The Celiac Profile is a comprehensive serologic profile that uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease and gluten sensitivity.
The following markers are included in this profile:
IgA and IgG Antibodies against Deamidated Gliadin Peptides: These antibodies against partially broken-down gliadin molecules that stimulate a T cell antibody response in susceptible
Anti-DGP IgA
Anti-DGP IgG
IgA and IgG Anti-Tissue Transglutaminase Antibodies: antibodies against the anti-tissue transglutaminase enzyme which is released in response to inflammation
Anti-tTG IgA
Anti-tTG IgG
Total IgA
Anti-EMA IgA (IgA Anti-Endomysial Antibodies)
This panel includes serum antibodies against groups of antibodies that have been shown to have a high clinical correlation with the diagnosis of celiac disease. [1., 2.]
Compared to the gold standard for diagnosis of celiac disease, an intestinal biopsy and pathology, this serum test is a much less invasive and still highly-specific and sensitive alternative to understanding whether a patient suffering with digestive and exta-intestinal manifestations may be living with celiac disease. [1., 2.]
A variety of individuals may benefit from the Celiac Profile by Genova Diagnostics:
Individuals experiencing symptoms such as gastrointestinal discomfort including gas, bloating, loose stool
People with malabsorption issues and/or unexplained nutrient deficiencies
Individuals with a family history of celiac disease
People with autoimmune conditions
Patients with Hashimoto’s thyroiditis, especially those with an increased need for T4 due to malabsorption [3.]
People suspected of having celiac disease, who want to avoid a biopsy procedure
For a complete list of collection instructions, click here.
Article: How to Interpret Your Celiac Blood Test Results
[1.] Jafari SA, Alami A, Sedghi N, Kianifar H, Kiani MA, Khalesi M, Derafshi R. Diagnostic accuracy of anti-DGP (IgG) for celiac disease. J Family Med Prim Care. 2023 Jan;12(1):42-46. doi: 10.4103/jfmpc.jfmpc_326_22. Epub 2023 Feb 15. PMID: 37025242; PMCID: PMC10071923.
[2.] Ortiz G, Messere G, Toca MDC, Fiorucci M, Bigliardi R, Vidal J, Reynoso R. IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. Arch Argent Pediatr. 2019 Feb 1;117(1):52-55. English, Spanish. doi: 10.5546/aap.2019.eng.52. PMID: 30652447.
[3.] Sedhom R, Katz K. Celiac Disease and Treatment of Hypothyroidism: An Unappreciated Problem: 2049. Official journal of the American College of Gastroenterology | ACG. 2016;111:S978. Accessed February 20, 2024. https://journals.lww.com/ajg/fulltext/2016/10001/celiac_disease_and_treatment_of_hypothyroidism__an.2049.aspx#:~:text=There%20is%20evidence%20demonstrating%20a
The Celiac Profile is a comprehensive serologic profile that uses widely accepted immunologic biomarkers to aid in the diagnosis of Celiac disease and gluten sensitivity.
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