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GI Effects® Comprehensive Profile - 3 day

GI Effects® Comprehensive Profile - 3 day

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Genova Diagnostics
GI Effects® Comprehensive Profile - 3 day
Genova Diagnostics
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About the Test

What is the GI Effects® Comprehensive Test?

The GI Effects® Comprehensive Profile test from Genova Diagnostics is a group of advanced stool tests that assess digestive function, intestinal inflammation, and the intestinal microbiome to assist in managing gastrointestinal health. Gut microorganisms are codependent on one another, and their human host and the health of one affect the other.

This is the 3-day version of this test; it is also available as a 1-day test.

Why Choose 1 Day vs. 3 Day Collection?

The choice of either 1 or 3-day collection is based on the clinician's suspicion of parasitic infection. If low or no suspicion, a one-day sample will likely be adequate. If there is high suspicion, a 3-day sample collection is optimal.

What is the Difference Between the GI Effects Fundamental and GI Effects Comprehensive Test?

Genova Diagnostics has added a level of enhanced clinical utility to GI Effects reporting in the GI Effects Comprehensive Testing. New enhancements make interpretation quicker and easier to prioritize treatment and assess microbiome status.

The report will now synthesize findings by integrating a novel, proprietary scoring system. These Functional Imbalance Scores will help direct targeted therapeutic recommendations with support options included on the front page of the report. Clinicians can prioritize test findings and treatment based on score severity and can track scores over time. Biomarkers are grouped and scored in 5 key areas relating to GI function:

  1. Maldigestion
  2. Inflammation
  3. Dysbiosis
  4. Metabolite Imbalance
  5. Infection

Which Patients is the GI Effects® Comprehensive Test Best Used For?

Extensive scientific research associates an imbalance of the normal gut microbiota or dysbiosis to gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), and wider systemic alterations such as celiac disease, cardiovascular disease, neurological disorders, malnutrition, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders.

The GI Effects Comprehensive Test will report on biomarkers analysis, providing comprehensive information for developing strategic interventions. Symptoms usually improve as identified functional inadequacies and imbalances are normalized through lifestyle, targeted dietary, and supplementation therapeutics.

What Does The GI Effects® Comprehensive Test Measure?

The GI Effects Comprehensive Test can reveal critical information about the root cause of gastrointestinal symptoms such as gas, diarrhea, bloating, indigestion, abdominal pain, and constipation.

Several biomarkers are analyzed to define a diagnosis. For example, fecal calprotectin is studied to differentiate between IBD and IBS. The GI Comprehensive test can be considered to evaluate patients with a clinical history that suggests a gastrointestinal infection or dysbiosis.

The specific biomarkers measured in this test are related to:

Digestion/Absorption:

  • Pancreatic Elastase-1
  • Products of Protein Breakdown
  • Fecal Fat

Inflammation/Immunology:

  • Calprotectin
  • Eosinophil Protein X
  • Fecal Secretory IgA
  • Fecal Occult Blood

Gut Microbiome

  • Metabolic indicators
  • Commensal Bacteria
  • Bacterial and mycology cultures
  • Bacterial and mycology sensitivities
  • Parasitology
  • Campylobacter
  • Clostridium difficile
  • Escherichia coli
  • Helicobacter pylori
  • Fecal Lactoferrin
  • Macro Exam for Worms
  • Zonulin Family Peptide
  • KOH Preparation for Yeast

The GI Effects Comprehensive Test combines a selection of high throughput methodologies for the microbiome study. 16S rRNA gene polymerase chain reaction (PCR) amplification technique for anaerobic commensal bacteria with Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology and standard microscopic ova and parasite detection with Next-Generation DNA sequencing for Blastocystis spp.

The report will provide the results of the biomarkers analyzed, grouped, and scored in 5 key areas relating to GI function: Maldigestion, Inflammation, Dysbiosis, Metabolite Imbalance, and Infection. A positive result on one or more fecal biomarker tests may guide treatment options or may define or eliminate a diagnosis from further consideration.

What Type of Sample is Needed to Complete the GI Effects® Comprehensive Test?

A stool sample collected over three days is required for the test. Stool samples are shipped to the lab for sample analysis.

Genova Diagnostics provides clear information to patients for sample collection. If taking antibiotics, antiparasitics, antifungals, or probiotic supplements, it is recommended that patients wait for a minimum of 14 days after the last dose before commencing the test; 28 days may be preferred after antibiotics treatment.

About the Test

The GI Effects® Comprehensive Profile is a group of advanced stool tests that assess digestive function, intestinal inflammation, and the intestinal microbiome to assist in the management of gastrointestinal health. This is the 3-day version of the test; it is also available as a 1-day test.

More Resources

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Biomarkers

Cryptosporidium spp.
Cryptosporidium spp.
Giardia
Giardia
Bifidobacterium spp.
Bifidobacterium spp.
Lactobacillus spp.
Lactobacillus spp.
Firmicutes/Bacteroidetes Ratio
Firmicutes/Bacteroidetes Ratio
Fusobacterium spp.
Fusobacterium spp.
Klebsiella pneumoniae
Klebsiella pneumoniae
Candida spp.
Candida spp.
Cyclospora cayetanensis
Cyclospora cayetanensis
Dientamoeba fragilis
Dientamoeba fragilis
Endolimax nana
Endolimax nana
Entamoeba coli
Entamoeba coli
Ascaris lumbricoides
Ascaris lumbricoides
Trichuris trichiura
Trichuris trichiura
Secretory IgA
Secretory IgA
Calprotectin
Calprotectin
Beta-Glucuronidase
Beta-Glucuronidase
Acetate %
Acetate %
Akkermansia muciniphila
Akkermansia muciniphila
Anaerotruncus colihominis
Anaerotruncus colihominis
a-Hemolytic Streptococci
a-Hemolytic Streptococci
Bacteroides vulgatus
Bacteroides vulgatus
Bacteroides-Prevotella group
Bacteroides-Prevotella group
Bifidobacterium longum
Bifidobacterium longum
Butyrivibrio crossotus
Butyrivibrio crossotus
Total Cholesterol
Total Cholesterol
Clostridium spp.
Clostridium spp.
Collinsella aerofaciens
Collinsella aerofaciens
Coprococcus eutactus
Coprococcus eutactus
Desulfovibrio piger
Desulfovibrio piger
Escherichia coli
Escherichia coli
Faecalibacterium prausnitzii
Faecalibacterium prausnitzii
Total Fecal Fat
Total Fecal Fat
Occult Blood
Occult Blood
Long Chain Fatty Acids
Long Chain Fatty Acids
Methanobrevibacter smithii
Methanobrevibacter smithii
Capillaria philippinensis
Capillaria philippinensis
Enterobius vermicularis
Enterobius vermicularis
Strongyloides stercoralis
Strongyloides stercoralis
Oxalobacter formigenes
Oxalobacter formigenes
Pancreatic Elastase 1
Pancreatic Elastase 1
Phospholipids
Phospholipids
Total Valerate+Isobutyrate+Isovalerate
Total Valerate+Isobutyrate+Isovalerate
Propionate %
Propionate %
Total Short Chain Fatty Acids
Total Short Chain Fatty Acids
Triglycerides
Triglycerides
Butyrate %
Butyrate %
Butyrate
Butyrate
Diphyllobothrium latum
Diphyllobothrium latum
Dipylidium caninum
Dipylidium caninum
Hymenolepis diminuta
Hymenolepis diminuta
Hymenolepis nana
Hymenolepis nana
Taenia spp.
Taenia spp.
Clonorchis/Opisthorchis spp.
Clonorchis/Opisthorchis spp.
Heterophyes/Metagonimus
Heterophyes/Metagonimus
Paragonimus spp.
Paragonimus spp.
Schistosoma spp.
Schistosoma spp.
Balantidium coli
Balantidium coli
Blastocystis spp.
Blastocystis spp.
Chilomastix mesnili
Chilomastix mesnili
Entamoeba histolytica/dispar
Entamoeba histolytica/dispar
Entamoeba hartmanni
Entamoeba hartmanni
Entamoeba polecki
Entamoeba polecki
Iodamoeba buetschlii
Iodamoeba buetschlii
Cystoisospora spp.
Cystoisospora spp.
Trichomonads
Trichomonads
Cryptosporidium parvum/hominis
Cryptosporidium parvum/hominis
Hookworm
Hookworm
Fasciolopsis buski
Fasciolopsis buski
Fasciola hepatica
Fasciola hepatica
Barnesiella spp.
Barnesiella spp.
Odoribacter spp.
Odoribacter spp.
Prevotella spp.
Prevotella spp.
Pseudoflavonifractor spp.
Pseudoflavonifractor spp.
Roseburia spp.
Roseburia spp.
Ruminococcus spp.
Ruminococcus spp.
Veillonella spp.
Veillonella spp.
Eosinophil Protein X
Eosinophil Protein X
Bacterial Sensitivities
Bacterial Sensitivities
Yeast Sensitivities
Yeast Sensitivities
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Lab Test Information
Price
$
429
.00
 $
429.00
Sign up to View
Sample Type
Stool
Shipping Time
5 - 10 days
FedEx
Turnaround Time
21 days
Test Preparation Starts
Up to 28 days before collection
Number of Collection Days
3 days
Methods Used For Processing
Antibiotic Susceptibility Testing, Automated Chemistry, EIA, FIT, GC-MS, MALDI-TOF MS, Next Generation Sequencing, PCR
Lab Certifications
CLIA Certified
CAP Accredited
ISO 15189
COLA Accredited
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