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Hacking GLP-1 Through the Gut Microbiome
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About this class

Increasing knowledge of the gut microbiome has revealed that Akkermansia and a bacterial strain that produces butyrate can augment GLP-1 production through natural stimulation of the L-cells. In this live class, we learn from Dr. Colleen Cutcliffe, Ph.D and Dr. Adam Perlman, MD, experts on GLP-1 and the gut microbiome.

Understanding GLP-1's Role in Metabolic Health: GLP-1 influences pancreatic insulin release, affects glucagon levels, impacts appetite and satiety, and is linked to metabolic health. It is produced in the gut, and its release can be stimulated by eating, with signals mediated by the microbiome.

Impact of the Microbiome on GLP-1: The microbiome, particularly specific strains of bacteria, plays a crucial role in the regulation of GLP-1. Enhancing the microbiome's health can improve GLP-1 regulation and, by extension, metabolic health.

Incorporating Probiotics 2.0: Consider using advanced probiotic formulations that target the microbiome to improve GLP-1 regulation. These probiotics may include specific strains like Akkermansia muciniphila, known for its beneficial effects on the gut barrier and metabolic functions.

Dietary Fibers and Polyphenols: Incorporate dietary fibers and polyphenols into the diet, as they can influence beneficial strains of bacteria in the gut, supporting metabolic health and potentially stimulating GLP-1.

Natural Approaches to Stimulate GLP-1: Before considering pharmacological GLP-1 mimetics, explore natural ways to support metabolic health through the microbiome, such as targeted probiotics, dietary changes, and lifestyle interventions.

Monitoring and Adjusting Treatment Based on Microbiome Analysis: Consider testing for specific strains of bacteria in the gut, such as Akkermansia muciniphila, to tailor treatments and dietary recommendations for improving metabolic health.

Educational Resources: For healthcare providers, utilize resources like for further information on microbiome health, probiotics, and dietary recommendations.

Product Consideration: In cases of metabolic dysfunction or signs of gut barrier dysfunction, products like Pendulum Glucose Control, which contains targeted probiotic strains, might be beneficial as part of a comprehensive treatment plan.

Encouraging Lifestyle Changes: Alongside probiotic supplementation, emphasize the importance of a healthy diet rich in fibers and polyphenols, physical activity, and other lifestyle factors that contribute to a healthy microbiome and metabolic health.

These actionable items highlight the importance of the microbiome in metabolic health and offer a framework for incorporating this knowledge into clinical practice, focusing on natural and preventative measures.

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