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Reference Guide
Cyrex Laboratories

Cyrex Laboratories

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Cyrex Laboratories
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About the Lab

Cyrex Laboratories specializes in functional immunology and autoimmunity. Dedicated to the early detection and monitoring of complex autoimmune disorders, Cyrex leverages multi-tissue antibody testing technologies. 

Through ongoing partnerships with prominent medical researchers and clinicians, Cyrex continually develops innovative testing arrays.

About Cyrex Laboratories

Cyrex Laboratories is particularly known for its innovative approaches in diagnosing autoimmune disorders and food sensitivities, providing significant contributions to personalized medicine and health diagnostics.

Cyrex Laboratories Background and History

Cyrex Laboratories was established in 2011 by a group of medical and research professionals aiming to implement diagnostic laboratory testing necessary to meet the needs of today's patients and healthcare complexities.

They are headquartered in Phoenix, Arizona.  

Clinical Focus of Cyrex Laboratories

Cyrex Laboratories is a cutting-edge clinical laboratory with a focus on mucosal, cellular, and humoral immunology. It specializes in developing antibody arrays that target complex thyroid disorders, gluten sensitivities, food-associated autoimmunities, and related neurological dysfunctions. 

Supported by a Scientific Advisory Board that includes experts from diverse medical and research fields, Cyrex integrates the latest medical research with contemporary clinical needs. 

This collaboration fuels the development of innovative lab tests tailored to diagnose and manage today’s intricate health issues and promote deeper understanding in healthcare diagnostics.

Quality Control Measures

At the core of Cyrex Laboratory’s operations is their proprietary Double Assurance System (QC2™), a quality control criterion uniquely designed by Cyrex. This rigorous system enhances the reproducibility, specificity, and sensitivity of all Cyrex testing arrays, ensuring unmatched accuracy. 

Cyrex is the only laboratory that incorporates these enhancements through the QC2™ method, providing an additional layer of reliability to their diagnostic tests.

Advanced Practitioner Support

Cyrex Laboratories offers extensive support to its healthcare practitioner clients. Practitioners can access the latest and most relevant clinical information through a range of professionally accredited educational formats including classes, lectures, webinars, and published articles. 

Additionally, Cyrex sponsors public lectures that provide insights into the latest advancements in healthcare and the new assessment options available through laboratory testing, further supporting healthcare professionals in their ongoing development.

Clinical consultations are available to ordering providers to discuss test results.  

Popular Tests Offered by Cyrex Laboratories

Cyrex Laboratories offers a diverse range of specialized tests that cater to various aspects of autoimmune disorders, food sensitivities, and overall health monitoring. These tests are designed to help healthcare providers and patients better understand complex symptoms and conditions, leading to more effective treatment plans.

Array 2 Intestinal Antigenic Permeability Screen

The Array 2 Intestinal Antigenic Permeability Screen™ is an important initial screening test for patients with multiple chronic GI and neurologic symptoms, suspected food sensitivities, chemical intolerances, or a history of pathogen-induced autoimmune conditions. 

Array 2 differentiates transcellular versus paracellular intestinal permeability, epithelial barrier dysfunction by assessing levels of anti-actomyosin antibodies, anti-zonulin/occludin antibodies, and immune reactivity to lipopolysaccharides (LPS). 

These types of immune reactivity can lead to imbalances of the gut-brain axis and disruption of the blood-brain barrier.

Clinically this test can measure intestinal permeability to large molecules which inflame the immune system and identify the damaging route through the intestinal barrier.

It is recommended for patients who present with multiple symptom complaints and/or suffer from abnormal immune cell count and function (including autoimmune diseases and multiple food sensitivities), without diagnosis or relief.  

Array 3X Wheat/Gluten Proteome Reactivity & Autoimmunity Screen

Array 3X, or the Wheat/Gluten Proteome Reactivity & Autoimmunity Screen, aids in the detection of wheat reactivity, non-celiac gluten sensitivity, celiac disease, and related intestinal barrier damage. It also explores wheat-associated autoimmunity, providing a comprehensive overview of how gluten may be affecting a patient's immune system and gut health.

This test evaluates the body’s reactions to specific protein fragments of gluten, helping to identify sensitivities and conditions such as wheat reactivity, non-celiac gluten sensitivity, Celiac disease, food opioid reactivity, intestinal barrier damage, and wheat-related autoimmunity.

Designed for patients who may not test positive in standard celiac assessments yet exhibit symptoms suggestive of gluten sensitivity, the Array 3X is particularly useful. It benefits those with persistent gastrointestinal symptoms as well as individuals experiencing multi-symptom health issues like chronic fatigue syndrome, fibromyalgia, depression, or neuro-autoimmune disorders. 

Array 4 Gluten-Associated Cross-Reactive Foods & Foods Sensitivity Screen

The Array 4, known as the Gluten-Associated Cross-Reactive Foods & Foods Sensitivity Screen, is tailored to identify immune reactions to foods that may cross-react with gliadin, as well as those newly introduced into a gluten-free diet. 

This test not only assesses an individual’s immune response to gluten but also examines sensitivity to other dietary proteins that may cause similar reactions. Importantly, it identifies foods that cross-react with gluten, helping pinpoint additional dietary triggers that could be contributing to symptoms like bloating, diarrhea, and constipation. 

This is especially useful for individuals with conditions like Celiac Disease or Non-Celiac Gluten Sensitivity (NCGS) who may continue to experience symptoms despite following a gluten-free diet.

Array 12 Pathogen-Associated Immune Reactivity Screen

The Array 12, the Pathogen-Associated Immune Reactivity Screen, detects immune reactions to key pathogens that could contribute to multiple autoimmune reactivities. It is also used to monitor the effectiveness of treatment protocols aimed at addressing autoimmune-related pathogens, making it a valuable tool for both diagnosis and ongoing management of autoimmune conditions.

The Array 12 is particularly valuable for patients presenting with complex autoimmune symptoms that are difficult to diagnose or treat. It uncovers pathogen-induced sensitivities and is highly beneficial in cases where traditional approaches to autoimmunity have been inconclusive or ineffective.

Clinically, this test is used to detect immune reactions to critical pathogens that could lead to multiple autoimmune conditions, determine the involvement of these pathogens in 'unexplained' autoimmune reactions, and gauge the success of therapeutic interventions. 

It is recommended for patients experiencing chronic symptoms such as gastrointestinal distress, fatigue, body aches, or generalized inflammation, including neuroinflammation, especially those who may have been exposed to bacteria, viruses, parasites, molds, and spirochetes linked to autoimmunity, and who have not responded well to standard detoxification and dietary changes.

Array 10 Multiple Food Immune Reactivity Screen

The Array 10 – Multiple Food Immune Reactivity Screen evaluates immune reactions to 180 different foods, including raw and modified foods, food enzymes, lectins, and artificial food additives such as meat glue, colorings, and gums. This extensive screening is vital for detecting dietary-related triggers of autoimmune reactivity and customizing dietary protocols to improve patient health outcomes.

The Array 10 specifically measures the immune system's reactions to a wide array of food antigens, prepared in various ways, providing insights into how different foods may influence immune activity. 

This test is particularly beneficial for patients who are developing a long-term health and wellness strategy and those with unexplained symptoms, whether gastrointestinal, neurological, dermatological, or behavioral. 

It is also recommended for individuals suspected of having increased intestinal permeability, a condition that can facilitate environmentally-induced autoimmune disorders.

Additional Specialized Tests

Cyrex also offers several other specialized tests such as the Lymphocyte MAP, which provides an in-depth analysis of the immune system's functionality and integrity at the cellular level, and the Alzheimer’s LINX, which investigates Alzheimer's-associated immune reactivity and identifies patients at a greater risk of developing Alzheimer's disease or other neurological disorders.   

Complete List of Cyrex Laboratories Test Panels


About the Lab

Cyrex specializes in functional immunology and autoimmunity, and they offer serum antibody testing.

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Quality Control Process

3 - 5 days
Shipment Tracking
Provides Tracking Number
Does Not Provide Tracking Number
Avg. Sample Processing
14 days
Consultation Availability
CLIA Certified
CAP Accredited
ISO 15189
COLA Accredited
Order, track, and receive results from 30+ labs in one place.