Lyme Disease Antibody with Reflex to Immunoassay (IgG, IgM) - Lyme disease is a growing health issue. There has been an urgency to establish an efficient testing protocol that increases sensitivity for antibodies against Borrelia burgdorferi in early disease without negatively impacting specificity. In this algorithm, serum is first tested in an immunoassay measuring combined IgG and IgM antibodies to specific borrelial proteins; if reactive, the sample is then tested in separate Borrelia burgdorferi IgG and IgM immunoassays. This algorithm may be able to assist in the identification of early Lyme disease within the first 30 days of infection.
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