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Reference Guide
Diagnostic Solutions


Diagnostic Solutions
Diagnostic Solutions
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About the Test

The Zonulin Profile from Diagnostic Solutions Laboratory is a specific diagnostic test designed to measure the levels of zonulin in the body. Zonulin is a protein that regulates the permeability of the tight junctions between cells in the digestive tract. The primary role of zonulin is to control the flow of molecules, including nutrients and antigens, between the bloodstream and the intestinal lumen.

Key Aspects of the Zonulin Profile Test

Purpose of the Test: The Zonulin Profile is used to assess the integrity of the gut barrier. Elevated levels of zonulin can indicate increased intestinal permeability, often referred to as "leaky gut syndrome." This condition allows substances that are normally confined to the digestive tract to pass into the bloodstream, which can lead to various health issues.

Clinical Significance: Increased intestinal permeability has been associated with several conditions, including autoimmune diseases, inflammatory bowel disease (IBD), celiac disease, type 1 diabetes, and other disorders related to the immune system. Measuring zonulin levels can aid in the diagnosis and management of these conditions.

Test Methodology: While specific details about the methodology used by Diagnostic Solutions Laboratory may not be available, zonulin levels are typically measured through blood tests or stool samples. Diagnostic Solutions Laboratory uses stool sampling, and Zonulin can be “added on” to their GI-MAP.

Application in Clinical Practice: The test can be particularly useful for practitioners in identifying patients who may benefit from interventions aimed at restoring gut barrier integrity. It can also be an important tool in a broader diagnostic approach to understanding the root causes of gastrointestinal symptoms and systemic health issues.

The Zonulin Profile from Diagnostic Solutions Laboratory is a valuable diagnostic tool for evaluating gut permeability and its potential contributions to a wide range of health conditions. By measuring zonulin levels, healthcare providers can gain insights into the integrity of the gut barrier, which is a crucial aspect of gastrointestinal and systemic health.

What patients should receive a Zonulin Profile from Diagnostic Solutions Laboratory?

The Zonulin Profile from Diagnostic Solutions Laboratory is particularly beneficial for patients who exhibit symptoms or have conditions that may be associated with increased intestinal permeability, also known as "leaky gut syndrome." Here are the patient groups who are most likely to benefit from a Zonulin Profile test:

Patients with Gastrointestinal Disorders: Individuals experiencing chronic gastrointestinal symptoms such as bloating, diarrhea, constipation, and abdominal pain. These symptoms can sometimes be indicative of increased intestinal permeability.

Patients with Autoimmune Diseases: Autoimmune conditions like rheumatoid arthritis, type 1 diabetes, or multiple sclerosis are often linked with gut health issues. A Zonulin Profile can help assess the gut's role in these diseases.

Individuals with Celiac Disease or Non-Celiac Gluten Sensitivity: For patients with diagnosed celiac disease or those suspected of having non-celiac gluten sensitivity, zonulin testing can provide insights into the extent of gut barrier dysfunction.

Patients with Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis, which are characterized by chronic inflammation of the gut, can be associated with altered gut permeability.

Individuals with Food Allergies or Intolerances: Testing for zonulin levels can be informative for patients who have food allergies or intolerances, as these conditions may be related to the permeability of the gut lining.

Patients with Dermatological Conditions: Skin conditions like eczema or psoriasis, which can sometimes be linked to gut health, may warrant a zonulin test.

Individuals with Chronic Fatigue or Fibromyalgia: These systemic conditions have been associated with gut health, and a Zonulin Profile might provide valuable information regarding gut permeability.

Patients Undergoing Nutritional or Gastrointestinal Treatment: For those already receiving treatment for gastrointestinal issues, zonulin testing can help monitor the effectiveness of dietary interventions, probiotics, or other gut health therapies.

The Zonulin Profile test is a useful diagnostic tool for a wide array of conditions, particularly those related to gut health and immune function. It can aid healthcare practitioners in diagnosing, monitoring, and tailoring treatment strategies for patients with increased intestinal permeability and related health issues.

Collection instructions

To collect a stool sample for a Zonulin lab test from Diagnostic Solutions Laboratory, you will need to follow these steps:

Test Kit Preparation: Ensure you have the correct test kit provided by Diagnostic Solutions Laboratory. This kit should include a collection container, instructions, and materials for returning the sample.

Read the Instructions Carefully: Before collecting the sample, read all instructions included in the test kit thoroughly. These instructions will provide specific details on how to properly collect and handle the stool sample.

Stool Sample Collection:

  • Timing: Collect the stool sample at a time that is convenient for you, but ensure it can be shipped according to the instructions provided.
  • Hygiene: Begin with clean hands and a clean surface.
  • Avoid Contamination: Ensure that the stool does not come into contact with toilet water or urine to prevent contamination.
  • Collection Container: Use the provided container to collect the stool sample. This may involve using a special collection tool or directly collecting into the container.

Sample Size: Collect only the amount of stool requested in the instructions. Too little or too much can affect the test results.

Storage and Handling: Once collected, follow the instructions for storing the sample. This may involve adding a preservative, if provided, and ensuring the sample is kept at the correct temperature.

Labeling and Documentation: Label the sample container as instructed. Fill out any required forms or labels that need to be sent back with the sample.

Return Shipping: Package the sample as directed, usually in the provided biohazard bag and shipping container. Ship the sample back to Diagnostic Solutions Laboratory promptly, according to the provided instructions, to ensure the sample's integrity.

These are general guidelines. Always follow the specific instructions provided with your test kit, as procedures may vary slightly depending on the kit's design and requirements.

About the Test

This stand-alone test measures zonulin, a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It is used to help diagnose intestinal permeability/leaky gut.

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Lab Test Information
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Sample Type
Shipping Time
2 - 3 days
Turnaround Time
14 days
Test Preparation Starts
No test preparation required
Number of Collection Days
1 day
Methods Used For Processing
Lab Certifications
CLIA Certified
CAP Accredited
ISO 15189
COLA Accredited
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