Anti-tTG IgG

Anti-tTG IgG

What's

Anti-tTG IgG

Anti-tTG IgG, or Anti-Tissue Transglutaminase IgG, is a type of antibody that your immune system might create. It's connected to your body's reaction to a specific protein called 'transglutaminase', which is crucial for keeping your tissues strong and healthy. The presence of Anti-tTG IgG can be linked to how your body responds to certain foods, especially gluten, a protein found in wheat, barley, and rye. Medical professionals often check for this antibody when looking into food sensitivities or particular autoimmune conditions.

If Your Levels Are High

Having higher than normal levels of Anti-tTG IgG might mean that your body is reacting to gluten in your diet. This could be a sign that you have a sensitivity or intolerance to gluten, like non-celiac gluten sensitivity or even celiac disease, which is when your body mistakenly attacks its own tissues because of gluten. It's also possible that other things, like certain medications (such as interferon or immunosuppressants) or infections, could cause your immune system to make more of these antibodies. This increased response might lead to inflammation and harm in different parts of your body.

Symptoms of High Levels

Symptoms of high levels of Anti-tTG IgG could include digestive issues like bloating, diarrhea, or constipation, fatigue, weight loss, and skin rashes. Some people may also experience joint pain, iron deficiency anemia, or neurological problems such as headaches and balance issues.

If Your Levels are Low

Low levels of Anti-tTG IgG might mean that your body isn't reacting negatively to gluten in your diet. In other words, your immune system may not see gluten as a problem, so it doesn't make these specific antibodies. It's also possible that your body just naturally produces a smaller amount of Anti-tTG IgG. Things like your overall health, age, and other medical conditions could affect these levels. However, it's important to remember that low levels of Anti-tTG IgG don't necessarily mean you don't have food sensitivities or autoimmune issues, as other factors and markers can also play a role.

Symptoms of Low Levels

Symptoms of low levels of Anti-tTG IgG are typically absent, as this condition often does not present any noticeable signs or discomfort.

See References

Test for

Celiac Disease Evaluation by Access Med Labs

Serum

This test provides a comprehensive evaluation of the antibodies that are characteristic of celiac disease. Celiac disease is also associated with selective IgA deficiency and autoimmune disorders.

Celiac Profile by Genova Diagnostics

Serum

The Celiac Profile is a comprehensive serologic profile that uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease and gluten sensitivity.

Full Immunology Panel by Genova Diagnostics

Serum

The Full Immunology Panel assesses food and inhalant allergies and sensitivities by combining the following panels: IgE Food Antibodies, IgE Inhalants, IgE Molds, IgG Food Antibodies, IgG Spices, IgG Vegetarian, and Celiac Profile.

Tissue Transglutaminase IgG by Access Med Labs

Serum

This is a single-marker test measuring IgG antibodies to tissue transglutaminase. It is used to aid in the diagnosis of gluten-sensitive enteropathies such as celiac disease.

Gut IQ by US BioTek

Stool

The Gut IQ Profile is a comprehensive stool analysis providing a broad view of overall gut health by combining PCR and genomic sequencing technologies. Metagenomic sequencing analyzes the genetic material of entire microbial communities in a stool sample. This technique, known as shotgun sequencing, randomly and unbiasedly sequences all genetic material, covering over 28,000 microbial species. Unlike targeted approaches, it offers a comprehensive view, revealing previously unknown or unculturable microorganisms. From a simple stool sample, it provides detailed information on the microbiome and biochemical markers related to digestion, inflammation, and intestinal permeability.

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