The Food Allergy and Sensitivity Testing (FAST 88 Foods: IgE, IgG4, IgG, C3b/d) offered by Infinite Allergy Labs is a comprehensive assessment tool designed to identify adverse reactions to a wide range of food antigens.
This test analyzes various immunoglobulins (IgE, IgG4, IgG) as well as complement activation products (C3b/d), providing a thorough assessment of the immune response to 88 common food allergens. By measuring multiple immune markers, including both immediate (IgE) and delayed (IgG, IgG4) hypersensitivity reactions, as well as complement activation, this test offers a comprehensive understanding of the body's immune reactivity to different foods. [18.]
For patients, this test can offer insights into their individual sensitivities and intolerances, helping them identify specific dietary triggers contributing to various health issues such as digestive problems, skin disorders, autoimmune conditions, and chronic inflammation.
Additionally, by pinpointing potential food allergens, patients can make informed dietary modifications to alleviate symptoms and improve overall well-being. For medical providers, the FAST 88 Foods test provides a valuable tool for identifying food sensitivities and allergies, guiding personalized treatment plans, and optimizing patient care.
This comprehensive approach to food allergy testing empowers both patients and healthcare providers to address underlying immune imbalances and promote better health outcomes.
Environmental Allergy Test (88 Antigen IgE) By Infinite Allergy Labs:
The 88 Antigen IgE Environmental Panel by Infinite Allergy Labs provides a comprehensive and less invasive alternative to traditional skin prick allergy testing. Unlike skin prick tests, which can be uncomfortable and expose patients directly to potential allergens, serum allergy testing requires only one blood sample to test multiple allergens.
Infinite Allergy Labs' Environmental Allergy Panel covers 88 common allergens, offering a thorough assessment of environmental triggers that may contribute to allergic reactions. Understanding the distinction between seasonal and perennial allergies is crucial, as seasonal allergies are typically triggered by outdoor allergens like pollen and mold spores, whereas perennial allergies are often caused by indoor allergens such as dust mites, mold, fabrics, and animal dander.
By identifying specific allergens through serum testing, patients and healthcare providers can develop targeted strategies to manage allergic symptoms and improve overall quality of life.
If patients are exhibiting allergy symptoms or have tested positive for allergens like Aspergillus, Yeast, and Candida on food allergy and sensitivity tests, it may be prudent to extend testing to include environmental allergens on a panel such as the Environmental Allergy Test (88 Antigen IgE) By Infinite Allergy Labs.
This approach enables healthcare providers to comprehensively assess the patient's allergic sensitivities, as exposure to environmental allergens can exacerbate existing symptoms or contribute to overall allergic burden. Identifying and addressing environmental allergens alongside food sensitivities can lead to more effective management and treatment strategies tailored to the individual patient's needs, ultimately improving their quality of life.
Research supports the importance of comprehensive allergy testing to guide personalized treatment approaches and minimize allergic reactions. [24.]
Beans, Legumes, Nuts, Seeds
Dairy, Meat, Poultry
Fish, Shellfish
Fruits, Vegetables
Grains
Herbs, Spices, Beverages
Molds, Fungi
Animal
Insect/MIte
Mold/Fungus
Pollen, Crops
Pollen, Grass
Pollen, Tree
Pollen, Weed
IgE, an immunoglobulin subclass, plays a pivotal role in the body's allergic responses, particularly immediate hypersensitivity reactions triggered by exposure to foreign substances. These reactions can manifest as symptoms ranging from mild itching and hives to severe anaphylactic shock, depending on the individual's sensitivity and the allergen involved.
By measuring serum levels of IgE, our test helps identify potential allergic triggers, including food items and environmental antigens like pollen or pet dander, aiding in the diagnosis and management of allergic conditions.
Additionally, IgE-mediated reactions can also manifest with digestive symptoms such as nausea, vomiting, diarrhea, and abdominal pain, highlighting the importance of comprehensive testing for diagnosing allergic conditions involving the gastrointestinal tract. [12.]
Food sensitivity testing using IgG antibodies is employed by Infinite Allergy Labs in their FAST 88 Foods panel due to its potential clinical relevance in identifying delayed immune responses to specific food antigens.
While IgE-mediated food allergies typically provoke immediate hypersensitivity reactions, IgG-mediated responses are associated with delayed onset reactions, making them challenging to diagnose clinically. However, accumulating evidence suggests that IgG antibody testing for food sensitivities may shed light for clinicians. [6., 15., 19.]
Some studies indicate that IgG-mediated immune responses might contribute to the pathogenesis of gastrointestinal inflammation. [16.] By detecting IgG antibodies to specific food antigens, the FAST 88 Foods panel aims to identify potential triggers for immune-mediated reactions and provide insights into personalized dietary modifications to alleviate symptoms and improve overall health outcomes.
IgG4, a subtype of immunoglobulin G antibodies, plays a crucial role in modulating immune responses, particularly in the context of allergies. Research indicates that IgG4 antibodies can help neutralize allergic reactions orchestrated by IgE, thereby mitigating histamine responses and promoting immune tolerance to foods.
However, it's essential to maintain a balanced level of IgG4, as excessive amounts can paradoxically lead to increased inflammation and immune sensitization; increased IgG4 levels have been associated with allergies and with autoimmune conditions. For instance, elevated IgG4 levels have been implicated in conditions such as rheumatoid arthritis, myasthenia gravis, pemphigus vulgaris and thrombotic thrombocytopenic purpura. [8. 11.13.]
C3b/d (Complement Component 3) is a protein of the innate immune system that is activated by microorganisms in the absence of an antibody. The inclusion of complement proteins C3d and C3b in the Food Allergy and Sensitivity Testing (FAST 88 Foods: IgE, IgG4, IgG, C3b/d) by Infinite Allergy Labs provides a more comprehensive assessment of the immune response to dietary antigens.
Complement proteins play a crucial role in the immune cascade triggered by IgG-mediated reactions. Specifically, C3d and C3b are involved in the opsonization of immune complexes, facilitating their recognition and clearance by phagocytic cells; their role can increase the actions of IgG antibodies many times over.
By measuring levels of C3d and C3b alongside IgG antibodies against 88 common foods, this test offers valuable insights into the inflammatory response associated with food sensitivities.
Complement activation, particularly through the C3d/C3b pathway, may contribute to the pathogenesis of various immune-mediated disorders, including food sensitivities and allergic reactions. [26.]
IgE serum testing for allergens offers a comprehensive approach to identify specific allergens triggering allergic reactions in individuals. By testing for both seasonal and perennial allergens, healthcare providers can gain valuable insights into the patient's allergic sensitivities throughout the year.
Seasonal allergens, such as pollen from trees, grasses, and weeds, typically cause allergic symptoms during specific times of the year. In contrast, perennial allergens, including dust mites, pet dander, and mold, can trigger symptoms year-round. Differentiating between seasonal and perennial allergens allows for targeted treatment and management strategies tailored to the patient's specific sensitivities and environmental exposures.
For instance, while seasonal allergies may require seasonal avoidance measures or short-term medication use, perennial allergies necessitate ongoing allergen avoidance strategies and long-term management plans to address chronic health problems caused by perennial allergen exposure.
Testing for both food and environmental allergens enables healthcare providers to comprehensively assess the patient's allergic sensitivities, as exposure to environmental allergens can exacerbate existing symptoms or contribute to overall allergic burden.
Identifying and addressing environmental allergens alongside food sensitivities can lead to more effective management and treatment strategies tailored to the individual patient's needs, ultimately improving their quality of life. [24.]
Testing for IgE-mediated immune responses to molds, such as through the 88 Antigen IgE Environmental Panel, provides valuable clinical information about a patient's immediate hypersensitivity to specific mold allergens. Serum IgE has been correlated with IgE-mediated sensitization and inflammatory markers in response to mold exposure, making serum IgE a reliable marker for immune response to mold exposure. [7.]
This type of testing helps identify individuals who are sensitized to molds and at risk of developing allergic reactions upon exposure. By pinpointing the specific molds triggering allergic responses, healthcare providers can tailor treatment strategies, such as avoidance measures or allergen immunotherapy, to effectively manage symptoms and improve patient outcomes.
In contrast, urine mycotoxin testing aims to detect mycotoxins, toxic substances produced by molds, in the body. [23.] While urine mycotoxin testing may provide insights into mold exposure, it has limitations in assessing allergic sensitization and immediate immune responses. Furthermore, the clinical relevance and interpretation of mycotoxin levels in urine remain debated within the medical community.
Therefore, for evaluating IgE-mediated immune responses to molds and guiding allergy management, testing for mold-specific IgE antibodies is a more established and clinically relevant approach.
Many individuals can benefit from the Food Allergy and Sensitivity Testing (FAST 88 Foods: IgE, IgG4, IgG, C3b/d) offered by Infinite Allergy Labs:
Individuals experiencing chronic digestive issues: many patients experience frustrating digestive issues such as irritable bowel syndrome (IBS), bloating, gas, diarrhea, or constipation yet receive no answers. The Food Allergy and Sensitivity Testing (FAST 88 Foods: IgG with C3d/C3b) By Infinite Allergy Labs may provide insight into food sensitivities that have been linked to gastrointestinal symptoms. [4.]
Those suffering from skin conditions: eczema, psoriasis, or chronic urticaria may be linked to food sensitivities that exacerbate these dermatological conditions. [9.]
People with autoimmune disorders: emerging evidence suggests a potential association between food sensitivities and autoimmune diseases like rheumatoid arthritis, lupus, and Hashimoto's thyroiditis. [4.]
Individuals experiencing unexplained symptoms without relief: fatigue, brain fog, headaches, joint pain, or mood disturbances, as these symptoms are often associated with food sensitivities and immune-mediated reactions. [15.]
People struggling to lose weight: those people who find weight loss challenging despite typical diet and lifestyle interventions may benefit from a food sensitivity assessment. [22.]
Allergy sufferers: Individuals experiencing symptoms such as sneezing, nasal congestion, itching, or wheezing, which may indicate allergic reactions to environmental allergens, can benefit from the Environmental Allergy Test. Identifying specific allergens can guide personalized treatment plans, including avoidance strategies, medication management, or allergen immunotherapy, leading to symptom relief and improved quality of life. [1., 3..]
Patients with chronic respiratory conditions: Individuals with conditions like asthma, allergic rhinitis, or chronic obstructive pulmonary disease (COPD) may benefit from the Environmental Allergy Test to identify triggers exacerbating their symptoms. Avoiding exposure to specific allergens can help reduce respiratory inflammation. [1., 3., 5.]
Individuals with suspected allergic reactions: Patients experiencing unexplained symptoms such as skin rashes, hives, or gastrointestinal distress may benefit from allergen testing to identify potential triggers in their environment. Allergies and sensitivities can manifest in troubling dermatological and/or gastrointestinal symptoms, and identifying and avoiding specific allergens can help alleviate symptoms and prevent future allergic reactions, promoting overall health and well-being. [17.]
Those seeking to improve indoor air quality: Individuals concerned about indoor air quality, particularly in homes or workplaces, can benefit from allergen testing to identify potential sources of allergen exposure, such as dust mites, pet dander, or mold. Taking proactive measures to reduce allergen levels can help create a healthier indoor environment and reduce the risk of allergic symptoms. [20.]
People suffering from unexplained symptoms including fatigue, brain fog, pain, infertility:
Individuals experiencing unexplained fatigue, brain fog, pain, infertility, and other systemic symptoms may benefit from the Environmental Allergy Test by Infinite Allergy Labs to uncover potential underlying allergens contributing to their health issues.
Allergic reactions to environmental allergens can manifest in various ways, including systemic inflammation, immune dysregulation, and oxidative stress, which may exacerbate symptoms such as fatigue and cognitive dysfunction. Identifying and addressing specific allergens through avoidance strategies or immunotherapy can help alleviate symptoms and improve overall health and well-being.
Additionally, allergic reactions have been associated with chronic pain conditions and infertility, highlighting the importance of addressing environmental triggers in comprehensive treatment approaches. [21., 25.]
This test may also benefit those seeking to optimize their diet and overall health by identifying potential triggers for immune-mediated responses and making informed dietary modifications accordingly.
It is important to note that every result should be interpreted within the context of the individual’s health history.
[1.] Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet JJ, Cardona V, Chiang WC, Demoly PM, DuBuske LM, Ferrer Puga M, Gerth van Wijk R, González Díaz SN, Gonzalez-Estrada A, Jares E, Kalpaklioğlu AF, Kase Tanno L, Kowalski ML, Ledford DK, Monge Ortega OP, Morais Almeida M, Pfaar O, Poulsen LK, Pawankar R, Renz HE, Romano AG, Rosário Filho NA, Rosenwasser L, Sánchez Borges MA, Scala E, Senna GE, Sisul JC, Tang MLK, Thong BY, Valenta R, Wood RA, Zuberbier T. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb 25;13(2):100080. doi: 10.1016/j.waojou.2019.100080. Erratum in: World Allergy Organ J. 2021 Jun 17;14(7):100557. PMID: 32128023; PMCID: PMC7044795.
[2.] Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004 Oct;53(10):1459-64. doi: 10.1136/gut.2003.037697. PMID: 15361495; PMCID: PMC1774223.
[3.] Birch K, Pearson-Shaver AL. Allergy Testing. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537020/
[4.] Coucke F. Food intolerance in patients with manifest autoimmunity. Observational study. Autoimmun Rev. 2018 Nov;17(11):1078-1080. doi: 10.1016/j.autrev.2018.05.011. Epub 2018 Sep 11. PMID: 30213697.
[5.] Froidure A, Mouthuy J, Durham SR, Chanez P, Sibille Y, Pilette C. Asthma phenotypes and IgE responses. European Respiratory Journal. 2015;47(1):304-319. doi:https://doi.org/10.1183/13993003.01824-2014
[6.] Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79. doi: 10.1007/s11916-019-0819-4. PMID: 31456119.
[7.] Kespohl S, Liebers V, Maryska S, Meurer U, Litzenberger C, Merget R, Raulf M. What should be tested in patients with suspected mold exposure? Usefulness of serological markers for the diagnosis. Allergol Select. 2022 Mar 29;6:118-132. doi: 10.5414/ALX02298E. PMID: 35392215; PMCID: PMC8982061.
[8.] Koneczny I. Update on IgG4-mediated autoimmune diseases: New insights and new family members. Autoimmunity Reviews. 2020;19(10):102646. doi:https://doi.org/10.1016/j.autrev.2020.102646
[9.] Laura, Jong, Constance, et al. IgG Antibodies in Food Allergy Influence Allergen–Antibody Complex Formation and Binding to B Cells: A Role for Complement Receptors. Journal of Immunology. 2013;191(7):3526-3533. doi:https://doi.org/10.4049/jimmunol.1202398
[10.] Liu Y, Yan H, Shao F, Li QH, Cui M. Correlation between childhood eczema and specific IgG antibody level. J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):341-344. PMID: 29685016.
[11.] Maslinska M, Dmowska-Chalaba J, Jakubaszek M. The Role of IgG4 in Autoimmunity and Rheumatic Diseases. Front Immunol. 2022 Jan 25;12:787422. doi: 10.3389/fimmu.2021.787422. PMID: 35145508; PMCID: PMC8821096.
[12.] Pearson JS, Niven RM, Meng J, Atarodi S, Whorwell PJ. Immunoglobulin E in irritable bowel syndrome: another target for treatment? A case report and literature review. Therap Adv Gastroenterol. 2015 Sep;8(5):270-7. doi: 10.1177/1756283X15588875. PMID: 26327917; PMCID: PMC4530434.
[13.] Qin L, Tang LF, Cheng L, Wang HY. The clinical significance of allergen-specific IgG4 in allergic diseases. Front Immunol. 2022 Oct 25;13:1032909. doi: 10.3389/fimmu.2022.1032909. PMID: 36389804; PMCID: PMC9648126.
[14.] Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997 May 8;336(19):1356-63. doi: 10.1056/NEJM199705083361904. PMID: 9134876.
[15.] Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016 Nov-Dec;36(6):386-390. doi: 10.5144/0256-4947.2016.386. PMID: 27920409; PMCID: PMC6074204.
[16.] Simeonova D, Ivanovska M, Murdjeva M, Carvalho AF, Maes M. Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays. Curr Top Med Chem. 2018;18(19):1641-1655. doi: 10.2174/1568026618666181115100610. PMID: 30430944.
[17.] van Splunter M, Liu L, van Neerven RJJ, Wichers HJ, Hettinga KA, de Jong NW. Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy. Nutrients. 2020 Dec 15;12(12):3830. doi: 10.3390/nu12123830. PMID: 33333859; PMCID: PMC7765270.
[18.] Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clin Exp Immunol. 2008 Sep;153 Suppl 1(Suppl 1):3-6. doi: 10.1111/j.1365-2249.2008.03713.x. PMID: 18721321; PMCID: PMC2515351.
[19.] Vita AA, Zwickey H, Bradley R. Associations between food-specific IgG antibodies and intestinal permeability biomarkers. Front Nutr. 2022 Sep 6;9:962093. doi: 10.3389/fnut.2022.962093. PMID: 36147305; PMCID: PMC9485556.
[20.] Wang H, Li XB, Chu XJ, Cao NW, Wu H, Huang RG, Li BZ, Ye DQ. Ambient air pollutants increase the risk of immunoglobulin E-mediated allergic diseases: a systematic review and meta-analysis. Environ Sci Pollut Res Int. 2022 Jul;29(33):49534-49552. doi: 10.1007/s11356-022-20447-z. Epub 2022 May 20. PMID: 35595897; PMCID: PMC9122555.
[21.] Wasilewska E, Małgorzewicz S. Impact of allergic diseases on fertility. Postepy Dermatol Alergol. 2019 Oct;36(5):507-512. doi: 10.5114/ada.2019.89501. Epub 2019 Nov 12. PMID: 31839765; PMCID: PMC6906954.
[22.] Wilders-Truschnig M, Mangge H, Lieners C, Gruber H, Mayer C, März W. IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles. Exp Clin Endocrinol Diabetes. 2008 Apr;116(4):241-5. doi: 10.1055/s-2007-993165. Epub 2007 Dec 10. PMID: 18072008.
[23.] World Health Organization. Mycotoxins. Who.int. Published May 9, 2018. https://www.who.int/news-room/fact-sheets/detail/mycotoxins
[24.] Xing H, Wang J, Sun Y, Wang H. Recent Advances in the Allergic Cross-Reactivity between Fungi and Foods. J Immunol Res. 2022 Oct 7;2022:7583400. doi: 10.1155/2022/7583400. PMID: 36249419; PMCID: PMC9568318.
[25.] Yang TY, Kuo HT, Chen HJ, Chen CS, Lin WM, Tsai SY, Kuo CN, Kao CH. Increased Risk of Chronic Fatigue Syndrome Following Atopy: A Population-Based Study. Medicine (Baltimore). 2015 Jul;94(29):e1211. doi: 10.1097/MD.0000000000001211. PMID: 26200644; PMCID: PMC4603016.
[26.] Yves Laumonnier, Rabia Ülkü Korkmaz, Nowacka AA, Jörg Köhl. Complement‐mediated immune mechanisms in allergy. European Journal of Immunology. 2023;53(10). doi:https://doi.org/10.1002/eji.202249979
This bundle combines the 88 Food Allergy and Sensitivity Test (FAST) and the 88 Antigen IgE Environmental Allergy Test. It measures four distinct immune reactions (IgE, IgG, IgG4, and complement C3b/d) to 88 common food antigens and IgE reactions to 88 common environmental allergens.
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