Zonulin is a glycoprotein that plays an important role in the regulation of tight junctions between cells, which helps maintain proper permeability and integrity of epithelial and endothelial cell layers. Elevated zonulin levels are associated with increased intestinal permeability or "leaky gut," which can lead to inflammation-related illnesses such as allergies, autoimmune diseases, metabolic syndrome, and gastrointestinal disorders.
If Your Levels Are High
Symptoms of High Levels
If Your Levels are Low
Symptoms of Low Levels
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The GI-MAP is a comprehensive stool test that utilizes qPCR technology to detect parasites, bacteria, fungi, and more, allowing practitioners to create personalized treatment protocols to address gut dysfunction. This test also includes an add-on for the leaky gut marker zonulin.
Add-On: Zonulin by Genova Diagnostics
Stool
This is a single-marker test measuring zonulin. It is available as an add-on to the GI Effects® profiles.
Zonulin Add-On by Diagnostic Solutions
Stool
This add-on test measures zonulin, a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It is used to help diagnose intestinal permeability/leaky gut and can be ordered as an add-on to the GI-MAP.
FIT 176 + Gut Barrier Panel by KBMO Diagnostics
Blood Spot
The FIT 176 test evaluates sensitivities to 176 foods and additives by measuring IgG antibodies and immune complexes. It now includes the Gut Barrier Panel, with markers such as IgG 1-4/C3d and IgA 1-2. This version of the test is conducted using a blood spot sample, but it is also available as a serum test.
FIT 132 + Gut Barrier Panel by KBMO Diagnostics
Blood Spot
The FIT 132 test evaluates sensitivities to 132 foods and additives by measuring IgG antibodies and immune complexes. It now includes the Gut Barrier Panel, with markers such as IgG 1-4/C3d and IgA 1-2. This version of the test is conducted using a blood spot sample, but it is also available as a serum test.