Protein S Activity, Antigen, Total and Free - Protein S deficiency may either be hereditary or acquired and is associated with an increased risk for venous thromboembolic disease. Congenital Protein S (PS) deficiency may be classified based on the PS Antigen (Free and Total) and activity results. Type I deficiency is characterized by a decrease in antigen and activity levels whereas a Type II deficiency will have normal antigen levels but reduced activity. A third classification, Type III deficiency, is characterized by reduced free PS antigen and activity, but normal total PS antigen levels associated with increased C4b binding protein level.
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