Plasminogen Activity - Decreased plasminogen activity may be inherited or acquired. Acquired deficiencies may occur with: tranexamic acid and L-asparginase use, disseminated intravascular coagulation (DIC), liver disease, during and after thrombolytic therapy, sepsis, and hyperthyroidism. Plasminogen activity is developmentally regulated reaching adult levels at approximately 6 months of age. As a positive acute phase reactant, increased levels are associated with infection, trauma, surgery, inflammation and malignancy.
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