum)

Comprehensive Thyroid Panel w/Antibodies & Reverse T3 (Serum)

Male Hormone Panel (Serum)

Female Hormone Panel (Serum)

About the Lab

Precision Point Diagnostics specializes in Functional Diagnostics with a focus on Allergy, Sensitivity, and Intestinal Permeability testing.

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Quality Control Process

3 - 5 days
Shipment Tracking
Provides Tracking Number
Does Not Provide Tracking Number
Avg. Sample Processing
28 days
Consultation Availability
CLIA Certified
CAP Accredited
ISO 15189
COLA Accredited
Order, track, and receive results from 30+ labs in one place.