Hepatitis B Core Antibody, Total, with Reflex to IgM - This assay detects presence of both IgG and IgM antibodies to the hepatitis B core (anti-HBc) antigen. If positive, it reflexes to further detect only the presence of IgM anti-HBc. When both the total anti-HBc and IgM anti-HBc are positive, it is indicative of acute HBV infection. A positive total anti-HBc with negative IgM anti-HBc is indicative of either acute or past Hepatitis B infection. Total anti-HBc may be the only HBV marker detected in past infection. Anti-HBc antibodies, both total and IgM, are absent from HBV vaccinated people.
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