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Reference Guide
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8-OHdG
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8-OHdG
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8-Hydroxy-2-deoxyguanosine

What's 
8-OHdG
?
8-Hydroxy-2-deoxyguanosine, often abbreviated as 8-OHdG, is a compound that occurs naturally in your body. It's a byproduct of a process called oxidative stress, which happens when your body uses oxygen to create energy. Think of it like the exhaust that comes out of a car after it burns gasoline. 8-OHdG is particularly interesting because it's linked to your DNA - the blueprint of life that's found in every cell of your body. When oxidative stress occurs, 8-OHdG can be formed directly in your DNA. Scientists often measure the levels of 8-OHdG to understand how much oxidative stress a person's body is undergoing. In a nutshell, 8-OHdG is like a biological smoke detector. It doesn't cause the fire, but its presence can tell us that something is burning.
If Your Levels Are High
High levels of 8-Hydroxy-2-deoxyguanosine, or 8-OHdG, in your body could indicate that your body is experiencing a high level of oxidative stress. Oxidative stress is like a car engine running hot; it's a natural process where your body uses oxygen to produce energy, but it can also produce 'exhaust' in the form of 8-OHdG. This compound is directly linked to your DNA, the blueprint of life in every cell. So, if you have high levels of 8-OHdG, it's like a smoke alarm going off, signaling that your body's 'engine' is running hot. This could be due to a variety of factors, such as exposure to environmental toxins, certain medications like chemotherapy drugs, or health conditions like diabetes or heart disease. It's not the 8-OHdG causing the problem, but its presence can indicate that something else is putting stress on your body.
Symptoms of High Levels
Symptoms of high levels of 8-Hydroxy-2-deoxyguanosine are not specific, as it is a marker of oxidative stress rather than a disease itself. However, it could be associated with symptoms related to the underlying cause of the oxidative stress, such as fatigue, weakness, or other symptoms related to conditions like diabetes or heart disease.
If Your Levels are Low
8-OHdG is a substance that your body makes when it uses oxygen to produce energy, similar to how a car produces exhaust when it burns fuel. This substance is connected to your DNA, the instruction manual for all the cells in your body. When your body is under stress from things like poor diet, lack of sleep, or certain medications like chemotherapy drugs, it can produce more 8-OHdG. Scientists often check how much 8-OHdG is in your body to see how much stress your body is under. If your levels are low, it could mean that your body isn't under a lot of stress, or that it's effectively managing the stress it's under.
Symptoms of Low Levels
Symptoms of low levels of 8-Hydroxy-2-deoxyguanosine may not be easily noticeable as this substance is more of an indicator of oxidative stress rather than a cause of specific symptoms.

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8-Hydroxy-2-deoxyguanosine

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