The TruAge PACE test by TruDiagnostics offers a comprehensive assessment of biological aging by focusing on short-term methylation changes that have long-term implications for health. Unlike traditional chronological age assessments, this innovative test delves into cellular aging, providing insights into how lifestyle, environmental factors, and medical interventions impact the aging process.
The TruAge PACE test by TruDiagnostics uses the exclusively-licensed DunedinPACE algorithm to calculate your current speed of aging. Renowned for its unique approach to aging assessment based on health-related phenotypes and variables rather than just chronological age, this test demonstrates an individual’s speed of aging.
By analyzing cellular aging on a molecular level, the TruAge PACE test empowers individuals to track the effectiveness of recent interventions and gain a deeper understanding of their body's aging trajectory.
The TruAge PACE kit is ideal for individuals passionate about anti-aging, providing a means to monitor the effectiveness of recent lifestyle, environmental, and medical interventions. It is commonly employed following a comprehensive understanding of the baseline and specific age-related measurements offered by the TruAge COMPLETE kit.
Biological age encapsulates the physiological state of an individual's body, reflecting the cumulative impact of lifestyle, genetics, and environmental factors on aging processes. Unlike chronological age, which remains constant, biological age can vary significantly among individuals of the same age group. [2., 10.] This discrepancy underscores the importance of personalized age assessment to tailor interventions and mitigate age-related health risks effectively.
The TruAge PACE by TruDiagnostic offers an assessment of biological age based on short-term methylation changes and telomere length to demonstrate an individual’s biological, or cellular, age.
Assessing biological age involves a multifaceted approach encompassing various biomarkers that collectively reflect the physiological state of an individual's body and the processes underlying aging. Telomere length, one such biomarker, is indicative of cellular aging and overall health. Telomeres, the protective caps at the ends of chromosomes, undergo progressive shortening with each cell division. Studies have demonstrated a correlation between shortened telomeres and accelerated aging, as well as an increased risk of age-related diseases. A number of lifestyle factors may be responsible for telomere shortening. [5., 6.]
DNA methylation patterns, reflecting epigenetic modifications, are informative biomarkers for biological age. Changes in DNA methylation status are associated with aging and age-related diseases, and increasingly show potential in age-related health assessment. [8.]
Results for the DunedinPACE test are presented in a numerical value, with anything below 1 meaning that for every calendar year, the individual tested ages less than 1 calendar year, or has slower biological aging. Any result above 1 means that for every calendar year the individual is aging faster than 1 year, or has accelerated aging, which ia significantly associated with greater risk of death and chronic disease. [3.]
These biomarkers provide an assessment of biological age, enabling personalized interventions aimed at promoting healthy aging and enhancing overall well-being.
At the heart of the DunedinPACE Report lies the Dunedin Study, a longitudinal research endeavor that has significantly contributed to our understanding of aging processes and their impact on health outcomes. Initiated in 1972 in Dunedin, New Zealand, the ongoing Dunedin Study has followed a cohort of over 1,000 individuals from birth to adulthood, meticulously documenting various aspects of their physical health, psychological well-being, and social functioning. [11.]
The Pace of Aging report uses the DunedinPACE algorithm to calculate current speed of aging.
The TruAge PACE by TruDiagnostic is recommended for individuals who are interested in gaining a comprehensive understanding of their biological age and overall health status, and monitoring changes in cellular health and aging due to changes in diet and lifestyle.
This test is particularly beneficial for:
Individuals interested in optimizing their healthspan and longevity: The TruAge Complete Collection sheds insights into various aspects of biological aging, empowering individuals to adopt proactive measures to promote healthy aging and enhance overall well-being.
Those concerned about age-related health risks: By assessing biomarkers associated with aging processes, such as telomere length, epigenetic markers, and physiological parameters, the TruAge Complete Collection enables individuals to identify potential health risks and implement targeted interventions to mitigate them.
Individuals seeking personalized health recommendations: Based on the findings of the age assessment and health risk profiling, the TruAge Complete Collection generates personalized health recommendations tailored to individual needs and preferences, guiding individuals towards lifestyle modifications, dietary interventions, and preventive healthcare measures.
Individuals with a personal or family history of cardiometabolic disease or cognitive decline: These individuals may benefit from undergoing the TruAge Complete Collection test by TruDiagnostic. Given the comprehensive nature of this test, it can provide valuable insights into various biomarkers associated with aging and age-related health risks, including those related to cardiometabolic health and cognitive function. [1., 4.]
Healthcare professionals and researchers: The TruAge Complete Collection offers data for healthcare professionals and researchers studying aging processes, age-related diseases, and interventions aimed at promoting healthy aging. By leveraging the insights provided by the TruAge Complete Collection, healthcare professionals can develop personalized treatment plans and researchers can advance our understanding of aging and age-related health outcomes.
Overall, the TruAge Complete Collection is suitable for individuals of all ages who are interested in proactively managing their health, optimizing their aging trajectory, and enhancing their quality of life.
Prepare: Hydrate for 24 hours before collecting your sample. Continue taking medications and supplements as usual.
Registration: Visit www.trudiagnostic.com/register or scan the QR code on your kit to complete online registration.
Collection:
a. Clean a finger with the provided alcohol wipe.
b. Use the lancet to prick your finger and collect drops of blood on the designated circles on the card.
c. Ensure blood saturates the card and air dry for at least 3 hours.
Packaging:
a. Place the dried card into the biohazard bag.
b. Seal the bag and place it in the return envelope.
Shipping: Ship the sample via USPS the same day if possible or refrigerate until shipping.
Results: Results are typically available to your provider 2-3 weeks after the lab receives your sample.
Remember, registration is required for analysis, and ensure prompt shipping of your sample for accurate results.
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[2.] Belsky DW, Caspi A, Houts R, et al. Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences. 2015;112(30):E4104-E4110. doi:https://doi.org/10.1073/pnas.1506264112
[3.] Belsky DW, Caspi A, Arseneault L, et al. Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. Hagg S, Tyler JK, Hagg S, Justice J, Suderman M, eds. eLife. 2020;9:e54870. doi:https://doi.org/10.7554/eLife.54870
[4.] Currais A, Goldberg J, Farrokhi C, Chang M, Prior M, Dargusch R, Daugherty D, Armando A, Quehenberger O, Maher P, Schubert D. A comprehensive multiomics approach toward understanding the relationship between aging and dementia. Aging (Albany NY). 2015 Nov;7(11):937-55. doi: 10.18632/aging.100838. PMID: 26564964; PMCID: PMC4694064.
[5.] Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5. doi: 10.1073/pnas.0407162101. Epub 2004 Dec 1. PMID: 15574496; PMCID: PMC534658.
[6.] Epel ES, Merkin SS, Cawthon R, et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration. Aging. 2008;1(1):81-88. doi:https://doi.org/10.18632/aging.100007
[7.] Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007 Jan;128(1):92-105. doi: 10.1016/j.mad.2006.11.016. Epub 2006 Nov 20. PMID: 17116321.
[8.] Horvath S. DNA methylation age of human tissues and cell types. Genome biology. 2013;14(10):R115. doi:https://doi.org/10.1186/gb-2013-14-10-r115
[9.] Johnson LC, Parker K, Aguirre BF, Nemkov TG, D'Alessandro A, Johnson SA, Seals DR, Martens CR. The plasma metabolome as a predictor of biological aging in humans. Geroscience. 2019 Dec;41(6):895-906. doi: 10.1007/s11357-019-00123-w. Epub 2019 Nov 9. PMID: 31707594; PMCID: PMC6925078.
[10.] Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573-591. doi:https://doi.org/10.18632/aging.101414
[11.] Poulton R, Moffitt TE, Silva PA. The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future. Soc Psychiatry Psychiatr Epidemiol. 2015 May;50(5):679-93. doi: 10.1007/s00127-015-1048-8. Epub 2015 Apr 3. PMID: 25835958; PMCID: PMC4412685.
[12.] Wikby A, Strindhall J, Johansson B. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies. Springer eBooks. Published online January 1, 2009:3-28. doi:https://doi.org/10.1007/978-1-4020-9063-9_1
The TruAge PACE is a biological pace of aging test that focuses on short-term changes in methylation that translate into long-term impacts on health. It includes Dunedin PACE, the only publicly available aging algorithm trained on phenotypes and variables of health rather than chronological age.
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